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IgA nephropathy in a patient with inflammatory bowel disease
Publication Year: 2024 Source: Indian J Gastroenterol PMID: 38753227
No Abstract
Correction to: Correlation Between Plasma and Fecal Biomarkers and Patient‑Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis
Publication Year: 2024 Source: Dig Dis Sci PMID: 38753242 DOI: 10.1007/s10620-024-08469-8
No Abstract
6-Gingerol ameliorates ulcerative colitis by inhibiting ferroptosis based on the integrative analysis of plasma metabolomics and network pharmacology
Publication Year: 2024 Source: Food Funct PMID: 38753306
No Abstract
The degree of bowel remission predicts phenotype progression in Crohn's disease
Publication Year: 2024 Source: United European Gastroenterol J PMID: 38753521 DOI: 10.1002/ueg2.12581
BACKGROUND: Patients with Crohn's disease (CD) are at risk of progressing from inflammatory to stricturing and penetrating phenotypes. The influence of the depth of remission on the risk of progression has not been adequately evaluated. METHODS: A retrospective cohort study including surgically naive CD patients with inflammatory phenotype evaluated concomitantly …
Risk of disease flare in spondyloarthritis patients after tapering tumor necrosis factor inhibitors: A meta-analysis and literature review
Publication Year: 2024 Source: Int Immunopharmacol PMID: 38754279 DOI: 10.1016/j.intimp.2024.112167
BACKGROUND: Tumor necrosis factor inhibitors (TNFis) have shown dramatic benefit in patients with spondyloarthritis (SpA). Tapering of TNFi medication may be considered in patients with sustained low disease activity because continued use of TNFis at standard doses may increase the risk of side effects including infections and impose an economic …
Evaluation of Deficient Nutrients in Infants and Toddlers Mainly Taking Amino Acid-Based Elemental Formulas: An Exploratory Study
Publication Year: 2024 Source: Ann Nutr Metab PMID: 38754393 DOI: 10.1159/000539146
INTRODUCTION: This study evaluated nutrient deficiencies in infants and toddlers with inflammatory bowel disease (IBD) and eosinophilic gastrointestinal disorders (EGIDs), whose primary nutritional source is elemental formulas (EFs). METHODS: The nutrient status of children with IBD and EGID aged 6 months to 6 years was evaluated. RESULTS: Twenty-one children fed …
The immune suppressive functions of macrophages are impaired in patients with ulcerative colitis
Publication Year: 2024 Source: Immunol Lett PMID: 38754636 DOI: 10.1016/j.imlet.2024.106867
Chronic inflammation is the pathological feature of inflammatory bowel diseases (IBD), but its etiology is unknown. Macrophages are one of the major immune cell fractions in the colon. The objectives of this study are to characterize the immune regulatory functions of macrophages in the colon of patients with ulcerative colitis …
The Progression of Microbiome Therapeutics for the Management of Gastrointestinal Diseases and Beyond
Publication Year: 2024 Source: Gastroenterology PMID: 38754739 DOI: 10.1053/j.gastro.2024.05.004
There has been an increased ability to investigate the human microbiota through next-generation sequencing and functional assessment. This advancement has rapidly expanded our ability to study and manipulate the gastrointestinal microbiome to mitigate disease. Fecal microbiota transplantation, a therapy that broadly transfers the entire intestinal ecosystem, has been explored as …
Novel biomarker profiles to improve individual diagnosis and prognosis in patients with suspected inflammatory bowel disease: protocol for the Nordic inception cohort study (NORDTREAT)
Publication Year: 2024 Source: BMJ Open PMID: 38754881 DOI: 10.1136/bmjopen-2023-083144
INTRODUCTION: Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, can be challenging to diagnose, and treatment outcomes are difficult to predict. In the NORDTREAT cohort study, a Nordic prospective multicentre study, we aim to identify novel molecular biomarkers of diagnostic value by assessing the diagnostic test accuracy (cross-sectionally), …
Granzyme B PET Imaging for Assessment of Disease Activity in Inflammatory Bowel Disease
Publication Year: 2024 Source: J Nucl Med PMID: 38754959 DOI: 10.2967/jnumed.123.267344
Developing a noninvasive imaging method to detect immune system activation with a high temporal resolution is key to improving inflammatory bowel disease (IBD) management. In this study, granzyme B (GZMB), typically released from cytotoxic T and natural killer cells, was targeted using PET with (68)Ga-NOTA-GZP (where GZP is beta-Ala-Gly-Gly-Ile-Glu-Phe-Asp-CHO) to …
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