| Drug ID: | Drug10 |
|---|---|
| Drug Name: | Azathioprine |
| CID: | 2265 |
| DrugBank ID: | DB00993 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT03370601, , NCT02413047, , NCT06213857, , NCT02281799, , NCT03101800, , NCT04882683, , NCT03151525, , NCT00984568, , NCT02579733, , NCT01817972 |
| Molecular Formula: | C9H7N7O2S |
| Molecular Weight: | 277.27 g/mol |
| Isomeric SMILES: | CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-] |
| Synonyms: | azathioprine; 446-86-6; Azothioprine; Azathioprin; Azamun; Azanin; Azatioprin; Azasan; Ccucol; Imurek |
| Phase 0: | 3 |
| Phase 1: | 7 |
| Phase 2: | 38 |
| Phase 3: | 59 |
| Phase 4: | 44 |
| Description: | An immunosuppressive antimetabolite pro-drug. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis. |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt80 | 2265 | Azathioprine | 5243 | ABCB1 | Homo sapiens (human) | 17262810 | ABCB1 gene polymorphism affects the susceptibility to azathioprine |
| dt81 | 2265 | Azathioprine | 8647 | ABCB11 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in decreased expression of ABCB11 mRNA |
| dt82 | 2265 | Azathioprine | 5244 | ABCB4 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in increased expression of ABCB4 mRNA |
| dt83 | 2265 | Azathioprine | 1244 | ABCC2 | Homo sapiens (human) | 22623647 | Azathioprine results in increased expression of ABCC2 mRNA |
| dt84 | 2265 | Azathioprine | 1244 | ABCC2 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in increased expression of ABCC2 mRNA |
| dt85 | 2265 | Azathioprine | 8714 | ABCC3 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in increased expression of ABCC3 mRNA |
| dt86 | 2265 | Azathioprine | 10257 | ABCC4 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in increased expression of ABCC4 mRNA |
| dt87 | 2265 | Azathioprine | 9429 | ABCG2 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in decreased expression of ABCG2 mRNA |
| dt88 | 2265 | Azathioprine | 64240 | ABCG5 | Rattus norvegicus (Norway rat) | 27765674 | Azathioprine results in decreased expression of ABCG5 mRNA |
| dt89 | 2265 | Azathioprine | 63874 | ABHD4 | Homo sapiens (human) | 22623647 | Azathioprine results in increased expression of ABHD4 mRNA |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT05584228 | Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease | NA | NOT_YET_RECRUITING | Nantes University Hospital | Crohn Disease | DRUG: Azathioprine + infliximab|PROCEDURE: Intest… | Details |
| NCT05456776 | Azathioprine Linked With Impaired Intestinal Epithelial Postoperative Regeneration in Crohn's Disease | NULL | COMPLETED | Centre of Postgraduate Medical Education | Inflammatory Bowel Diseases | None | Details |
| NCT05321485 | The Effect of MedicijnWijs on Adherence to Azathioprine Therapy in Adolescents With IBD | NA | UNKNOWN | Maxima Medical Center | Inflammatory Bowel Diseases|Crohn Disease|Ulcerat… | OTHER: MedicijnWijs | Details |
| NCT07138898 | Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty | PHASE2 | NOT_YET_RECRUITING | NYU Langone Health | Rheumatic Disease | DRUG: Methotrexate|DRUG: Sulfasalazine|DRUG: Hydr… | Details |
| NCT05040464 | Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled Trial | PHASE3 | RECRUITING | Centre Hospitalier Universitaire, Amiens | Crohn Disease|Azathioprine|Methotrexate | DRUG: AZA capsules|DRUG: MTX|BIOLOGICAL: blood sa… | Details |
| NCT04882683 | Clinical Study of Cord Blood Mononuclear Cells on Treatment of Hormone-resistant or Hormone-dependent Ulcerative Colitis | NA | UNKNOWN | Shandong Qilu Stem Cells Engineering Co., Ltd. | Ulcerative Colitis | DRUG: Prednisone|DRUG: Azathioprine|DRUG: Adalimu… | Details |
| NCT04761952 | N-3 Polyunsaturated Fatty Acids Prevent Postoperative Recurrence of Crohn's Disease | NA | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Inflammatory Bowel Diseases|Crohn Disease|Polyuns… | DRUG: azathioprine|DRUG: infliximab|DRUG: N-3 Pol… | Details |
