| Drug ID: | Drug3 |
|---|---|
| Drug Name: | Ethanol |
| CID: | 702 |
| DrugBank ID: | DB00898 |
| Modality: | Small Molecule |
| Groups: | approved |
| US Approved: | YES |
| Other Approved: | YES |
| Identifier: | NCT03042091 |
| Molecular Formula: | C2H6O |
| Molecular Weight: | 46.07 g/mol |
| Isomeric SMILES: | CCO |
| Synonyms: | ethanol; ethyl alcohol; alcohol; 64-17-5; grain alcohol; Methylcarbinol; Ethyl hydrate; Tecsol; Algrain; Anhydrol |
| Phase 0: | 27 |
| Phase 1: | 72 |
| Phase 2: | 55 |
| Phase 3: | 29 |
| Phase 4: | 49 |
| Description: | A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem] |
Molecular Structure
Knowledge Graph
| dtID | CID | Compound Name | Gene ID | Gene Name | Species | PubMed IDs | Action |
|---|---|---|---|---|---|---|---|
| dt12 | 702 | Ethanol | 57498 | KIDINS220 | Mus musculus (house mouse) | 30319688 | Ethanol affects the splicing of KIDINS220 mrna|ethanol results in increased expression of KIDINS220 mRNA |
| dt13 | 702 | Ethanol | 63971 | KIF13A | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF13A mrna|ethanol affects the splicing of KIF13A mRNA |
| dt14 | 702 | Ethanol | 23303 | KIF13B | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF13B mRNA |
| dt15 | 702 | Ethanol | 81930 | KIF18A | Mus musculus (house mouse) | 30517762 | [carbon tetrachloride co-treated with ethanol] results in increased expression of KIF18A mRNA |
| dt16 | 702 | Ethanol | 547 | KIF1A | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1A mrna|ethanol affects the splicing of KIF1A mRNA |
| dt17 | 702 | Ethanol | 547 | KIF1A | Mus musculus (house mouse) | 29018328 | Ethanol results in decreased expression of KIF1A mRNA |
| dt18 | 702 | Ethanol | 566766 | kif1ab | Danio rerio (zebrafish) | 29361514 | Ethanol results in increased expression of KIF1AB mRNA |
| dt19 | 702 | Ethanol | 23095 | KIF1B | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1B mrna|ethanol affects the expression of and affects the splicing of KIF1B mRNA |
| dt20 | 702 | Ethanol | 10749 | KIF1C | Mus musculus (house mouse) | 30319688 | Ethanol results in increased expression of KIF1C mRNA |
| dt21 | 702 | Ethanol | 55605 | KIF21A | Mus musculus (house mouse) | 30319688 | Ethanol affects the splicing of KIF21A mRNA |
- No data available
Phase Distribution
Phase Description
- Phase 0: Exploratory trials to assess drug behavior in humans
- Phase 1: Safety trials to determine safe dosage range
- Phase 2: Efficacy trials to evaluate therapeutic effects
- Phase 3: Large-scale trials to confirm efficacy and safety
- Phase 4: Post-marketing surveillance for long-term safety and efficacy
| Trial ID | Title | Phase | Status | Sponsor | Indications | Interventions | |
|---|---|---|---|---|---|---|---|
| NCT01705522 | Multimodal Approach in IBD Patients | None | UNKNOWN | Clinical Hospital Colentina | Ulcerative Colitis|Crohn's Disease|Nonalcoholic F… | None | Details |
| NCT06814600 | Prevalence of Non-Alcoholic Fatty Liver Disease in Inflammatory Bowel Disease Patients | None | RECRUITING | Centre Hospitalier Universitaire Saint Pierre | NAFLD|Inflammatory Bowel Diseases|Steatosis|Fibro… | DIAGNOSTIC_TEST: Transient elastometry | Details |
| NCT04014413 | Safety and Efficacy of Fecal Microbiota Transplantation | None | RECRUITING | Chinese University of Hong Kong | Crohn Disease|Ulcerative Colitis|Celiac Disease|I… | PROCEDURE: Fecal Microbiota Transplantation | Details |
| NCT01476995 | Prognostic Indicators as Provided by the EPIC ClearView | None | COMPLETED | Epic Research & Diagnostics, Inc. | Coronary Artery Disease|Congestive Heart Failure|… | None | Details |
| ACTRN12622000579796 | A single dose, randomised, 2-period, 2-sequence, crossover, relative bioavailability study comparing 2 x 10 mg R-178 tablets with 2 x 10 mg 2-amino-1,7-dihydro-6H-purine-6-thione tablets administered orally in healthy participants under fasting conditions. | PHASE1 | None | Zenith Technology Corporation Limited | 2-amino-1,7-dihydro-6H-purine-6-thione is indicat… | Single dose, crossover study design whereby each … | Details |
