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The Yield of Colonoscopy in the Evaluation of Constipation: An Age-Based Analysis of Outcome
Publication Year: 2024 Source: J Clin Med PMID: 38792451 DOI: 10.3390/jcm13102910
Background: Chronic constipation, a prevalent gastrointestinal complaint, exhibits rising incidence and diverse clinical implications, especially among the aging population. This study aims to assess colonoscopy performance in chronic constipation across age groups, comprehensively evaluating diagnostic yield and comparing results with average-risk controls. Methods: A retrospective analysis was conducted on 50,578 …
Serum Leucine-Rich α2 Glycoprotein Could Be a Useful Biomarker to Differentiate Patients with Normal Colonic Mucosa from Those with Inflammatory Bowel Disease or Other Forms of Colitis
Publication Year: 2024 Source: J Clin Med PMID: 38792498 DOI: 10.3390/jcm13102957
(1) Background: Serum leucine-rich alpha2 glycoprotein (LRG) has been reported as a useful biomarker for monitoring disease activity in patients with inflammatory bowel disease (IBD). We investigated whether serum LRG can differentiate patients with normal colonic mucosa from those with IBD or other forms of colitis. (2) Methods: Patients with …
Krüppel-like Factor-4-Mediated Macrophage Polarization and Phenotypic Transitions Drive Intestinal Fibrosis in THP-1 Monocyte Models In Vitro
Publication Year: 2024 Source: Medicina (Kaunas) PMID: 38792896 DOI: 10.3390/medicina60050713
Background and Objectives: Despite the fact that biologic drugs have transformed inflammatory bowel disease (IBD) treatment, addressing fibrosis-related strictures remains a research gap. This study explored the roles of cytokines, macrophages, and Kruppel-like factors (KLFs), specifically KLF4, in intestinal fibrosis, as well as the interplay of KLF4 with various gut …
Exploring Electrical Neuromodulation as an Alternative Therapeutic Approach in Inflammatory Bowel Diseases
Publication Year: 2024 Source: Medicina (Kaunas) PMID: 38792911 DOI: 10.3390/medicina60050729
Background and Objectives: This review systematically evaluates the potential of electrical neuromodulation techniques-vagus nerve stimulation (VNS), sacral nerve stimulation (SNS), and tibial nerve stimulation (TNS)-as alternative treatments for inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's Disease (CD). It aims to synthesize current evidence on the efficacy and …
Serum Calprotectin in the Evaluation of Gastrointestinal Diseases: An Ace up Your Sleeve?
Publication Year: 2024 Source: Medicina (Kaunas) PMID: 38792945 DOI: 10.3390/medicina60050762
Background: Calprotectin (CP) is a calcium- and zinc-binding protein that plays a key role in innate immunity and in the recruitment of inflammatory cells. CP can be detected both in serum and in fecal samples. Serum CP (sCP) is more specific for autoimmune diseases, while fecal CP (fCP) has been …
Exploring the Gut Microbiome's Role in Inflammatory Bowel Disease: Insights and Interventions
Publication Year: 2024 Source: J Pers Med PMID: 38793089 DOI: 10.3390/jpm14050507
Inflammatory Bowel Disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition of the intestine that significantly impairs quality of life and imposes a heavy burden on healthcare systems globally. While the exact etiology of IBD is unclear, it is influenced by genetic, …
Diagnostic Utility of Cytomegalovirus (CMV) DNA Quantitation in Ulcerative Colitis
Publication Year: 2024 Source: Viruses PMID: 38793573
No Abstract
Vaccine Acceptance in Patients with Inflammatory Bowel Disease: Lessons Learned from the COVID-19 Pandemic
Publication Year: 2024 Source: Vaccines (Basel) PMID: 38793802 DOI: 10.3390/vaccines12050551
BACKGROUND: Immunomodulating therapies, which are commonly used in patients with Crohn's disease (CD) and ulcerative colitis (UC), have been linked to an increased risk of contracting opportunistic infectious diseases, the majority of which are preventable through vaccination. Nonetheless, vaccination rates in these patients are suboptimal, and frequently lower than in …
Phytosterols and the Digestive System: A Review Study from Insights into Their Potential Health Benefits and Safety
Publication Year: 2024 Source: Pharmaceuticals (Basel) PMID: 38794127 DOI: 10.3390/ph17050557
Phytosterols are a large group of substances belonging to sterols-compounds naturally occurring in the tissues of plants, animals, and humans. The most well-known animal sterol is cholesterol. Among phytosterols, the most significant compounds are beta-sitosterol, stigmasterol, and campesterol. At present, they are mainly employed in functional food products designed to …
Therapeutic Prospects of Mesenchymal Stem Cell and Their Derived Exosomes in the Regulation of the Gut Microbiota in Inflammatory Bowel Disease
Publication Year: 2024 Source: Pharmaceuticals (Basel) PMID: 38794176 DOI: 10.3390/ph17050607
Mesenchymal stem cells (MSCs) have shown great potential in the treatment of several inflammatory diseases due to their immunomodulatory ability, which is mediated by exosomes secreted by MSCs (MSC-Exs). The incidence of inflammatory bowel disease (IBD) is increasing globally, but there is currently no long-term effective treatment. As an emerging …
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