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Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling
Publication Year: 2025 Source: Gut PMID: 40441864 DOI: 10.1136/gutjnl-2025-334938
The intricate interplay between the gut microbiota and the GI tract has garnered significant attention, as growing evidence has identified the inflammasome as a crucial yet underexplored master regulator in microbiota-driven diseases. Triggered by a variety of dangers, inflammasomes are supramolecular complexes that regulate immune response. A large number of …
Combining multiscale replication in network and landscape genetic analyses to assess functional connectivity and population resilience in Parnassius clodius butterflies
Publication Year: 2025 Source: J Hered PMID: 40442020 DOI: 10.1093/jhered/esaf033
Characterizing functional connectivity is an important challenge in the face of ongoing environmental change. Approaches combining landscape genetic and network methodologies have shown promise in allowing for simultaneous identification of strong and vulnerable populations, and the landscape factors that may inhibit or facilitate population connectivity. Here we leverage these tools …
Comparative analysis of natural language processing methodologies for classifying computed tomography enterography reports in Crohn's disease patients
Publication Year: 2025 Source: NPJ Digit Med PMID: 40442294 DOI: 10.1038/s41746-025-01729-5
Imaging is crucial to assess disease extent, activity, and outcomes in inflammatory bowel disease (IBD). Artificial intelligence (AI) image interpretation requires automated exploitation of studies at scale as an initial step. Here we evaluate natural language processing to classify Crohn's disease (CD) on CTE. From our population representative IBD registry …
Functional and Physiological Implications of Oligopeptide Transporters: Potential Targets for Pharmacological Interventions
Publication Year: 2025 Source: J Membr Biol PMID: 40442308 DOI: 10.1007/s00232-025-00348-1
Peptide transporters are important plasma membrane proteins that facilitate the cellular uptake of di- and tripeptides in addition to various peptidomimetic drugs. The proton-coupled oligopeptide transporter (POT) family consists of mainly four transporter proteins, which include two H(+) -coupled oligopeptide transporters known as PEPT1 (SLC15A1) and PEPT2 (SLC15A2), along with …
Association between the immune-inflammation index and the severity and clinical outcomes of patients with inflammatory bowel disease: a systematic review and meta-analysis
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40442599 DOI: 10.1186/s12876-025-04033-4
BACKGROUND: Existing studies have explored the association between immune-inflammatory indices and inflammatory bowel disease (IBD), but there is a lack of comprehensive evidence. This meta-analysis and systematic review seeks to synthesize the data of available clinical research and offer the latest and comprehensive evidence-based conclusions regarding whether these immune-inflammatory indices …
Prevalence of osteoporosis in patients with inflammatory bowel disease: a systematic review and meta-analysis
Publication Year: 2025 Source: J Health Popul Nutr PMID: 40442831 DOI: 10.1186/s41043-025-00946-8
BACKGROUND: Although prior studies alluded to the association between inflammatory bowel disease (IBD) and osteoporosis, the exact prevalence of osteoporosis in this patient population remains variably reported. Therefore, we aimed to systematically explore the overall prevalence of osteoporosis in patients with IBD. METHODS: We searched in Embase, PubMed, and Scopus, …
PTPN2 and Leukopenia in Individuals With Normal TPMT and NUDT15 Metabolizer Status Taking Azathioprine
Publication Year: 2025 Source: Clin Transl Sci PMID: 40442974
Leukopenia is a common dose-dependent side effect of azathioprine, often leading to drug discontinuation. Variants in TPMT and NUDT15 are associated with azathioprine-induced leukopenia but only explain 25% of cases. Thus, we aimed to identify novel genetic risk factors among TPMT and NUDT15 normal metabolizers through a genome-wide association study …
Mid-Term Outcomes of Valve-Sparing Repair With Intraoperative Balloon Dilation in Tetralogy of Fallot
Publication Year: 2025 Source: World J Pediatr Congenit Heart Surg PMID: 40443166 DOI: 10.1177/21501351251321528
BackgroundLate sequelae associated with chronic severe pulmonary regurgitation (PR) following transannular patch (TAP) repair of tetralogy of Fallot (TOF) have driven the use of alternative approaches. This study investigates mid-term pulmonic valve (PV) durability in TOF patients who underwent valve-sparing repair with intraoperative balloon dilation (VS-IBD).MethodsBetween 2010 and 2022, 139 …
Role of Novel Target Molecules (β-Catenin and Retinoblastoma Protein) in the Spectrum of Inflammatory Bowel Disease
Publication Year: 2025 Source: Cureus PMID: 40443602 DOI: 10.7759/cureus.83162
Background Inflammatory bowel disease (IBD) has been a worldwide health care challenge with a continually increasing incidence in India. Spectrum of IBD mainly includes ulcerative colitis (UC) and Crohn's disease (CD). Pharmacological and surgical treatments differ widely in CD and UC; hence, establishment of a correct diagnosis is of paramount …
The Application of a Novel Intense Pulsed Light in the Treatment of Rosacea-Like Mice
Publication Year: 2025 Source: Lasers Surg Med PMID: 40444441
OBJECTIVES: Rosacea is a chronic inflammatory disease that severely affects the quality of life of patients. Intense pulsed light (IPL) has been widely used in treating the erythema and telangiectasia in rosacea patients. However, the mechanism of its use is poorly understood. Our study objectives were to (i) assess the …
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