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A novel surgical classification system for ileocolic Crohn's disease: "It is not just ileocolic disease"
Publication Year: 2025 Source: Surgery PMID: 40499308
BACKGROUND: Crohn's disease (CD) often affects the terminal ileum, leading to complications such as stricture, fistula, and abscesses, necessitating surgery in up to 80% of patients. Early and effective treatment is crucial to prevent disease progression and improve outcomes, although timing between medical and surgical treatments is challenging. METHODS: This …
TiO(2)/WO(3) nanoarrays photodetector and liposomes equipped with electron donor-mediated signal amplification for immunoassay applications
Publication Year: 2025 Source: Biosens Bioelectron PMID: 40499458
Exploring efficient photoelectric conversion platforms and innovative sensing strategies is the driving force of sensors to realize sensitivity detection. In this work, a photoelectrochemical (PEC) sensor integrating the type-II heterojunction of TiO(2)/WO(3) nanoarrays (NAs) composites and liposome-mediated electron donor equipping strategy, was present for highly sensitive immunoassays. TiO(2)/WO(3) NAs with …
A disposable VHH-based SPR fiber probe for sensitive and specific detection of MMP-9 in cancer and inflammatory disease
Publication Year: 2025 Source: Biosens Bioelectron PMID: 40499460 DOI: 10.1016/j.bios.2025.117684
No Abstract
Unveiling the origins and genetic makeup of the "forgotten people": A study of the Sarmatian-period population in the Carpathian Basin
Publication Year: 2025 Source: Cell PMID: 40499540 DOI: 10.1016/j.cell.2025.05.009
The nomadic Sarmatians dominated the Pontic Steppe from the 3rd century BCE and the Great Hungarian Plain from 50 CE until the Huns' 4th-century expansion. In this study, we present a large-scale genetic analysis of 156 genomes from 1st- to 5th-century Hungary and the Carpathian foothills. Our findings reveal minor …
Orphan receptor GPR39: A potential therapeutic target for inflammatory diseases
Publication Year: 2025 Source: Gene PMID: 40499698
G-protein-coupled receptors (GPCRs) play a pivotal role in mediating responses to various hormones, neurotransmitters, and external stimuli, making them essential therapeutic targets for multiple conditions. GPR39, an orphan GPCR that detects changes in extracellular Zn(2+) levels, is widely expressed in diverse tissues such as the pancreas, gastrointestinal tract, liver, kidneys, …
Comment on "Claudin-2: A marker for a better evaluation of histological mucosal healing in inflammatory bowel diseases"
Publication Year: 2025 Source: Dig Liver Dis PMID: 40500681
No Abstract
Anti-Inflammatory effects of Lactobacillus helveticus and Arthrospira platensis on colonic cells inflamed by Crohn's disease-associated Escherichia coli
Publication Year: 2025 Source: BMC Mol Cell Biol PMID: 40500692 DOI: 10.1186/s12860-025-00545-9
BACKGROUND: Adherent-invasive Escherichia coli (AIEC) is linked to intestinal inflammation in inflammatory bowel disease (IBD). Arthrospira platensis and Lactobacillus helveticus exhibit anti-inflammatory properties individually, yet their effects remain underexplored in IBD-associated inflammation. We aimed to investigate the anti-inflammatory potential of L. helveticus and the hydroalcoholic extract of A. platensis (HA-A. …
Inflammatory bowel disease in Pakistan: Are we looking at it in the eye?
Publication Year: 2025 Source: J Pak Med Assoc PMID: 40500847
No Abstract
Artemisia herba alba: HPLC analysis, ADMET predictions, and anti-inflammatory Activity in chronic colitis model
Publication Year: 2025 Source: J Toxicol Environ Health A PMID: 40501116
Chronic inflammatory bowel diseases (IBDs), particularly colitis, remain a major health burden due to the limitations of current therapies, including adverse effects and diminishing efficacy. Artemisia herba-alba (A. herba-alba), a medicinal plant traditionally used in North Africa and the Middle East, holds promise as a natural anti-inflammatory agent. However, the …
Etrasimod in Treatment of Ulcerative Colitis: A Comprehensive Review
Publication Year: 2025 Source: Turk J Gastroenterol PMID: 40501185
Ulcerative colitis (UC) is a chronic, inflammatory disease of the colon. The unpredictable, systemic, and debilitating nature of UC puts disease management and patient monitoring at a pivotal point. Despite substantial development in pharmacotherapies for UC in recent years, a significant proportion of patients either fail to respond to treatment …
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