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Mirikizumab Exposure-Response Relationships in Patients with Moderately-to-Severely Active Ulcerative Colitis in Randomized Phase II and III Studies

Publication Year: 2024 Source: Clin Pharmacol Ther PMID: 38797892

No Abstract

'My sexual desires, everything, my normal life just stops'; a qualitative study of male sexual health in inflammatory bowel disease

Publication Year: 2024 Source: J Clin Nurs PMID: 38797921 DOI: 10.1111/jocn.17292

AIM: To describe and interpret the sexual health experiences of men with IBD. DESIGN: Interpretive qualitative study. METHODS: In-depth, semi-structured interviews were conducted with 22 men with a diagnosis of Inflammatory Bowel Disease. Interviews were digitally audio-recorded and transcribed verbatim. Data were analysed using constant comparative, thematic analysis. RESULTS: Three …

Reconstructing parent genomes using siblings and other relatives

Publication Year: 2024 Source: bioRxiv PMID: 38798596 DOI: 10.1101/2024.05.10.593578

Reconstructing the DNA of ancestors from their descendants has the potential to empower phenotypic analyses (including association and genetic nurture studies), improve pedigree reconstruction, and shed light on the ancestral population and phenotypes of ancestors. We developed HAPI-RECAP, a method that reconstructs the DNA of parents from full siblings and …

A Detailed Protocol for the Induction of Anemia and RBC Transfusion-associated Necrotizing Enterocolitis in Neonatal Mice

Publication Year: 2024 Source: Bio Protoc PMID: 38798982

No Abstract

Sirtuin 3 ameliorates inflammatory bowel disease via inhibiting intestinal inflammation and oxidative stress

Publication Year: 2024 Source: J Clin Biochem Nutr PMID: 38799140

No Abstract

MiR-146a alleviates inflammatory bowel disease in mice through systematic regulation of multiple genetic networks

Publication Year: 2024 Source: Front Immunol PMID: 38799464 DOI: 10.3389/fimmu.2024.1366319

INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic disease involving multiple genes, and the current available targeted drugs for IBD only deliver moderate efficacy. Whether there is a single gene that systematically regulates IBD is not yet known. MiR-146a plays a pivotal role in repression of innate immunity, but its …

5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner

Publication Year: 2024 Source: Acta Pharm Sin B PMID: 38799623 DOI: 10.1016/j.apsb.2024.02.020

Aberrant changes in the gut microbiota are implicated in many diseases, including inflammatory bowel disease (IBD). Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity, indicating that microbe-mediated modulation may be a promising strategy for preventing and treating IBD. Although fecal microbiota …

Pollutants, microbiota and immune system: frenemies within the gut

Publication Year: 2024 Source: Front Public Health PMID: 38799688

No Abstract

Vedolizumab Safety During Pregnancy and Lactation in a Patient with Ulcerative Colitis: A Case Report

Publication Year: 2024 Source: Clin Exp Gastroenterol PMID: 38799766 DOI: 10.2147/CEG.S457256

BACKGROUND: Inflammatory bowel disease (IBD) affects young adults of reproductive age, and questions related to pregnancy and breastfeeding are common in clinical practice. Most medications used to treat IBD are considered safe during pregnancy, except methotrexate and small molecules such as tofacitinib. Despite few studies regarding vedolizumab (VDZ) safety, it …

Testing and Diagnosis of Clostridioides difficile Infection in Special Scenarios: A Systematic Review

Publication Year: 2024 Source: Cureus PMID: 38800338

No Abstract

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