Experimental Models List
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Experimental Models List
| Model ID | Category | Classification | Type | Model | Description | Source | References | Details |
|---|---|---|---|---|---|---|---|---|
| M009 | Ex vivo | Tissue culture system | Ussing chamber | Ussing chamber | Two-compartment system with electrodes, measures ion transport, intestinal permeability, host-micro… | Human, Animal | 37519330 | Details |
| M008 | In vitro | Immunological co-culture | RAW 246.7 co-culture | RAW 246.7 | Mouse tumor-derived cell line (Abelson leukemia virus), mimics murine bone marrow-derived macrophag… | Mouse | 37519330 | Details |
| M007 | In vitro | Immunological co-culture | THP-1 co-culture | THP-1 | Human leukemia cell line derived from acute monocytic leukemia patient, similar to primary monocyte… | Human | 37519330 | Details |
| M006 | In vitro | Immunological co-culture | PBMC co-culture | PBMC | Isolated from peripheral blood or buffy coats of healthy donors, composed of dendritic cells, lymph… | Human | 37519330 | Details |
| M005 | In vitro | Cell line | Tumor-derived cell line | T84 | Human colon cancer-derived cell line, has microvilli, can develop into crypt-like cells when stimul… | Human | 37519330 | Details |
| M004 | In vitro | Co-culture cell model | Caco-2/HT29-MTX co-culture | Caco-2/HT29-MTX | Co-culture of Caco-2 (absorptive cells) and HT29-MTX (mucus-secreting goblet cells), ratios 90:10 o… | Human | 37519330 | Details |
| M003 | In vitro | Organoid | Intestinal organoid | Organoids | 3D structures derived from pluripotent or adult tissue stem cells (e.g., Lgr5+ ASCs), can different… | Human, Rodent | 37519330 | Details |
| M002 | In vitro | Cell line | Tumor-derived cell line | HT29 | Human colon cancer-derived cell line, can differentiate into enterocytes or mucus-generating cells,… | Human | 37519330 | Details |
| M029 | In vivo | Bacterial induced model | Adherent-invasive E. coli (AIEC)-induced colitis model | AIEC-induced colitis | Infection with AIEC (requires low-dose DSS pretreatment), induces UC-like colitis, clinical feature… | Rodents | 24906689 | Details |
| M038 | In vivo | Genetically engineered model (conventional knock-out) | Gαi2-/- mice model | Gαi2-/- mice colitis | Gαi2 gene knock-out, spontaneous severe colitis by 8–12 weeks of age, resembles UC, clinical featur… | Mice | 24906689 | Details |