| Drug ID: | Drug3 |
|---|---|
| Drug Name: | Ethanol |
| CID: | 702 |
| DrugBank ID: | DB00898 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT03042091 |
| Molecular Formula: | C2H6O |
| Molecular Weight: | 46.07 g/mol |
| Isomeric SMILES: | CCO |
| Synonyms: | ethanol; ethyl alcohol; alcohol; 64-17-5; grain alcohol; Methylcarbinol; Ethyl hydrate; Tecsol; Algrain; Anhydrol |
| Phase 0: | 27 |
| Phase 1: | 72 |
| Phase 2: | 55 |
| Phase 3: | 29 |
| Phase 4: | 49 |
| Description: | A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem] |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt12 | 702 | Ethanol | 57498 | KIDINS220 | Mus musculus (house mouse) | 30319688 | Ethanol affects the splicing of KIDINS220 mrna|ethanol results in increased expression of KIDINS220 mRNA |
| dt13 | 702 | Ethanol | 63971 | KIF13A | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF13A mrna|ethanol affects the splicing of KIF13A mRNA |
| dt14 | 702 | Ethanol | 23303 | KIF13B | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF13B mRNA |
| dt15 | 702 | Ethanol | 81930 | KIF18A | Mus musculus (house mouse) | 30517762 | [carbon tetrachloride co-treated with ethanol] results in increased expression of KIF18A mRNA |
| dt16 | 702 | Ethanol | 547 | KIF1A | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1A mrna|ethanol affects the splicing of KIF1A mRNA |
| dt17 | 702 | Ethanol | 547 | KIF1A | Mus musculus (house mouse) | 29018328 | Ethanol results in decreased expression of KIF1A mRNA |
| dt18 | 702 | Ethanol | 566766 | kif1ab | Danio rerio (zebrafish) | 29361514 | Ethanol results in increased expression of KIF1AB mRNA |
| dt19 | 702 | Ethanol | 23095 | KIF1B | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1B mrna|ethanol affects the expression of and affects the splicing of KIF1B mRNA |
| dt20 | 702 | Ethanol | 10749 | KIF1C | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1C mRNA |
| dt21 | 702 | Ethanol | 55605 | KIF21A | Mus musculus (house mouse) | 30319688 | Ethanol affects the splicing of KIF21A mRNA |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT01705522 | Multimodal Approach in IBD Patients | None | UNKNOWN | Clinical Hospital Colentina | Ulcerative Colitis|Crohn's Disease|Nonalcoholic F… | None | Details |
| NCT06814600 | Prevalence of Non-Alcoholic Fatty Liver Disease in Inflammatory Bowel Disease Patients | None | RECRUITING | Centre Hospitalier Universitaire Saint Pierre | NAFLD|Inflammatory Bowel Diseases|Steatosis|Fibro… | DIAGNOSTIC_TEST: Transient elastometry | Details |
| NCT04014413 | Safety and Efficacy of Fecal Microbiota Transplantation | None | RECRUITING | Chinese University of Hong Kong | Crohn Disease|Ulcerative Colitis|Celiac Disease|I… | PROCEDURE: Fecal Microbiota Transplantation | Details |
| NCT01476995 | Prognostic Indicators as Provided by the EPIC ClearView | None | COMPLETED | Epic Research & Diagnostics, Inc. | Coronary Artery Disease|Congestive Heart Failure|… | None | Details |
| ACTRN12622000579796 | A single dose, randomised, 2-period, 2-sequence, crossover, relative bioavailability study comparing 2 x 10 mg R-178 tablets with 2 x 10 mg 2-amino-1,7-dihydro-6H-purine-6-thione tablets administered orally in healthy participants under fasting conditions. | PHASE1 | None | Zenith Technology Corporation Limited | 2-amino-1,7-dihydro-6H-purine-6-thione is indicat… | Single dose, crossover study design whereby each … | Details |
| JPRN-UMIN000045216 | Development of intestinal environment evaluation system by integrated analysis of intestinal microbiota research database - Development of intestinal environment evaluation system by integrated analysis of intestinal microbiota research database | Not Available | Recruiting | Department for Medical Innovation and Translational Medical Science, Kyoto Prefectural University of Medicine | healthy individuals without diseases, inflammator… | None | Details |
| IRCT20150304021342N2 | The effects of dietary modification programme (low-fat, low-carb and high-protein diet) on mood status, fatigue and quality of life in patients with ulcerative colitis | Not Available | Not Recruiting | Esfahan University of Medical Sciences | Ulcerative colitis. Ulcerative colitis | Intervention 1: Intervention group: Patients who … | Details |