| NCT04160325 | Effect of the Exclusive Enteral Nutrition Combined With Azathioprine for Remission of Crohn's Diseases After Surgery | NA | UNKNOWN | Zhu Weiming | Crohn Disease | DIETARY_SUPPLEMENT: postoperative 3-month exclusi… | Details |
| NCT03681652 | Post-Operative Crohn's Disease Outcome in Children | NULL | RECRUITING | Schneider Children's Medical Center, Israel | Crohn Disease | DRUG: Azathioprine|DRUG: Anti-TNF Drug | Details |
| NCT03580876 | Addition of Azathioprine in IBD Patients With Immunogenic Failure | PHASE4 | UNKNOWN | Védrines, Philippe, M.D. | Clinical Failure After Switch | DRUG: addition of azathioprine|DRUG: Switch to a … | Details |
| NCT03393247 | The Therapy Effect of Azathioprine Initial or 14 Weeks After Combined With Infliximab on CD | NA | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Crohn Disease | DRUG: infliximab and azathioprine combination at … | Details |
| NCT03370601 | Evaluation of the Clinical and Immunological Impact of Two Therapeutic Strategies in Chronic Inflammatory Diseases | NA | TERMINATED | University Hospital, Lille | Inflammatory Bowel Diseases | DRUG: Infliximab|DRUG: Mercaptopurine|DRUG: Azath… | Details |
| NCT03185611 | Effectiveness of Rifaximin Combined With Thiopurine on Preventing Postoperative Recurrence in Crohn's Disease | PHASE3 | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Crohn Disease | DRUG: Rifaximin|DRUG: Azathioprine | Details |
| NCT03151525 | Two Therapeutic Strategies for the Maintenance of Remission in Patients With Ulcerative Colitis | PHASE4 | UNKNOWN | Istituto Clinico Humanitas | Colitis, Ulcerative | DRUG: Azathioprine|DRUG: Infliximab | Details |
| NCT03101800 | Beneficial and Harmful Effects of Azathioprine and Allopurinol Versus Standard Azathioprine Therapy for Patients With Ulcerative Colitis | PHASE3 | UNKNOWN | Hvidovre University Hospital | Colitis, Ulcerative|Colitis Ulcerative Exacerbati… | DRUG: Azathioprine and Allopurinol|DRUG: Azathiop… | Details |
| NCT02998827 | Thalidomide Results in Diminished Ovarian Reserve in Reproductive Age Female IBD Patients | NA | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Crohn Disease | DRUG: Thalidomide|DRUG: infliximab, azathioprine|… | Details |
| NCT02929706 | Pre-genotype NUDT 15 R139C on Reducing Thiopurine-induced Leucopenia in Inflammatory Bowel Disease | NA | UNKNOWN | Sixth Affiliated Hospital, Sun Yat-sen University | Thiopurine-induced Leukopenia | GENETIC: Pre-genotype NUDT15 and optimize azathio… | Details |
| NCT02852694 | Reduce Risk for Crohn's Disease Patients | PHASE4 | COMPLETED | PIBD-Net | Crohn's Disease | DRUG: Methotrexate|DRUG: Adalimumab|DRUG: Azathio… | Details |
| NCT02579733 | Azathioprine Based on Endoscopy After Clinical Remission in Moderate to Severe Ulcerative Colitis | PHASE4 | TERMINATED | Kyungpook National University Hospital | Ulcerative Colitis | DRUG: Azathioprine|DRUG: Placebo | Details |
| NCT02517684 | Top-down Infliximab Study in Kids With Crohn's Disease | PHASE4 | COMPLETED | Erasmus Medical Center | Crohn's Disease | DRUG: Infliximab|DRUG: Prednisolone|OTHER: Exclus… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| S02 | Immunosuppression | Classic immunosuppressive drugs | azathioprine; 6-mercaptopurine; methotrexate; ciclosporin-A; tacrolimus | Ciclosporin-A and tacrolimus bind to specific intracellular… | Details |
Treatment with infliximab or azathioprine negatively impact the efficacy of hep…
PMID: 25967740
Year: 2015
Relationship Type:
Treatment
Score: 6.3
OBJECTIVE: To assess the effectiveness of solution-focused therapy (SFT) on fatigue and quality of life (QoL) in patients with fatigued inflammatory…
Relationship between azathioprine dosage, 6-thioguanine nucleotide levels, and …
PMID: 25851563
Year: 2015
Relationship Type:
Treatment
Score: 6.3
Comment in Gastrointest Endosc. 2014 Nov;80(5):849-51. BACKGROUND: Colonoscopic surveillance for neoplasia is recommended for patients with inf…
Concomitant use of azathioprine/6-mercaptopurine decreases the risk of anti-TNF…
