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Protective effect of a novel nonsteroidal organoselenium compound SLL-1-43 on ulcerative colitis through down-regulating NOX2 signaling pathway in vitro and in vivo
Publication Year: 2025 Source: Phytomedicine PMID: 40450981 DOI: 10.1016/j.phymed.2025.156899
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC), is a global health concern characterized by chronic inflammation and oxidative stress. These factors play pivotal roles in its pathogenesis, highlighting the need for novel therapeutic strategies. In this study, we synthesized and screened nine non-steroidal organicselenium compounds to evaluate their …
Primary Prevention of Pouchitis
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40451251
No Abstract
Sex-based differences in the relationship between health-related quality of life, physical activity, and inflammatory markers in people with Crohn's disease
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 40451333
OBJECTIVE: Managing Crohn's disease (CD) requires addressing factors beyond medical treatment alone, including health-related quality of life (HRQoL) and physical activity. This study aimed to understand the relationships between different intensities of physical activity, HRQoL, and inflammatory biomarkers in CD, considering sex as a factor that could influence these associations. …
Polygonati kingianum polysaccharide alleviates dextran sulfate sodium-induced colitis by modulating gut microbiota and metabolic homeostasis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40451347 DOI: 10.1016/j.ijbiomac.2025.144836
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, often associated with dysregulated immune responses, gut barrier dysfunction, and microbial imbalance. In this study, a novel polysaccharide from Polygonatum kingianum (PKP) was extracted and structurally characterized as a mixed-type fructan. Using a dextran sulfate sodium (DSS)-induced …
Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice
Publication Year: 2025 Source: J Adv Res PMID: 40451535
INTRODUCTION: Maternal immune activation (MIA) impairs gut immune function in offspring, with maternal microbiota and their metabolites influencing intestinal development. Indole-3-propionic acid (IPA), a microbial metabolite derived from tryptophan, promotes gut health by enhancing epithelial proliferation. However, the impact of prenatal IPA supplementation on offspring gut outcomes remains unclear. OBJECTIVES: …
Nutrient regulation targeting macrophage-controlled intestinal mucosal healing: A promising strategy against intestinal mucositis induced by deoxynivalenol
Publication Year: 2025 Source: Toxicon PMID: 40451542 DOI: 10.1016/j.toxicon.2025.108434
Deoxynivalenol (DON), one of the most severely polluting mycotoxins globally, contaminates agricultural products and food through environmental pathways, compromising intestinal barrier integrity and homeostasis in humans and animals. This disruption triggers intestinal mucositis and exacerbates inflammatory bowel disease (IBD) progression. Current therapies focusing on immunosuppression face limitations due to drug …
Adiponectin and gastric fundus: A potential target for gut-brain axis dysfunctions
Publication Year: 2025 Source: Physiol Rep PMID: 40452002 DOI: 10.14814/phy2.70398
Adiponectin (ADPN) is a pleiotropic hormone produced by adipose tissue involved in the control of body weight, energy expenditure, and feeding behaviors. Alongside a central effect, ADPN acts on peripheral organs such as the stomach, where it can favor gastric fundus relaxation, reinforcing central satiety signals. Notably, ADPN serum levels …
The functional landscape of the appendix microbiome under conditions of health and disease
Publication Year: 2025 Source: Gut Pathog PMID: 40452061 DOI: 10.1186/s13099-025-00696-2
Traditionally regarded as a vestigial organ, the appendix is now being reevaluated for its significant function in health and nutrition of humans. Serving as a "safe house" for beneficial, desired gut bacteria, the appendix is protected by resilient biofilms that create a secure environment. This makes the appendix a"basin" for …
Impact of immunomodulating medication on maternal Tdap vaccination-induced antibodies in infants
Publication Year: 2025 Source: J Crohns Colitis PMID: 40452230 DOI: 10.1093/ecco-jcc/jjaf090
BACKGROUND AND AIMS: Current international guidelines on inflammatory bowel disease (IBD) advise to continue immunomodulating medication during pregnancy. Data on the effect of this medication on maternal Tdap (Tetanus-Diphtheria-acellular pertussis) vaccination and transfer of antibodies to the infant are scarce. METHODS: Pregnant women with IBD receiving various immunomodulating medications and …
Compounding Prevalence of Inflammatory Bowel Disease in a 2024 Population-Based Study From Canterbury, New Zealand
Publication Year: 2025 Source: JGH Open PMID: 40452912 DOI: 10.1002/jgh3.70192
BACKGROUND AND AIM: The epidemiological patterns of inflammatory bowel disease (IBD) can give insights into disease etiology and health system burden. This study aimed to measure the population-based prevalence in Canterbury and consider the region's position within the 4-stage epidemiological model of IBD. METHODS: Gastroenterology clinics in Canterbury were searched …
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