Experimental Models List
Source Distribution
Model Class Distribution
Filter Conditions
Experimental Models List
| Model ID | Category | Classification | Type | Model | Description | Source | References | Details |
|---|---|---|---|---|---|---|---|---|
| M037 | In vivo | Genetically engineered model (conventional knock-out) | MDR1A-/- mice model | MDR1A-/- mice colitis | MDR1A gene knock-out, spontaneous severe colitis by TH1 type inflammation, resembles UC, clinical f… | Mice | 24906689 | Details |
| M036 | In vivo | Genetically engineered model (conventional knock-out) | A20-/- mice model | A20-/- mice colitis | A20 gene knock-out, spontaneous colitis, cachexia, premature death, clinical features include intes… | Mice | 24906689 | Details |
| M035 | In vivo | Genetically engineered model (conventional knock-out) | NOD2-/- mice model | NOD2-/- mice colitis | NOD2 gene knock-out, exhibits CD-like features, clinical features include intestinal inflammation, … | Mice | 24906689 | Details |
| M034 | In vivo | Genetically engineered model (conventional knock-out) | IL-2-/- mice model | IL-2-/- mice colitis | IL-2 gene knock-out, chronic colonic mucosa/submucosa inflammation by 8–9 weeks of age, resembles U… | Mice | 24906689 | Details |
| M033 | In vivo | Genetically engineered model (conventional knock-out) | TGF-β-/- mice model | TGF-β-/- mice colitis | TGF-β gene knock-out, multi-organ dysfunction including severe colitis, dies within 4–5 weeks, clin… | Mice | 24906689 | Details |
| M032 | In vivo | Genetically engineered model (conventional knock-out) | IL-10-/- mice model | IL-10-/- mice colitis | IL-10 gene knock-out, spontaneous transmural pancolitis and cecal inflammation by 2–4 months of age… | Mice | 24906689 | Details |
| M031 | In vivo | Spontaneous model | SAMP1/Yit mice model | SAMP1/Yit mice ileitis/colitis | Spontaneous severe inflammation in terminal ileum (resembling CD), develops at 10 weeks of age, his… | Mice | 24906689 | Details |
| M030 | In vivo | Spontaneous model | C3H/HejBir mice model | C3H/HejBir mice colitis | Spontaneous chronic focal inflammation localized to right colon and cecum, develops at 3–4 weeks of… | Mice | 24906689 | Details |
| M001 | In vitro | Cell line | Tumor-derived cell line | Caco-2 | Immortalized human colorectal adenocarcinoma cells, differentiate into intestinal epithelial cells … | Human | 37519330 | Details |
| M028 | In vivo | Bacterial induced model | Salmonella-induced colitis model | Salmonella-induced colitis | Oral infection with Salmonella typhimurium/Salmonella dublin, induces acute colitis resembling UC, … | Rodents | 24906689 | Details |