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IBUS-SAS Is a Highly Accurate Intestinal Ultrasound Score for Predicting Endoscopic Disease Activity in Ulcerative Colitis
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40440217 DOI: 10.1002/ueg2.70053
BACKGROUND: The international bowel ultrasound group-segmental activity score (IBUS-SAS) is a validated tool with high interobserver agreement for accurately detecting disease activity in Crohn's disease (CD). Here, we addressed whether the IBUS-SAS is also suitable to assess disease activity in ulcerative colitis (UC). METHODS: The IBUS-SAS and Limberg scores were …
Heat shock transcription factor 2 reduces mitochondrial pathway apoptosis in intestinal epithelial cells by inhibiting the increase in mitochondrial membrane permeability in ulcerative colitis
Publication Year: 2025 Source: PLoS One PMID: 40440295
The destruction of intestinal mucosal mechanical barrier homeostasis caused by excessive apoptosis of intestinal epithelial cells (IECs) is an important reason for the occurrence and development of ulcerative colitis (UC). The increase in mitochondrial membrane permeability caused by the opening of the mitochondrial membrane permeability transition pore (mPTP) is a …
The role of IL-39 in autoimmune diseases: From general to immunopathogenesis
Publication Year: 2025 Source: Cytokine PMID: 40440970 DOI: 10.1016/j.cyto.2025.156969
IL-39, a cytokine from the IL-12 family that appears to be produced primarily by B cells, consists of the IL-23p19 and Ebi3 subunits, which signal through IL-23R/gp130 to activate STAT1/STAT3. Some studies suggest elevated IL-39 levels in certain autoimmune conditions, such as relapsing-remitting multiple sclerosis (RRMS), ankylosing spondylitis (AS), and …
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells
Publication Year: 2025 Source: Mol Immunol PMID: 40441031 DOI: 10.1016/j.molimm.2025.05.015
Inflammatory Bowel Disease (IBD), is a chronic illness characterized by severe abdominal pain, diarrhea, and weight loss, seriously diminishing patients' quality of life. Andrographolide (AND), a natural diterpenoid from Andrographis paniculata, and its sulfated metabolite, andrographolide sodium bisulfite (ASB), have showed potential anti-inflammatory effects. However, their mechanism in IBD remains …
Blood metabolomic and Crohn's disease: A Mendelian randomization study
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40441191
Crohn's disease, a type of inflammatory bowel disease, is marked by chronic inflammation of the gastrointestinal tract, leading to symptoms like abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. The pathophysiology of Crohn's disease is complex and not fully understood, with recent studies suggesting a potential role for metabolic …
Synthesis and characterization of 5-aminosalicylic acid-azobenzyl-chitosan conjugates-based prodrugs for the colon targeted delivery in dextran sodium sulfate (DSS)-induced ulcerative colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40441567
Site-specific colon drug delivery is crucial in the treatment of colon-localized diseases. In this study, prodrugs of 5-aminosalicylic acid (5-ASA), the drug of choice in ulcerative colitis (UC), were synthesized by conjugating with chitosan having molecular weights (MW) of 30, 80 and 300 kDa to achieve targeted delivery to the …
Structural characteristics of Phaeodactylum tricornutum polysaccharides and the effects on DSS-induced colitis via improving the intestinal barrier and modulating the gut microbiota
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40441573
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by bloody diarrhea and colonic inflammation. Although Phaeodactylum tricornutum polysaccharides (PTPs) possess anti-inflammatory and immunostimulatory properties, the effects on colonic inflammation remain unclear. This study investigated the molecular structure of PTPs and their potential effects in dextran sulfate sodium (DSS)-induced colitis …
Prenatal stress and cortical morphometric similarity network in offspring: Transcriptional signatures of associated genes
Publication Year: 2025 Source: J Affect Disord PMID: 40441652 DOI: 10.1016/j.jad.2025.119519
BACKGROUND: Prenatal stress is known to disrupt neurodevelopment in offspring, heightening their risk of mental health disorders. However, its impact on the morphometric similarity network (MSN)-a framework that integrates multiple anatomical features to quantify structural similarity across brain regions in the developing offspring-remains poorly understood. METHODS: Using data from the …
A dual-polysaccharide (carboxylated chitosan-carboxymethyl cellulose sodium) gastrointestinal dynamic response in situ hydrogel for optimized oral targeted inflammatory bowel disease therapy
Publication Year: 2025 Source: Carbohydr Polym PMID: 40441821 DOI: 10.1016/j.carbpol.2025.123704
Hydrogels characterized by a three-dimensional polymer network are promising vehicles for oral colon-targeted drug delivery, yet conventional systems relying on intragastric cross-linking agents face clinical limitations. Here, we present a cross-linker-independent oral in situ hydrogel (CCS/CMC-Na) functionalized with Ti(3)C(2) MXene nanosheets for optimized inflammatory bowel disease (IBD) therapy. The CCS/CMC-Na …
Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases
Publication Year: 2025 Source: J Biomed Res PMID: 40441863
The comorbidity of skin and gastrointestinal tract (GIT) diseases, primarily driven by the gut-skin axis (GSA), is well-known. However, the genetic contribution to the GSA remains unclear. Here, using genome-wide association study (GWAS) summary statistics from European populations, we performed genome-wide pleiotropic analysis to investigate the shared genetic basis and …
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