| NCT04328259 | Prevalance of non_ Alcoholic Fatty Liver Diseases in Patient With Inflammatory Bowel Diseases Attending Assiut University Hospitals | Not Available | Not recruiting | Assiut University | Inflammatory Bowel Disease Patients | None | Details |
| NCT04306939 | Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study | Not Available | Not recruiting | University of Pittsburgh | Chronic Pancreatitis;Inflammatory Bowel Diseases;… | Other: venipuncture;Behavioral: Questionnaires;Ot… | Details |
| ACTRN12618000122257 | The effects of a multidisciplinary Gastroenterology and Hepatology Integrated Care Clinic approach in patients with chronic gastrointestinal disorders: a randomised controlled trial. | Not Available | Recruiting | Princess Alexandra Hospital | Nonalcoholic Fatty Liver Disease;Nonalcoholic Ste… | The Department of Gastroenterology and Hepatology… | Details |
| JPRN-UMIN000019486 | Enterobacterial analysis for the precise medical care (precision medicine) for diabetes, non-alcoholic lipid liver disease / non-alcoholicity fat hepatitis, inflammatory bowel disease, and irritable bowel syndrome. - Enterobacterial analysis for the precise medical care (precision medicine). | Not Available | Recruiting | Kyoto Prefectural University of Medicine | diabetes, non-alcoholic lipid liver disease / non… | None | Details |
| DRKS00004935 | Attitudes towards eCommunication_in treatment of chronically ill patients _ - EC@T | Not Available | Recruiting | Uniklinikum Freiburg, Institut f Qualitsmanagement und Sozialmedizin | Chronic back pain_Chronic ischemic heart disease_… | Group 1: The EC@T-project consists of three subst… | Details |
| NCT01793168 | Coordination of Rare Diseases at Sanford | Not Available | Recruiting | Sanford Health | Rare Disorders;Undiagnosed Disorders;Disorders of… | None | Details |
| ACTRN12609000913279 | Does cognitive-behavioural therapy (CBT) improve outcomes in inflammatory bowel disease (IBD)? A pilot randomised controlled trial | Not Available | Not Recruiting | Royal Adelaide Hospital | Inflammatory bowel disease (IBD); Inflammatory b… | Preliminary screening of interested subjects will… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
Protective effects of Rubus tereticaulis leaves ethanol extract on rats with ul…
PMID: 36375516
Year: 2023
Relationship Type:
Treatment
Score: 6.5
The aim of this study was to evaluate the therapeutic effect of active ethanol extract obtained from the leaves of Rubus tereticaulis (RTME) against …
Evaluation of Anticolitis and Antioxidant Properties of Bixa orellana (Bixaceae…
PMID: 36212166
Year: 2022
Relationship Type:
Treatment
Score: 6.5
BACKGROUND: Ulcerative colitis is an idiopathic inflammatory bowel disease characterized by tissue damage, diarrhea, anemia, and loss of body weight.…
Mesua assamica (King&Prain) kosterm. Bark ethanolic extract attenuates chronic …
PMID: 36195303
Year: 2023
Relationship Type:
Treatment
Score: 6.5
ETHNOPHARMACOLOGICAL RELEVANCE: Mesua Assamica (King & prain) Kosterm. (MA) is an evergreen endemic medicinal tree available in Assam in India and ot…
Ethanol Extracts of Rice Bran and Whole Grain Adlay Seeds Mitigate Colonic Infl…
PMID: 36145253
Year: 2022
Relationship Type:
Association
Score: 6.5
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with frequent relapsing inflammation in the colon. Whole grains have been promoted as…
The ethanol extract of Periplaneta Americana L. improves ulcerative colitis ind…
PMID: 35976342
Year: 2022
Relationship Type:
Treatment
Score: 6.5
PURPOSE: To investigate the effects of Periplaneta americana L. on ulcerative colitis (UC) induced by a combination of chronic stress (CS) and 2,4,6-…
The ethanolic extract of Artemisia anomala exerts anti-inflammatory effects via…
PMID: 35597027
Year: 2022
Relationship Type:
Mechanism
Score: 6.5
BACKGROUND: Artemisia anomala S. Moore (Compositae), known as "Nan-Liu-Ji-Nu" in traditional Chinese medicine (TCM), has been used to treat many infl…
