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Long-Term Follow-Up After Acute Gastroenteritis Caused by Giardia Infection in Juvenile Dogs
Publication Year: 2025 Source: J Vet Intern Med PMID: 40448678 DOI: 10.1111/jvim.70123
BACKGROUND: In humans, there is a high prevalence of postinfectious irritable bowel syndrome (IBS) after acute giardiasis. OBJECTIVE: To evaluate the prevalence of chronic gastrointestinal and dermatologic signs in dogs after acute Giardia-associated gastroenteritis. ANIMALS: Forty-nine dogs with acute gastroenteritis and confirmed Giardia infection and fifty control dogs without a …
Systematic Evaluation of Australian Risk Management Plans for Biologic Medicines
Publication Year: 2025 Source: Drug Saf PMID: 40448798
BACKGROUND: Risk management plans (RMPs) are a critical element of pharmacovigilance. However, few studies have examined the quality and type of information included in RMPs, and none has examined the RMPs in the Australian medicines regulatory context. OBJECTIVES: This study aims to characterise safety concerns, particularly missing information listed in …
Improvement of anti-inflammatory efficacy of apigenin by shrimp (Penaeus vannamei) powder/κ-carrageenan hydrogel in dextran sulfate sodium-induced colitis
Publication Year: 2025 Source: Food Chem PMID: 40449394
Shrimp (Penaeus vannamei) powder/kappa-carrageenan (SP/KC) hydrogel was used to improve the anti-inflammatory efficacy of apigenin (API) with elastic gel properties and dense honeycomb microstructures. Ulcerative colitis (UC) mice were gavaged with API and SP/KC/API, respectively, to evaluate the effectiveness of SP/KC. Compared with API group, the weight loss and colon …
The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination
Publication Year: 2025 Source: Cell Commun Signal PMID: 40450320 DOI: 10.1186/s12964-025-02260-6
BACKGROUND: Regulation of the nuclear factor-kappa B (NF-kB) signaling pathway is a major host homeostatic mechanism for controlling hyper-inflammation or chronic inflammation. Despite extensive research, the regulatory factors of NF-kB signaling required to preserve homeostasis and control inflammatory disorders are not fully understood. Moreover, the role of MARCH2 in chronic …
One-year remission of therapy-resistant SLE after a single course with the bispecific CD3: BCMA antibody teclistamab, but induction of a non-infectious Crohn's-like inflammatory bowel disease
Publication Year: 2025 Source: Ann Rheum Dis PMID: 40450406
No Abstract
The impact of climate, weather, seasonal transitions, and diurnal rhythms on gut microbiota and immune homeostasis
Publication Year: 2025 Source: Antonie Van Leeuwenhoek PMID: 40450648 DOI: 10.1007/s10482-025-02097-6
The influence of meteorological environmental factors such as climate change, weather alterations, seasonal transitions, and diurnal cycles on human health is becoming increasingly evident, particularly through their modulation of the gut microbiome and immune homeostasis. The human gut microbiota maintains immune homeostasis and regulates various physiological and metabolic functions by …
Higher Prescribed Opioid Use Among Adults With Crohn's Disease Than General Population: A Nationwide Cohort Study in Sweden 2006-2021
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40450700
BACKGROUND AND AIMS: Population-based data on prescribed opioid use among adults with Crohn's disease (CD) remain limited. METHODS: This nationwide register-based study included individuals >/= 18 years with incident (2008-2019) or prevalent (2008-2021) CD and up to 10 individually matched reference individuals without inflammatory bowel disease. We categorised opioid dispensations …
Effect of preoperative exercise on postoperative complications after colorectal cancer surgery in older people with low physical fitness: The CANOPTIPHYS randomised controlled trial
Publication Year: 2025 Source: J Geriatr Oncol PMID: 40450796
INTRODUCTION: Preoperative exercise may decrease the risk of complications after major abdominal cancer surgery but the amount of time available for such interventions is limited. Our objective was to evaluate the effect of a short-term preoperative exercise program on postoperative outcomes in older patients with low physical fitness scheduled to …
The critical role of Id2 gene in mesenchymal stem cell therapy for colitis through regulating immune response and microbiota
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40450917
Mesenchymal stem cells (MSCs) therapy is a potential treatment strategy for ulcerative colitis (UC). The expression of the Id2 (inhibitor of differentiation factor-2) gene is closely associated with the pathogenesis and prognosis of UC. However, the role of Id2 in the therapeutic efficacy of MSCs for UC remains unclear. In …
18β-Glycyrrhetinic acid from Glycyrrhiza Uralensis protects colonic epithelium in ulcerative colitis by activating Wnt/β-catenin pathway to restore tight junction
Publication Year: 2025 Source: Phytomedicine PMID: 40450977
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon. Glycyrrhiza uralensis extract (ULE), a traditional medicinal plant extract, is globally recognized for its anti-inflammatory and gastrointestinal therapeutic effects. However, the precise mechanisms underlying the therapeutic benefits of ULE in UC management remain …
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