PMID: 25789922
Year: 2015
Relationship Type:
Treatment
Score: 6.3
BACKGROUND: Chronic periodontitis (CP) is an inflammatory condition affecting tooth-supporting tissues and alveolar bone that surround the tooth, le…
Dexamethasone and azathioprine promote cytoskeletal changes and affect mesenchy…
PMID: 25756665
Year: 2015
Relationship Type:
Association
Score: 6.3
Infectious bursal disease (IBD) is an acute, infectious, immunosuppressive disease affecting young chicken worldwide. The etiological agent IBD viru…
Differences in the adverse effects of azathioprine between inflammatory bowel d…
PMID: 25530586
Year: 2014
Relationship Type:
Adverse Effect
Score: 6.3
OBJECTIVES: Questionnaires exist to assess inflammatory bowel disease (IBD)-related knowledge of adults. Owing to wording and content concerns, thes…
Update 2014: advances to optimize 6-mercaptopurine and azathioprine to reduce t…
PMID: 25248004
Year: 2015
Relationship Type:
Adverse Effect
Score: 6.3
Not found
Azathioprine induced Epstein Barr virus-positive mucocutaneous ulcer arising in…
PMID: 25213810
Year: 2014
Relationship Type:
Association
Score: 6.3
[6-mercaptopurine as a safe therapeutic alternative for patients with inflammat…
PMID: 25198089
Year: 2014
Relationship Type:
Treatment
Score: 6.3
Long-term prevention of postoperative Crohn's disease recurrence with azathiopr…
PMID: 25139367
Year: 2015
Relationship Type:
Treatment
Score: 6.3
INTRODUCTION: Due to their immunomodulatory properties, mesenchymal stromal cells (MSCs) have been used for auto-immune disease treatment. Crohn dis…
Safe azathioprine treatment in a pediatric ulcerative colitis patient with TPMT…
PMID: 25036765
Year: 2014
Relationship Type:
Treatment
Score: 6.3
Long-term combination therapy with infliximab plus azathioprine predicts sustai…
PMID: 24983979
Year: 2014
Relationship Type:
Treatment
Score: 6.3
BACKGROUND: The results of previous studies on the effectiveness of antibiotics in ulcerative colitis (UC) seem more effective when used orally. In …
Use of azathioprine in IBD: modern aspects of an old drug
PMID: 24943205
Year: 2014
Relationship Type:
Association
Score: 6.3
BACKGROUND AND AIMS: The etiopathogenesis of inflammatory bowel diseases (IBD) remains largely unexplained. Flotillins (flotillin-1 and flotillin-2)…
Risk of lymphoma in patients with inflammatory bowel disease treated with azath…
PMID: 24879926
Year: 2015
Relationship Type:
Association
Score: 6.3
OBJECTIVES: Antibodies to infliximab (ATIs) have been associated with loss of clinical response and lower serum infliximab (IFX) levels in some stud…
New genetic biomarkers predicting azathioprine blood concentrations in combinat…
PMID: 24762746
Year: 2014
Relationship Type:
Treatment
Score: 6.3
BACKGROUND: Obesity has been associated with a more severe disease course in inflammatory bowel disease (IBD) and epidemiological data identified di…
Awareness of adverse effects of azathioprine in patients with inflammatory bowe…
PMID: 24757277
Year: 2014
Relationship Type:
Adverse Effect
Score: 6.3
Pharmacogenetics of azathioprine in inflammatory bowel disease: a role for glut…
PMID: 24707136
Year: 2014
Relationship Type:
Association
Score: 6.3
Not found
Early use of azathioprine in Crohn's disease
PMID: 24468182
Year: 2014
Relationship Type:
Association
Score: 6.3
Shrinking indications for azathioprine in Crohn's disease: a conclusion too pre…
PMID: 24468178
Year: 2014
Relationship Type:
Association
Score: 6.3
Azathioprine in early Crohn's disease: time to revisit patient selection and en…
PMID: 24468167
Year: 2014
Relationship Type:
Clinical Trial
Score: 6.3
Comment on Aliment Pharmacol Ther. 2013 Jan;37(2):225-33.
6-Mercaptopurine/Azathioprine remains an important contributor in managing Croh…
PMID: 24462321
Year: 2014
Relationship Type:
Treatment
Score: 6.3
Two large studies concluded that AZA started early after diagnosis of Crohn's disease have no late maintenance value. This is contrary to previous st…