| Drug ID: | Drug181 |
|---|---|
| Drug Name: | Steroids |
| CID: | 139082353 |
| DrugBank ID: | NULL |
| Modality: | Small Molecule |
| Groups: | NULL |
| US Approved: | NULL |
| Other Approved: | NULL |
| Identifier: | NCT05702879, , NCT03460847 |
| Molecular Formula: | C26H44N2O |
| Molecular Weight: | 400.6 g/mol |
| Isomeric SMILES: | C[C@H]([C@@H]1CC[C@H]2[C@]1(CC[C@@H]3[C@@H]2CC=C4[C@]3(CC[C@@H](C4)N(C)C)C)C)N(C)C(=O)C |
| Synonyms: | Steroid; 3alpha-Dimethylamino-20-(N-methylacetamido)pregn-5-ene; Steroids; Steroid Compound; Arnolds, Gear, Gym Candy, Juice, Pumpers, Roids, Stackers, Weight Gainers |
| Phase 0: | 0 |
| Phase 1: | 0 |
| Phase 2: | 0 |
| Phase 3: | 0 |
| Phase 4: | 0 |
| Description: | NULL |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt1299 | 139082353 | Steroids | 1576 | CYP3A4 | Homo sapiens (human) | 15955870 | Steroids results in increased expression of CYP3A4 |
| dt1300 | 139082353 | Steroids | 2554 | GABRA1 | Rattus norvegicus (Norway rat) | 18275132 | GABRA1 protein mutant form results in decreased susceptibility to steroids analog|steroids analog promotes the reaction [gamma-aminobutyric acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] |
| dt1301 | 139082353 | Steroids | 2561 | GABRB2 | Rattus norvegicus (Norway rat) | 18275132 | Steroids analog promotes the reaction [gamma-aminobutyric acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] |
| dt1302 | 139082353 | Steroids | 2566 | GABRG2 | Rattus norvegicus (Norway rat) | 18275132 | Steroids analog promotes the reaction [gamma-aminobutyric acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] |
| dt1303 | 139082353 | Steroids | 3565 | IL4 | Rattus norvegicus (Norway rat) | 10685002 | Steroids results in decreased expression of IL4 protein |
| dt1304 | 139082353 | Steroids | 5069 | PAPPA | Mus musculus (house mouse) | 20130263 | PAPPA protein affects the chemical synthesis of steroids |
| dt1305 | 139082353 | Steroids | 5443 | POMC | Rattus norvegicus (Norway rat) | 20021565 | POMC protein affects the reaction [ethanol results in increased abundance of steroids] |
| dt1306 | 139082353 | Steroids | 5443 | POMC | Rattus norvegicus (Norway rat) | 1668613 | POMC protein alternative form affects the abundance of steroids |
| dt1307 | 139082353 | Steroids | 103142 | Rdh9 | Mus musculus (house mouse) | 17270348 | RDH9 protein results in increased metabolism of steroids |
| dt1308 | 139082353 | Steroids | 6770 | STAR | Rattus norvegicus (Norway rat) | 12699903 | [manganese chloride results in decreased expression of STAR protein] which results in decreased chemical synthesis of steroids |
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT05702879 | Combined Microbiota and Metabolic Signature in Ulcerative Colitis Predicts Anti-Inflammatory Therapy Success | NULL | UNKNOWN | Insel Gruppe AG, University Hospital Bern | Ulcerative Colitis | DRUG: Ozanimod|DRUG: TNF Inhibitor|DRUG: Steroids… | Details |
| NCT05284136 | Exclusion Diet vs corticosteroIds in patientS With activE Crohn's Disease | PHASE2|PHASE3 | UNKNOWN | Assistance Publique - Hôpitaux de Paris | Crohn Disease | DIETARY_SUPPLEMENT: Crohn's disease exclusion die… | Details |
| NCT04999228 | Top Down Versus Step up in Pediatric Ulcerative Colitis | PHASE4 | RECRUITING | Children's Hospital of Fudan University | Ulcerative Colitis|Infliximab|Children | DRUG: Infliximab|DRUG: Corticosteroids | Details |
| NCT04564638 | Long-term Outcome of Patients With Acute Ulcerative Colitis After First Course of Intravenous Corticosteroids | NULL | COMPLETED | Tampere University Hospital | Ulcerative Colitis | DRUG: Corticosteroid | Details |
| NCT03942861 | Sonographic Assessment in Severe Ulcerative Colitis Patients Admitted for Intravenous Corticosteroids and Eligible for Infliximab Rescue Therapy; a Prospective Clinician-blinded Observational Study Protocol. | NULL | UNKNOWN | Copenhagen University Hospital at Herlev | Ulcerative Colitis|Ultrasound Therapy; Complicati… | DRUG: Solu-Medrol | Details |
| NCT03833596 | Exclusive Enteral Nutrition and Corticosteroids Therapy in Crohn's Disease (EENCD) | PHASE4 | TERMINATED | McMaster University | Crohn's Disease | DRUG: Prednisone|DIETARY_SUPPLEMENT: Exclusive En… | Details |