| JPRN-UMIN000045216 | Development of intestinal environment evaluation system by integrated analysis of intestinal microbiota research database - Development of intestinal environment evaluation system by integrated analysis of intestinal microbiota research database | Not Available | Recruiting | Department for Medical Innovation and Translational Medical Science, Kyoto Prefectural University of Medicine | healthy individuals without diseases, inflammator… | None | Details |
| IRCT20150304021342N2 | The effects of dietary modification programme (low-fat, low-carb and high-protein diet) on mood status, fatigue and quality of life in patients with ulcerative colitis | Not Available | Not Recruiting | Esfahan University of Medical Sciences | Ulcerative colitis. Ulcerative colitis | Intervention 1: Intervention group: Patients who … | Details |
| NCT04328259 | Prevalance of non_ Alcoholic Fatty Liver Diseases in Patient With Inflammatory Bowel Diseases Attending Assiut University Hospitals | Not Available | Not recruiting | Assiut University | Inflammatory Bowel Disease Patients | None | Details |
| NCT04306939 | Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study | Not Available | Not recruiting | University of Pittsburgh | Chronic Pancreatitis;Inflammatory Bowel Diseases;… | Other: venipuncture;Behavioral: Questionnaires;Ot… | Details |
| ACTRN12618000122257 | The effects of a multidisciplinary Gastroenterology and Hepatology Integrated Care Clinic approach in patients with chronic gastrointestinal disorders: a randomised controlled trial. | Not Available | Recruiting | Princess Alexandra Hospital | Nonalcoholic Fatty Liver Disease;Nonalcoholic Ste… | The Department of Gastroenterology and Hepatology… | Details |
| JPRN-UMIN000019486 | Enterobacterial analysis for the precise medical care (precision medicine) for diabetes, non-alcoholic lipid liver disease / non-alcoholicity fat hepatitis, inflammatory bowel disease, and irritable bowel syndrome. - Enterobacterial analysis for the precise medical care (precision medicine). | Not Available | Recruiting | Kyoto Prefectural University of Medicine | diabetes, non-alcoholic lipid liver disease / non… | None | Details |
| DRKS00004935 | Attitudes towards eCommunication_in treatment of chronically ill patients _ - EC@T | Not Available | Recruiting | Uniklinikum Freiburg, Institut f Qualitsmanagement und Sozialmedizin | Chronic back pain_Chronic ischemic heart disease_… | Group 1: The EC@T-project consists of three subst… | Details |
| NCT01793168 | Coordination of Rare Diseases at Sanford | Not Available | Recruiting | Sanford Health | Rare Disorders;Undiagnosed Disorders;Disorders of… | None | Details |
| ACTRN12609000913279 | Does cognitive-behavioural therapy (CBT) improve outcomes in inflammatory bowel disease (IBD)? A pilot randomised controlled trial | Not Available | Not Recruiting | Royal Adelaide Hospital | Inflammatory bowel disease (IBD); Inflammatory b… | Preliminary screening of interested subjects will… | Details |
| Disease ID | Disease Name | Definition | Category | Related Drugs | Mechanism | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Strategy ID | Therapeutic Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||
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Year: 2020
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Treatment
Score: 6.5
Cyrtocarpa procera is a plant used in traditional Mexican medicine to treat different gastrointestinal problems. Here, we investigated the effects of…
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Score: 6.5
ETHNOPHARMACOLOGICAL RELEVANCE: Piper umbellatum L. leaves, commonly found in the Amazon, Cerrado and Atlantic rain forest regions of Brazil, are wid…
Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeab…
PMID: 31054246
Year: 2019
Relationship Type:
Mechanism
Score: 6.5
BACKGROUND AND AIMS: We aimed to examine, for the first time, the effect of cannabidiol (CBD) and palmitoylethanolamide (PEA) on the permeability of …
Chamomile Methanolic Extract Mitigates Small Bowel Inflammation and ROS Overloa…
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Year: 2019
Relationship Type:
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Score: 6.5
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[Regulatory effect of Tripterygium wilfordii polycoride (TWP) towards TLR4/MyD8…
PMID: 28875676
Year: 2016
Relationship Type:
Mechanism
Score: 6.3
