Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Ultra-small Prussian blue nanodots scavenge reactive oxidative species and balance M1/M2 macrophages to mitigate colitis inflammation
Publication Year: 2025 Source: Nanoscale PMID: 40501333 DOI: 10.1039/d5nr00667h
Inflammatory bowel disease (IBD) is characterized by an overproduction of reactive oxygen species (ROS) and an imbalance in macrophage activity, highlighting the need for innovative treatments that combine anti-inflammatory efficacy with strong clinical potential. We developed ultrasmall Prussian blue nanodots (UPBs) utilizing a novel solvation effect preparation method, achieving quantum …
2'-Fucosyllactose Modulates the Intestinal Immune Response to Gut Microbiota and Buffers Experimental Colitis in Mice: An Integrating Investigation of Colonic Proteomics and Gut Microbiota Analysis
Publication Year: 2025 Source: Food Sci Nutr PMID: 40501496 DOI: 10.1002/fsn3.70418
Inflammatory bowel disease (IBD), a recurrent gastrointestinal disease, is characterized by dysbiosis and inflammation. 2'-fucosyllactose (2'-FL) shows benefits in maintaining gut microenvironment homeostasis. This study aims to investigate the protective mechanism of 2'-FL against experimental IBD using integrated analysis of colonic proteomics and microbiota 16S rRNA sequencing technologies. A murine …
Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism
Publication Year: 2025 Source: Br J Pharmacol PMID: 40437943 DOI: 10.1111/bph.70089
BACKGROUND AND PURPOSE: Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD-patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and efficacy. EXPERIMENTAL APPROACH: Thiopurines were exposed …
The green tea component (-)-epigallocatechin-3-gallate protects against cytokine-induced epithelial barrier damage in intestinal epithelial cells
Publication Year: 2025 Source: Front Pharmacol PMID: 40438590 DOI: 10.3389/fphar.2025.1559812
BACKGROUND: Green tea consumption is associated with health benefits, which are mainly attributed to its catechins, especially the main catechin (-)-epigallocatechin-3-gallate (EGCG). Among other beneficial effects, EGCG was shown to be protective in inflammatory bowel disease (IBD), a condition associated with barrier dysfunction. To elucidate the mechanisms behind this, the …
Diverse phenotypic manifestations of small intestinal mucosa in non-infectious common variable immunodeficiency bowel disease: A case report
Publication Year: 2025 Source: World J Gastrointest Endosc PMID: 40438712
BACKGROUND: Common variable immunodeficiency (CVID) is a primary antibody immunodeficiency disorder characterized by diminished IgG levels. Despite ongoing research, the precise pathogenesis of CVID remains unclear. Genetic factors account for only 10%-20% of cases, with an estimated incidence of 1 in 10000 to 1 in 100000, affecting individuals across all …
Towards precision care: Fluctuations in albumin and fibrinogen as noninvasive predictors of endoscopic outcomes in Crohn's disease
Publication Year: 2025 Source: World J Gastrointest Endosc PMID: 40438718
In this article, we comment paper by Wang et al published recently. The study represents a notable step in the pursuit of precision medicine for inflammatory bowel diseases, offering valuable insights into the potential of noninvasive biomarkers for Crohn's disease (CD) management. This article highlights the significance of the findings, …
Effect of Self-Care Education on Lifestyle and Quality of Life in Patients With Inflammatory Bowel Diseases: A Comparison Between a Smartphone Application and Teach-Back
Publication Year: 2025 Source: Gastroenterol Nurs PMID: 40439903 DOI: 10.1097/SGA.0000000000000867
This randomized clinical trial was conducted with the aim of comparing the effect of self-care education through two methods, a smartphone application (app) and teach-back (TB), on lifestyle and quality of life (QoL) in patients with inflammatory bowel diseases (IBD). This three-stage randomized clinical trial was conducted among 90 patients …
Inflammatory Bowel Disease on TikTok: Utilizing the Platform for Information on Ostomies, Advocacy, and Disease Management
Publication Year: 2025 Source: Gastroenterol Nurs PMID: 40439904 DOI: 10.1097/SGA.0000000000000863
TikTok has gained popularity among young adults. Individuals with inflammatory bowel disease (IBD), a chronic autoimmune disease commonly diagnosed between ages of 15 and 29, often use multiple social media platforms for medical information and support. This study aimed to assess the content and quality of the most viewed TikTok …
Prevalence of inflammatory skin disorders in patients with inflammatory bowel disease (IBD)
Publication Year: 2025 Source: Arch Dermatol Res PMID: 40439921 DOI: 10.1007/s00403-025-04282-z
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, which primarily affects the gut, but is not restricted to the intestinal tract. IBD is result of a complex interplay between a dysfunctional host immune response and environmental triggers. Extraintestinal manifestations (EIMs) are frequently observed in patients with IBD. The aim …
Oral Peptide Therapeutics as an Emerging Treatment Modality in Immune-Mediated Inflammatory Diseases: A Narrative Review
Publication Year: 2025 Source: Adv Ther PMID: 40439953
Immune-mediated inflammatory diseases (IMIDs), such as psoriasis, psoriatic arthritis, and inflammatory bowel disease, encompass a heterogenous group of conditions associated with chronic inflammation. Systemic treatments for patients with IMIDs include parenterally delivered monoclonal antibodies (mAbs) that disrupt specific cytokine and cytokine receptor binding interactions, and orally delivered small molecules that …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide