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Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model
Publication Year: 2025 Source: Gut Microbes PMID: 40497338 DOI: 10.1080/19490976.2025.2517380
Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied, and the underlying molecular mechanisms remain unknown. In this study, colonization of Il10-deficient mice with Alistipes …
Biomedical Treatment Nanomotors Based on the Intestinal Axis: Current Challenges
Publication Year: 2025 Source: ACS Appl Bio Mater PMID: 40497341 DOI: 10.1021/acsabm.5c00433
The physiological and pathological activities between the intestines and other organs influence each other, which comprise various intestinal axes. In cases of inflammatory bowel disease, the gut microbial homeostasis is imbalanced. These gut microbes and metabolites were also able to cross-talk between different organs along the intestinal axis. Although several …
Mortality and Cancer in Offspring of Mothers With Biopsy-Proven MASLD During Pregnancy: A Nationwide Cohort Study
Publication Year: 2025 Source: Liver Int PMID: 40497679
BACKGROUND & AIMS: Health-related outcomes through early adulthood among offspring prenatally exposed to maternal metabolic dysfunction-associated steatotic liver disease (MASLD) are insufficiently investigated. We aimed to study the risk of mortality and cancer in such offspring. METHODS: This nationwide cohort study included all singleton live born offspring with prenatal exposure …
Unlocking the potential of the low FODMAP diet: comprehensive insights into clinical efficacy, microbiome modulation, and beyond
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 40497754 DOI: 10.1080/17474124.2025.2519160
INTRODUCTION: Functional gastrointestinal disorders (FGIDs) and inflammatory bowel diseases (IBD) present significant challenges for both pediatric and adult populations. The low FODMAP diet (LFD) has gained prominence as an evidence-based dietary intervention, offering symptom relief for abdominal pain, bloating, and altered bowel habits. However, concerns about adherence, nutritional adequacy, and …
Fh15 Reduces Colonic Inflammation and Leukocyte Infiltration in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model
Publication Year: 2025 Source: Cells PMID: 40497975 DOI: 10.3390/cells14110799
Ulcerative colitis (UC) is the most prevalent inflammatory bowel disease (IBD) in the USA. Current treatments present clinical limitations, underscoring the need for innovative therapeutics that promote an anti-inflammatory immune response. This study evaluates the anti-inflammatory potential of Fh15, a recombinant Fasciola hepatica fatty acid binding protein, in a DSS-induced …
Innate Lymphoid Cells in Inflammatory Bowel Disease
Publication Year: 2025 Source: Cells PMID: 40498001 DOI: 10.3390/cells14110825
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder of the gastrointestinal tract with rising incidence and an unclear etiology. Innate lymphoid cells (ILCs) have recently emerged as key regulators of mucosal immunity and tissue homeostasis and are increasingly implicated in IBD. Unlike adaptive …
Absence of Microglial Activation and Maintained Hippocampal Neurogenesis in a Transgenic Mouse Model of Crohn's Disease
Publication Year: 2025 Source: Cells PMID: 40498017
Adult neurogenesis in the hippocampal dentate gyrus (DG) is not only essential for learning and pattern separation, but it is also involved in emotional regulation. This process is vulnerable to local and peripheral inflammation, which is partly mediated by microglia in the DG. As Crohn's disease (CD) is associated with …
Which first? Surgery or biologic therapy for ileocolic Crohn's disease in the real world
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 40498697
BACKGROUND: A laparoscopic ileocolic resection could lead to a better outcome to infliximab for ileocolic Crohn's disease. The aim of this study was to explore real world clinical outcomes in biologic-naive patients with ileocolic Crohn's disease. RESEARCH DESIGN AND METHODS: All patients with ileocolic Crohn's disease treated at our institution …
Uncovering the Single Amino-Acid Polymorphisms of the Human Gut Ecosystem
Publication Year: 2025 Source: J Proteome Res PMID: 40499078
Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation in the gut microbial metagenome and the host genome, but they could not adequately represent the protein-level variants. Single amino-acid polymorphisms (SAP) derived from nonsynonymous SNPs can cause functional changes of proteins and are important forces of adaption. …
Smokers with Crohn's face worse surgical outcomes: A 90-day perioperative analysis
Publication Year: 2025 Source: Am J Surg PMID: 40499212 DOI: 10.1016/j.amjsurg.2025.116458
OBJECTIVE: Smoking is associated with increased severity and recurrence of Crohn's disease (CD), but its impact on perioperative outcomes is unclear. This study evaluated the association between smoking and 90-day postoperative complications in patients with CD undergoing abdominal surgery. METHODS: We conducted a retrospective cohort study (2017-2019) of 294 patients …
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