In order to study the regulatory effect of Tripterygium wilfordii polycoride (TWP) towards TLR4/MyD88 independent pathway in TNBS/ethanol ulcerative …
Suppression of IL-8 Release by Sweet Olive Ethanolic Extract and Compounds in W…
PMID: 28671329
Year: 2017
Relationship Type:
Treatment
Score: 6.3
Oxidative stress can stimulate the secretion of pro-inflammatory cytokines. Interleukin-8 (IL-8) has been implicated in the pathogenesis of inflammat…
Ethanolamine Metabolism in the Mammalian Gastrointestinal Tract: Mechanisms, Pa…
PMID: 28429671
Year: 2017
Relationship Type:
Mechanism
Score: 6.3
Nutritional exchanges and cooperation between bacteria in the gastrointestinal tract and the mammalian host play an important role in health and dise…
Effects of methanolic extract from leaves of Rubus imperialis in DSS-induced co…
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Year: 2016
Relationship Type:
Association
Score: 6.3
This study investigated the effects of Rubus imperialis, a berry known as "amora-branca", in colitis dextran sulfate sodium (DSS)-induced in mice. An…
Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatmen…
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Year: 2016
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Score: 6.3
Leukocyte infiltration, improved levels of intercellular adhesion molecule 1 (ICAM-1), and oxidative stress in the colon are the principal factors in…
Total glucosides of peony attenuates 2,4,6-trinitrobenzene sulfonic acid/ethano…
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Year: 2014
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Score: 6.3
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Score: 6.1
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Year: 2012
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Score: 6.1
Studies in animal models and humans suggest anti-inflammatory roles on the N-acylethanolamide (NAE)-peroxisome proliferators activated receptor alpha…
Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran …
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Year: 2012
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Score: 6.1
ETHNOPHARMACOLOGICAL RELEVANCE: Archidendron clypearia Jack. (Fabaceae) has been traditionally used to treat various inflammatory diseases such as pa…
In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper metha…
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Score: 6.1
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[Crohn disease in rats induced by different concentrations of trinitrobenzenesu…
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Year: 2011
Relationship Type:
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Score: 6.1
OBJECTIVE: To induce Crohn disease in rats by intraluminal instillations of different concentrations of 2,4,6-trinitrobenzenesulfonic acid (TNBS) and…
Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by act…
PMID: 22016781
Year: 2011
Relationship Type:
Association
Score: 6.1
BACKGROUND AND AIM: Free radicals are implicated in the aetiology of gastrointestinal disorders such as gastric ulcer, colorectal cancer and inflamma…
Prophylactic treatment with Hypoxis hemerocallidea corm (African potato) methan…
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Year: 2010
Relationship Type:
Treatment
Score: 6.1
Brachyspira hyodysenteriae is the causative agent of swine dysentery and induces a characteristic mucosal inflammation resulting in pronounced typhlo…
Characterization of prokineticin system in Crohn's disease pathophysiology and …
PMID: 37336367
Year: 2023
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Treatment
Score: 5.5
BACKGROUND: Crohn's disease-(CD) pathogenesis is still unknown and chronic pain is a frequent symptom in CD-patients. Identifying novel therapeutic t…
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Year: 2022
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Treatment
Score: 5.5
Ulcerative colitis (UC) is characterized by cycles of active disease flare and inactive disease remission. During UC remission, IL-22 is up-regulated…
The Impact of Alcohol in Inflammatory Bowel Diseases
PMID: 33988227
Year: 2022
Relationship Type:
Mechanism
Score: 5.5
Several environmental factors have been implicated in the pathogenesis of inflammatory bowel diseases (IBD); however, the evidence for alcohol is spa…