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Semaglutide-Induced Small Bowel Pseudo-Obstruction and Ileitis in a Patient With Type 2 Diabetes: A Case Report
Publication Year: 2025 Source: Cureus PMID: 40687404
Type 2 diabetes mellitus is a major health burden globally, with increasing use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) such as semaglutide for glycemic control and cardiovascular risk reduction. While generally well tolerated, GLP-1RAs have been associated with gastrointestinal side effects, including rare reports of bowel obstruction. We describe a …
Increased Risk of Erosive Gastritis Using Oral Sulfate Tablet Bowel Preparation: A Retrospective Single-Center Cohort Study
Publication Year: 2025 Source: Gastroenterology Res PMID: 40687324
BACKGROUND: In 2020, the Food and Drug Administration approved an oral sulfate tablet (OST) containing sodium sulfate, magnesium sulfate, and potassium chloride as a colonoscopy preparation that is more palatable and convenient than polyethylene glycol (PEG) with comparable efficacy. There is a precautionary warning regarding potential risk of mucosal ulcerations …
Inflammatory bowel disease patients believe cannabis and cannabidiol oil relieve symptoms
Publication Year: 2025 Source: Acad Med (San Franc) PMID: 40687272
BACKGROUND: Patients with Inflammatory bowel disease (IBD) often seek alternative therapies for symptom management. This study investigates the perceptions, consumption patterns, and reported outcomes of cannabis and cannabidiol (CBD) oil use among IBD patients and controls. METHODS: A 37-question survey was administered to 139 participants (IBD patients, n = 93; …
Peptide-based therapeutic and delivery strategies for inflammatory bowel disease: challenges and future directions
Publication Year: 2025 Source: RSC Adv PMID: 40686644
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remains a challenging chronic disorder with complex pathophysiology and limited therapeutic options. Peptide-based therapeutics have emerged as promising alternatives, offering high specificity, favorable safety profiles, and unique biological activities compared to traditional treatments. However, challenges including enzymatic degradation, …
Healthcare resource utilization and cost trends in pediatric inflammatory bowel disease within an accountable care organization
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40686249
OBJECTIVE: Healthcare utilization and costs for the inflammatory bowel disease (IBD) population continue to rise nationally. We aimed to describe healthcare utilization and cost trends in children and adolescents with IBD within a pediatric Medicaid accountable care organization (ACO). METHODS: Cross-sectional analysis of inpatient and outpatient insurance claims of known …
Predictors of antitumor necrosis factor primary nonresponse and drug durability in pediatric inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40686240
OBJECTIVES: Antitumor necrosis factor (anti-TNF) therapies are first-line therapies for children with inflammatory bowel disease (IBD) (Crohn's disease [CD], ulcerative colitis [UC] and IBD-unclassified [IBD-U]). Limited studies describing anti-TNFs durability and loss of response in children. This study evaluates predictors of primary Nonresponse and 3-year drug durability in children with …
Noninvasive monitoring with bowel ultrasound (NIMBUS) in paediatric inflammatory bowel disease: Feasibility in a single centre
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40686225
OBJECTIVES: Bowel ultrasound (BUS) is increasingly utilised for monitoring inflammatory bowel disease (IBD), a condition with stringent treatment targets to prevent complications. This study assessed the feasibility of BUS in paediatric IBD and its correlation with established monitoring markers. METHODS: A prospective study was conducted at a specialist paediatric IBD …
[Protective effect of ethyl syringate against ulcerative colitis based on JAK2/STAT3 pathway]
Publication Year: 2025 Source: Zhongguo Zhong Yao Za Zhi PMID: 40686147
To study the therapeutic effect and mechanisms of ethyl syringate(MD) on ulcerative colitis(UC), the MTT assay was used to detect the proliferation inhibition of RAW264.7 cells and HT-29 cells by different concentrations of MD(50, 100, 200, 400 mumol.L~(-1)). UC cell models were constructed by inducing RAW264.7 cells and HT-29 cells …
[Mechanism of Gegen Qinlian Decoction in treatment of ulcerative colitis through affecting bile acid synthesis]
Publication Year: 2025 Source: Zhongguo Zhong Yao Za Zhi PMID: 40686146
Gegen Qinlian Decoction(GQD) is a classic prescription for the clinical treatment of ulcerative colitis(UC). This study, based on the differences in efficacy observed in UC mice under different level of bile acids treated with GQD, aims to clarify the impact of bile acids on UC and its therapeutic effects. It …
[Mechanisms and treatment of inflammation-cancer transformation in colon from perspective of cold and heat in complexity in integrative medicine]
Publication Year: 2025 Source: Zhongguo Zhong Yao Za Zhi PMID: 40686130
Colorectal cancer(CRC) is one of the most common malignant tumors worldwide, primarily originating from recurrent inflammatory bowel disease(IBD). Therefore, blocking the inflammation-cancer transformation in the colon has become a focus in the early prevention and treatment of CRC. The inflammation-cancer transformation in the colon involves multiple types of cells and …
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