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Adenoma Detection and the Endoscopist: Assessing the Effects of Insourcing in UK Endoscopy Services
Publication Year: 2025 Source: Cureus PMID: 40612837
Introduction Endoscopy services in the UK often supplement staffing through insourcing, yet the impact of this model on diagnostic outcomes remains unclear. This study evaluates differences in polyp and colorectal cancer detection between standard hospital endoscopists and insourced endoscopists at Sheffield Teaching Hospitals NHS Foundation Trust. Methods A retrospective observational …
The impact of insurance on adolescent transition to adult care
Publication Year: 2025 Source: Health Care Transit PMID: 40613028
BACKGROUND: This study sought to examine how adolescents and young adults with special health care needs (AYA) prepare for managing medical insurance (private and public) as an adult and the role of insurance in locating an adult provider and engaging in care. METHODS: Twenty-eight AYA aged 18-24 years with renal, …
Progress in targeting the NLRP3 signaling pathway for inflammatory bowel disease (Review)
Publication Year: 2025 Source: Mol Med Rep PMID: 40613198
Inflammatory caspases pro‑inflammatory cytokines, such as IL‑1beta IL‑18, constitute a critical part in the modulation of innate immune responses by the nucleotide‑binding domain leucine‑rich repeat protein (NLRP)3 inflammasome. The NLRP3 inflammasome, a cytosolic complex, is composed of three distinct classes of proteins‑sensor complexes, adaptor proteins, cysteine proteases. It is well‑established …
Advances of exosome regulating‑FXR to repair inflammatory bowel disease (Review)
Publication Year: 2025 Source: Int J Mol Med PMID: 40613233
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, poses significant treatment difficulties because of its persistent course and underlying inflammatory mechanisms. Existing treatments primarily focus on alleviating symptoms, while novel biological drugs that target specific molecular pathways could address the root causes of the disease. One such …
When breast cancer spreads below the belt - A case of rectal metastasis from invasive lobular carcinoma
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40613528
We present the case of a 62-year-old woman diagnosed in 2014 with invasive luminal A lobular carcinoma (ILC) of the breast (T3N0M0). She underwent a modified radical mastectomy, followed by radiotherapy and five years of endocrine therapy with letrozole. In 2021, therapy was discontinued due to musculoskeletal side effects. Seven …
Drosophila melanogaster models for investigating inflammatory bowel disease: Methods, pathology, mechanisms, and therapeutic approaches
Publication Year: 2025 Source: Biomol Biomed PMID: 40613543
Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic gastrointestinal inflammation. This paper examines the use of Drosophila melanogaster as a model organism to investigate interactions among the gut microbiota, intestinal stem cells (ISCs), and signaling pathways involved in IBD pathogenesis. Key findings indicate that dysbiosis of the …
Evolving Role of Artificial Intelligence in Endoscopic Management of Inflammatory Bowel Disease: Diagnosis, Surveillance, and Assessment
Publication Year: 2025 Source: Dig Endosc PMID: 40613652
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, presents substantial diagnostic and management challenges because of its variable clinical course and the limitations of conventional endoscopy. Although endoscopic procedures are crucial for diagnosis and surveillance, their inherent subjectivity and inter-observer variability complicate disease assessment. Recent advances in artificial …
The circadian clock, metabolism, and inflammation-the holy trinity of inflammatory bowel diseases
Publication Year: 2025 Source: Clin Sci (Lond) PMID: 40613788
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are characterized by relapsing-remitting immune activation and inflammation within the gastrointestinal tract. The immune system activity displays diurnal variation, which is regulated by the circadian clock. This is achieved by modulating the number of circulating lymphocytes, antibody production, cytokine production, …
New potential biomarkers of ulcerative colitis and disease course - integrated metagenomic and metabolomic analysis among Polish patients
Publication Year: 2025 Source: J Gastroenterol PMID: 40613917
BACKGROUND & AIM: The course of ulcerative colitis (UC) involves successive periods of remission and exacerbation but is difficult to predict. Gut dysbiosis in UC has already been intensively investigated. However, are periods of exacerbation and remission associated with specific disturbances in the composition of the intestinal microbiota and its …
Brain-Gut Communication in Crohn's Disease: Insights From MRI Into Psychological Problems
Publication Year: 2025 Source: J Magn Reson Imaging PMID: 40614053
Crohn's disease (CD) is a chronic nonspecific inflammatory bowel disorder of unknown etiology that may involve any segment of the gastrointestinal tract from the mouth to the anus. Due to its incurability and recurring nature, CD patients often experience psychological comorbidities such as anxiety and depression. The potential link and …
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