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Narrative review on bacteria-derived metabolites in the pathogenesis of ulcerative colitis
Publication Year: 2025 Source: Clin Microbiol Rev PMID: 40689619
SUMMARYThe pathogenesis of ulcerative colitis (UC) is heterogeneous; the causes are considered to be external factors such as stress, infections, antibiotics, and other medications, diet, and intrinsic factors such as genetic predisposition. The aim of this narrative review is to analyze data on intestinal flora and bacteria-derived metabolites in inflammatory …
HMGB1 Exacerbates Intestinal Barrier Damage by Inducing Ferroptosis Through the TLR4/NF-κB/GPX4 Pathway in Ulcerative Colitis
Publication Year: 2025 Source: Mediators Inflamm PMID: 40689397
Background: Intestinal barrier dysfunction and persistent inflammatory response are key pathophysiologic features of ulcerative colitis (UC). High mobility group box-1 protein (HMGB1), an important inflammatory mediator and immunomodulatory factor, has been shown to be involved in the pathogenesis of UC. However, the association between HMGB1 and intestinal barrier dysfunction is …
Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT)
Publication Year: 2025 Source: Curr Res Food Sci PMID: 40689297
BACKGROUND: The development of functional foods with health-promoting properties is a priority in addressing chronic diseases. Studying the effect of these foods on gut microbiota provides critical insights into the interplay between microorganisms, health, and disease. OBJECTIVE: This study aimed to evaluate the effects of fiber-enriched kombucha tea on biochemical …
Successful Use of Upadacitinib, a Selective JAK Inhibitor, in the Treatment of Two Cases of Recalcitrant Chronic Uveitis
Publication Year: 2025 Source: J Ophthalmic Vis Res PMID: 40689111
PURPOSE: Immunomodulatory agents, including conventional immunosuppressive treatment and biologics, are the mainstay of treating chronic uveitis. Janus kinase (JAK) inhibitors, one of the newest biologics, have shown successful outcomes in treating autoimmune diseases such as rheumatoid arthritis and inflammatory bowel diseases by suppressing the JAK/signal transducers and transcription (STAT) pathway. …
Oral olsalazine/ellagic acid/ZnCl(2)-modified in situ-forming hydrogels alleviates anxiety/depression-like symptoms and brain neural activity in colitis mice
Publication Year: 2025 Source: Mater Today Bio PMID: 40688678
Inflammatory bowel disease (IBD) is a kind of chronic non-specific intestinal inflammatory disease, which accompanied by various abnormal psychological states, such as anxiety and depression. Nevertheless, the pathogenesis of IBD with depression is still unclear. Herein, we synthesized an enable a drinkable, liquid in situ-forming hydrogel, which form directly in …
Evaluation of Lacticaseibacillus casei 39 Paraprobiotic in Modulating Inflammatory and Oxidative Pathways in Acetic Acid Induced Ulcerative Colitis
Publication Year: 2025 Source: Food Sci Nutr PMID: 40688608
Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by mucosal inflammation, oxidative stress, and increased apoptosis. This study investigated the therapeutic effects of UV-C-inactivated Lacticaseibacillus casei 39 (paraprobiotic) in an acetic acid-induced UC rat model. The study evaluated its effects on clinical symptoms, inflammatory cytokines, oxidative stress, growth …
Health-promoting effects of Clostridium butyricum GKB7 on the gastrointestinal tract in murine models
Publication Year: 2025 Source: Biochem Biophys Rep PMID: 40688492
Clostridium butyricum is an anaerobic bacterium known for its ability to produce butyrate and modulate gut microbiota. This study aimed to evaluate the protective and regulatory effects of a novel strain, Clostridium butyricum GKB7, isolated from a healthy Taiwanese individual, on gastrointestinal tract. Three rodent disease models were established: picrylsulfonic …
Loss-of-function of lipopolysaccharide-responsive beige-like anchor protein causes inflammatory bowel disease-a case report and literature review
Publication Year: 2025 Source: Transl Pediatr PMID: 40688209
BACKGROUND: Most cases of childhood inflammatory bowel disease (IBD) are polygenic in origin, although a subset of patients exhibits monogenic etiologies. Some studies have identified the lipopolysaccharide-responsive beige-like anchor protein (LRBA) gene as a susceptibility gene, but the majority of research has focused on genetic mutations without extensive clinical data. …
Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases
Publication Year: 2025 Source: Nat Commun PMID: 40681571
The functional characterization of host-gut microbiome interactions remains limited by the sensitivity of current metaproteomic approaches. Here, we present uMetaP, an ultra-sensitive workflow combining advanced LC-MS technologies with an FDR-validated de novo sequencing strategy, novoMP. uMetaP markedly expands functional coverage and improves the taxonomic detection limit of the gut dark …
AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease
Publication Year: 2025 Source: iScience PMID: 40687779
The pathogenic factors of inflammatory bowel disease (IBD) are very complex, and further investigation of its pathogenesis is necessary. Some polar proteins have been reported to perform functions other than maintaining cell structure. In this study, we reported that the polar protein AF6 expressed by intestinal epithelial cells (IEC) can …
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