3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR …
PMID: 35336037
Year: 2022
Relationship Type:
Mechanism
Score: 6.5
Understanding the effects induced by carcinogens on primary colonic epithelial cells and how to counteract them might help to prevent colon cancer, w…
Ethanolic extract from Lepidium virginicum L. ameliorates DNBS-induced colitis …
PMID: 35104576
Year: 2022
Relationship Type:
Treatment
Score: 6.5
ETHNOPHARMACOLOGICAL RELEVANCE: Lepidium virginicum L. (Brassicaceae) is a plant widely used in traditional Mexican medicine as an expectorant, diure…
Intestinal Disorder in Zebrafish Larvae (Danio rerio): The Protective Action of…
PMID: 35054518
Year: 2022
Relationship Type:
Mechanism
Score: 6.5
IBD (Inflammatory Bowel Disease) is an inflammatory disease affecting the gastrointestinal tract that is common in both humans and veterinarians. Sev…
Trifolium pratense ethanolic extract alters the gut microbiota composition and …
PMID: 34983484
Year: 2022
Relationship Type:
Treatment
Score: 6.5
BACKGROUND: Trifolium pratense (red clover) ethanolic extract (TPEE) has been used as a popular over-the-counter remedy for the management of menopau…
Ganoderma applanatum polysaccharides and ethanol extracts promote the recovery …
PMID: 34935013
Year: 2022
Relationship Type:
Treatment
Score: 6.5
Inflammatory bowel disease is associated with intestinal homeostasis dysregulation and gut microbiota dysbiosis. This study aimed to investigate the …
Dietary Ethanolamine Plasmalogen Alleviates DSS-Induced Colitis by Enhancing Co…
PMID: 34723501
Year: 2021
Relationship Type:
Treatment
Score: 6.5
Dietary ethanolamine plasmalogen (PlsEtn) has been reported to have several health benefits; however, its functional role during colon pathophysiolog…
Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunct…
PMID: 34658885
Year: 2021
Relationship Type:
Treatment
Score: 6.5
Palmitoylethanolamide (PEA), an endogenous lipid mediator, is emerging as a promising pharmacological agent in multiple neurodegenerative disorders f…
Effectiveness of the fruit of Rosa odorata sweet var. gigantea (Coll. et Hemsl.…
PMID: 34517064
Year: 2022
Relationship Type:
Treatment
Score: 6.5
ETHNOPHARMACOLOGICAL RELEVANCE: Rosa odorata Sweet var. gigantea (Coll. et Hemsl.) Rehd. et Wils (Rosaceae), is also known as "GU-GONG-GUO", the root…
Effects of hydro-ethanolic extract of leaves of Maesa lanceolata (Mursinaceae) …
PMID: 34101116
Year: 2021
Relationship Type:
Treatment
Score: 6.5
Ulcerative colitis is a form of inflammatory bowel disease that is characterized by acute and chronic inflammation. The aim of this work was to evalu…
Engineered Lactobacillus paracasei Producing Palmitoylethanolamide (PEA) Preven…
PMID: 33799405
Year: 2021
Relationship Type:
Treatment
Score: 6.5
Palmitoylethanolamide (PEA) is an N-acylethanolamide produced on-demand by the enzyme N-acylphosphatidylethanolamine-preferring phospholipase D (NAPE…
Alteration of oxidative-stress and related marker levels in mouse colonic tissu…
PMID: 33577585
Year: 2021
Relationship Type:
Mechanism
Score: 6.5
Chronic ethanol consumption is a risk factor for colorectal cancer, and ethanol-induced reactive oxygen species have been suggested to play important…
Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells i…
PMID: 33553930
Year: 2021
Relationship Type:
Mechanism
Score: 6.5
Ethanolamine plasmalogen (PlsEtn) is a subtype of ethanolamine glycerophospholipids (EtnGpl). Recently, PlsEtn has attracted increasing research inte…
Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced …
PMID: 33022343
Year: 2021
Relationship Type:
Treatment
Score: 6.5
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is a relapsing inflammatory disease that still demands for effective remedies due to various …
Ethanolic Garcinia mangostana extract and α-mangostin improve dextran sulfate s…
PMID: 32927006
Year: 2021
Relationship Type:
Treatment
Score: 6.5
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is an inflammatory disorder of the colon. Garcinia mangostana Linn. (GM) has been traditional…