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Shikonin inhibits NLRP3 inflammasome activation and controls inflammatory disease
Publication Year: 2025 Source: Sci Rep PMID: 40447675
Shikonin (SHK) is a plant-derived naphthoquinone known for its anti-inflammatory activity, though the mechanism remains largely unexplored. The NLRP3 inflammasome, one of the most studied inflammasomes, can cause uncontrolled inflammation and drive various diseases when dysregulated. Here, we confirmed that SHK specifically abolished NLRP3 inflammasome activation by suppressing caspase-1 maturation …
Human placenta mesenchymal stromal cells alleviate intestinal inflammation and repair intestinal barrier function by activating AMPK-FXR pathway
Publication Year: 2025 Source: Commun Biol PMID: 40447793
Crohn's disease (CD) has a complex pathogenesis; there is currently no effective treatment. Mesenchymal stromal cells (MSCs) are a potential therapeutic option for CD. It is important to systematically evaluate the safety and effectiveness of MSCs and their mechanism for the treatment of CD to support their clinical application. Here, …
The IL-22-oncostatin M axis promotes intestinal inflammation and tumorigenesis
Publication Year: 2025 Source: Nat Immunol PMID: 40447860
Multicellular cytokine networks drive intestinal inflammation and colitis-associated cancer (CAC). Interleukin-22 (IL-22) exerts both protective and pathogenic effects in the intestine, but the mechanisms that regulate this balance remain unclear. Here, we identify that IL-22 directly induces responsiveness to the IL-6 family cytokine oncostatin M (OSM) in intestinal epithelial cells …
A case of IgA nephropathy associated with Crohn's disease treated with enteric-coated budesonide
Publication Year: 2025 Source: CEN Case Rep PMID: 40447912
The gut-kidney axis has recently gained attention as a pathogenesis of IgA nephropathy (IgAN). In fact, the efficacy of target-release formulation of budesonide for IgAN has been reported in recent studies. On the other hand, there have been no reports yet on the efficacy of enteric-coated budesonide for IgAN complicated …
IL-36 signaling as a drug target in Crohn's disease patients with IL36RN mutations
Publication Year: 2025 Source: EMBO Mol Med PMID: 40447918
The IL-36 signaling pathway has recently been identified as a key regulator of intestinal homeostasis and inflammation. However, the role of mutations in the IL-36R signaling pathway in the pathogenesis of inflammatory bowel disease remains unclear. We here identified four Crohn's disease patients with heterozygous missense mutations in the IL-36 …
Cross-Trait Cross-Genome Cross-Organ Analysis of Gastrointestinal Disorders and Depression
Publication Year: 2025 Source: Dig Dis Sci PMID: 40447981 DOI: 10.1007/s10620-025-09083-y
BACKGROUND: The aim of this study was to explore the shared genetic architecture between inflammatory bowel disease and depression and other upper gastrointestinal dysfunctions and inflammatory diseases, and to identify shared risk loci, potential key tissues, and associated genetic mechanisms to study. METHODS: Based on pooled data from a large-scale …
A novel inflammatory biomarker in assessing disease activity in ulcerative colitis: gasdermin D
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40447992
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease with a worldwide prevalance of around 5 million patients. Assessment of disease activity is crucial in management of UC patients. Gasdermin D (GSDMD) is a protein which belongs to the gasdermin protein family and plays a role in inflammatory cell death, …
Seroprevalence of CMV infection in patients with active ulcerative colitis and underlying factors of pathogenicity
Publication Year: 2025 Source: BMC Infect Dis PMID: 40448012 DOI: 10.1186/s12879-025-11156-2
BACKGROUND: Cytomegalovirus (CMV) infection has garnered increasing attention in the context of active ulcerative colitis (UC), a chronic IBD, characterized by periods of remission and relapse. Exploring the interplay between CMV and UC highlights the need for heightened awareness of viral infections in gastrointestinal disorders, to improve patient management and …
Effectiveness of an app-based walking program for obese patients with inflammatory bowel disease in Korea: a single-blind parallel-group randomized clinical trial
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40448025 DOI: 10.1186/s12876-025-03962-4
BACKGROUND: Obesity in patients with inflammatory bowel disease (IBD) not only exacerbates symptoms but also interferes with treatment and leads to additional complications. Therefore, managing weight loss and preventing obesity are crucial. This study was designed to develop and implement a 10-week walking exercise program, facilitated by a mobile application, …
Advanced oral drug delivery systems for gastrointestinal targeted delivery: the design principles and foundations
Publication Year: 2025 Source: J Nanobiotechnology PMID: 40448152
Oral administration has long been considered the most convenient method of drug delivery, requiring minimal expertise and invasiveness. Unlike injections, it avoids discomfort, wound infections, and complications, leading to higher patient compliance. However, the effectiveness of oral delivery is often hindered by the harsh biological barriers of the gastrointestinal tract, …
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