| NCT03460847 | Fecal Microbiota Alterations in Steroid Refractory Active Colitis Ulcerosa | NULL | COMPLETED | Medical University of Graz | Colitis, Ulcerative | DRUG: Steroids | Details |
| NCT02922374 | Ulcerative Colitis Endoscopic Index of Severity and Fecal Calprotectin to Predict the Reaction to Corticosteroids of Acute Severe Ulcerative Colitis | PHASE1|PHASE2 | UNKNOWN | Jinling Hospital, China | Acute Severe Colitis (ASC) | DRUG: corticosteroids | Details |
| NCT02665845 | Combination Corticosteroids+5-aminosalicylic Acids Compared to Corticosteroids Alone (for Ulcerative Colitis). | PHASE3 | COMPLETED | Centre Hospitalier Universitaire de Saint Etienne | Ulcerative Colitis | DRUG: 5-ASA|DRUG: Corticosteroids | Details |
| NCT02619552 | Impact of Medical Treatment on Sexual Function in Patients With Crohn's Disease | NULL | COMPLETED | University of Maryland, Baltimore | Crohn's Disease|IBD | DRUG: Anti-TNF|DRUG: Anti-TNF|DRUG: Steroids | Details |
| NCT02425852 | A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis | PHASE4 | COMPLETED | Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives | Ulcerative Colitis | DRUG: Azathioprine|DRUG: Infliximab|DRUG: Prednis… | Details |
| NCT02324699 | Corticosteroids With Vedolizumab in Crohn's Disease | PHASE4 | TERMINATED | Icahn School of Medicine at Mount Sinai | Crohn's Disease | DRUG: Prednisone|DRUG: Placebo|DRUG: Vedolizumab | Details |
| NCT02033408 | Manipulating the Microbiome in IBD by Antibiotics and FMT | NA | COMPLETED | Shaare Zedek Medical Center | Exacerbation of Ulcerative Colitis|Ulcerative Col… | DRUG: AB (antibiotics)|DRUG: CS (corticosteroids)… | Details |
| NCT01941589 | Corticosteroids+5-aminosalicylic Acid Compared to Corticosteroids in the Treatment of Moderate-severe Ulcerative Colitis | PHASE4 | COMPLETED | Sheba Medical Center | Ulcerative Colitis | DRUG: oral 5-ASA+/-topical 5-ASA+IV corticosteroi… | Details |
| NCT01536535 | Predicting Response to Standardized Pediatric Colitis Therapy | PHASE4 | COMPLETED | Connecticut Children's Medical Center | Ulcerative Colitis | DRUG: Mesalazine|DRUG: IV Corticosteroid|DRUG: Or… | Details |
| NCT00702611 | Efficacy Study of Granulocytapheresis Plus Steroids vs Steroids Alone in Active Steroid Dependant Ulcerative Colitis | PHASE4 | TERMINATED | Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa | Ulcerative Colitis | DEVICE: Granulocyte Monocyte Apheresis (GMA-Apher… | Details |
| NCT00672763 | Adjuvant Vitamin D With Corticosteroids in Active Crohn's Disease | PHASE4 | WITHDRAWN | Imperial College London | Crohn's Disease | DRUG: Colecalciferol D3 (Vigantol Oil)|DRUG: Medi… | Details |
| NCT00514982 | Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome | PHASE2 | WITHDRAWN | National Institute of Allergy and Infectious Diseases (NIAID) | Hermanski-Pudlak Syndrome|Colitis|Cytokines|Lymph… | DRUG: Mesalamine|DRUG: Infliximab|DRUG: Corticost… | Details |
| NCT00269438 | New Tablet Formulation and Dosing Regimen of Balsalazide Disodium in Mildly to Moderately Active Ulcerative Colitis | PHASE3 | COMPLETED | Bausch Health Americas, Inc. | Ulcerative Colitis | DRUG: 5 ASA, enemas, suppositories, corticosteroi… | Details |
| NCT00265772 | Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis | PHASE4 | UNKNOWN | Hôpital Necker-Enfants Malades | Crohn's Disease|Pediatric | DRUG: MODULEN IBD (R) (specific Enteral Nutrition… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| S01 | Anti-inflammatory | inflammatory | 5-Aminosalicylates (5-ASAs); corticosteroids | Crohn's disease and ulcerative colitis are the two main com… | Details |
Letter: previous exposure to corticosteroids increases the risk of post-dischar…
PMID: 31456301
Year: 2019
Relationship Type:
Association
Score: 8.5
Letter: previous exposure to corticosteroids increases the risk of post-dischar…
PMID: 31456298
Year: 2019
Relationship Type:
Association
Score: 8.5
Premedication with intravenous steroids does not influence the incidence of inf…
PMID: 31332475
Year: 2019
Relationship Type:
Treatment
Score: 8.5
When first described in 1976, primary bile acid diarrhea (BAD Type 1) was regarded as a very rare cause of chronic diarrhea. Today, the incidence is…
Nonenzymatic Serum Antioxidant Capacity in IBD and Its Association with the Sev…
PMID: 30986917
Year: 2019
Relationship Type:
Treatment
Score: 8.5
Inflammatory bowel disease (IBD) is associated with a number of extraintestinal complications, including skin lesions. Most reports have shown that …
Successful treatment of pyostomatitis vegetans with ulcerative colitis using da…
PMID: 30969436
Year: 2019
Relationship Type:
Treatment
Score: 8.5
Steroids and Postoperative Complications in IBD
PMID: 30894107
Year: 2019
Relationship Type:
Association
Score: 8.5
Not found
Incidence and predictors of new persistent opioid use following inflammatory bo…
PMID: 30430615
Year: 2019
Relationship Type:
Association
Score: 8.5
Comment in Nat Rev Gastroenterol Hepatol. 2017 Nov;14(11):629. A major challenge in inflammatory bowel disease (IBD) is the integration of dive…
Colon Surgery Risk With Corticosteroids Versus Immunomodulators or Biologics in…
PMID: 30260451
Year: 2019
Relationship Type:
Association
Score: 8.5
Patients with inflammatory bowel disease (IBD) may develop rheumatic diseases, particularly enterophatic spondyloarthritis (ESpA). Similarly, an IBD…
Using corticosteroids appropriately in inflammatory bowel disease: a guide for …
PMID: 30262630
Year: 2018
Relationship Type:
Association
Score: 8.3
Past Time for Doctors to Lessen their Dependence on Corticosteroids in the Trea…
PMID: 29535444
Year: 2018
Relationship Type:
Treatment
Score: 8.3
BACKGROUND: Intestinal inflammation and epithelial injury are the leading actors of inflammatory bowel disease (IBD), causing an excessive pro-infla…
Eruptive Sebaceous Hyperplasia: A Rare Consequence of Systemic Corticosteroids
PMID: 29320598
Year: 2018
Relationship Type:
Adverse Effect
Score: 8.3
BACKGROUND: Eruptive sebaceous hyperplasia is a rare and poorly understood consequence of immunosuppression, most commonly with cyclosporine, followi…
Steroids and the Risk of Venous Thromboembolic Events in Inflammatory Bowel Dis…
PMID: 29293967
Year: 2018
Relationship Type:
Association
Score: 8.3
Editorial: avoiding corticosteroids in the treatment of inflammatory bowel dise…
PMID: 29226421
Year: 2018
Relationship Type:
Treatment
Score: 8.3
Editorial: avoiding corticosteroids in the treatment of inflammatory bowel dise…
PMID: 29226417
Year: 2018
Relationship Type:
Treatment
Score: 8.3
Interstitial Nephritis Secondary to Vedolizumab Treatment in Crohn Disease and …
PMID: 29162338
Year: 2018
Relationship Type:
Treatment
Score: 8.3
Sulfasalazine is an anti-inflammatory agent commonly used in the treatment of autoimmune conditions such as inflammatory bowel disease and rheumatoi…
Comparative safety of systemic and low-bioavailability steroids in inflammatory…
PMID: 29057539
Year: 2018
Relationship Type:
Treatment
Score: 8.3
Pediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the growth of infants and children, but the etiopathogenesi…
Safety Considerations with the Use of Corticosteroids and Biologic Therapies in…
PMID: 28906290
Year: 2017
Relationship Type:
Association
Score: 8.3
BACKGROUND: Stenosis is the most common complication of Crohn's disease (CD). Long-term outcome of patients receiving tumour necrosis factor (TNF) a…
Observational Study of Perspectives of Inflammatory Bowel Disease Patients Conc…
PMID: 28866661
Year: 2018
Relationship Type:
Treatment
Score: 8.3
Perilla frutescens is a culinary and medicinal herb which has a strong anti-inflammatory and antioxidative effects. In the present study, we invest…
The use of oral corticosteroids in inflammatory bowel diseases in Italy: An IG-…
PMID: 28801181
Year: 2017
Relationship Type:
Association
Score: 8.3
Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex tr…
Use of corticosteroids and immunosuppressive drugs in inflammatory bowel diseas…
PMID: 28254463
Year: 2017
Relationship Type:
Mechanism
Score: 8.3
BACKGROUND: Obesity and inflammatory bowel disease (IBD) represent chronic inflammatory conditions. Bariatric surgery improves some obesity-related …