Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Impaired physical fitness in pediatric inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40444501
OBJECTIVE: There are only a few studies on physical fitness in pediatric inflammatory bowel disease (PIBD). We compared physical fitness in PIBD patients versus healthy controls and analyzed the role of contributing disease- and patient-related factors. METHODS: This cross-sectional study included 73 patients with PIBD aged 13.0 (2.8) (mean [standard …
Cyclosporine A-Loaded Poly(ethylene glycol)-block-poly(lactic-co-glycolic acid)-Based Mucopenetrating Nanoparticles for Treatment of Inflammatory Bowel Diseases
Publication Year: 2025 Source: ACS Appl Bio Mater PMID: 40445034 DOI: 10.1021/acsabm.5c00439
This study aimed to develop cyclosporine A (CsA)-loaded mucopenetrating nanoparticles (MNP) for the safe and effective treatment of inflammatory bowel diseases (IBD). Poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (PEG-PLGA) was selected as the mucopenetrating carrier polymer for CsA/MNP to achieve topical accumulation by passive targeting and prolonged pharmacological action at the inflammation site, …
Carbon footprint of common procedures in inflammatory bowel disease
Publication Year: 2025 Source: Tech Coloproctol PMID: 40445247 DOI: 10.1007/s10151-025-03123-5
BACKGROUND: The aim of this study was to assess the environmental impact, primarily the carbon footprint of the most common procedures in inflammatory bowel disease (IBD). METHODS: In this study, all processes and products used during a total of eight laparoscopic ileocecal resections (ICRs) in patients with Crohn's disease (CD), …
Pay Me Now or Pay Me Later-Meeting Unmet Needs Among Patients with IBD
Publication Year: 2025 Source: Dig Dis Sci PMID: 40445463 DOI: 10.1007/s10620-025-09097-6
No Abstract
Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS
Publication Year: 2025 Source: PLoS One PMID: 40446056
Previous genome-wide association studies (GWAS) have identified various risk variants for ulcerative colitis (UC), but there is a lack of evidence showing how these variants contribute to the development of UC. We employed an integrated pipeline to effectively translate genetic associations in order to identify pathogenic genes for UC.By combining …
The sympathetic neurons in the gut: Perspectives on metabolic and immune health and diseases
Publication Year: 2025 Source: Curr Opin Neurobiol PMID: 40446451 DOI: 10.1016/j.conb.2025.103051
PURPOSE OF REVIEW: The sympathetic nervous system (SNS), a crucial regulator of systemic homeostasis, connects the brain and peripheral organs through complex neural circuits. Often termed the "second brain," the gut responds to sympathetic innervation to coordinate physiological processes such as digestive motility, nutrient absorption, and immune surveillance, unveiling fundamental …
The promoting effect of high-fat diet-induced trained immunity on ulcerative colitis and the mechanism of the therapeutic effect of Dahuang Mudan Decoction
Publication Year: 2025 Source: Phytomedicine PMID: 40446577
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease driven by intestinal immune imbalance. In addition, its pathogenesis includes environment, genetics, microbiota, genes, and diet. Epidemiological and related studies have shown that a high-fat diet habit can promote the progression of UC. The trained immunity induced by a high-fat diet …
BAP1 exacerbates inflammatory bowel disease by promoting ferroptosis via SLC7A11 suppression
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40446694 DOI: 10.1016/j.intimp.2025.114957
OBJECTIVE: This study aimed to elucidate the role of BAP1 in inflammatory bowel disease (IBD) and elucidate the underlying mechanism. METHODS: A colitis model was established in C57BL/6 mice with dextran sulfate sodium (DSS) and in the HT-29 cell line. Ferroptosis-related gene expression was analyzed via RNA sequencing, qRT-PCR, and …
An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastroenterology PMID: 40446946 DOI: 10.1053/j.gastro.2025.05.015
BACKGROUND & AIMS: Approval of new therapies for inflammatory bowel disease (IBD) requires rigorously designed and well-executed randomized controlled trials (RCTs). Corticosteroids remain a cornerstone of IBD induction therapy, and many patients in trials are enrolled while taking corticosteroids. Despite this, approaches to corticosteroid management in RCTs have been highly …
Metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease: prevalence, risk factors, pathophysiological pathways and clinical consequences
Publication Year: 2025 Source: Expert Rev Clin Immunol PMID: 40447559 DOI: 10.1080/1744666X.2025.2514605
INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver comorbidity in patients with inflammatory bowel disease (IBD). AREAS COVERED: This paper outlines common pathophysiological aspects related to MASLD and IBD; describes the epidemiological clues associated with both diseases; analyzes risk factors contributing to MASLD appearance and progression …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide