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Alleviation of dextran sulfate sodium (DSS)-induced colitis in mice through the antioxidative effects of muscone via the MyD88/p38 MAPK signalling pathway
Publication Year: 2025 Source: PeerJ PMID: 40452925 DOI: 10.7717/peerj.19397
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by chronic inflammation. Ulcerative colitis (UC) is a subtype of IBD. The symptoms of UC include inflammation, damage to crypts, and ulceration. UC patients frequently experience comorbid psychological disorders. Muscone has notable anti-inflammatory, antioxidative, and antidementia properties. Our study aimed to investigate the …
Unveiling the role of gasdermin B in cancer and inflammatory disease: from molecular mechanisms to therapeutic strategies
Publication Year: 2025 Source: PeerJ PMID: 40452932
Gasdermin B (GSDMB) is a member of the gasdermin (GSDM) protein family, primarily known for mediating pyroptosis, an inflammatory form of programmed cell death. Recent studies have revealed the diverse molecular functions of GSDMB and its close association with various diseases, particularly cancers (e.g., breast cancer, gastric cancer, bladder cancer) …
Editorial: The role of inflammation and immune control in digestive disease and therapeutic approaches
Publication Year: 2025 Source: Front Immunol PMID: 40453090
No Abstract
Demographic and Phenotypic Distribution of Inflammatory Bowel Disease in 1015 Patients Attending a Quaternary Care Center in Nepal
Publication Year: 2025 Source: Cureus PMID: 40453256 DOI: 10.7759/cureus.83226
Objective Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), has been seen as an emerging health problem in Nepal with urbanization and the adoption of a Western lifestyle. Our study aimed to determine the various demographic and phenotypic features of IBD in Nepal. Methods This prospective …
Perianal panniculitis presenting as chronic perianal pain: a diagnostic challenge
Publication Year: 2025 Source: J Surg Case Rep PMID: 40453744
Perianal panniculitis is a rare inflammatory condition characterized by painful, tender, and swollen lesions in the perianal region. It can mimic other conditions such as abscesses, fistulas, malignancies, or inflammatory bowel disease. This case reflects on the rarity of Perianal panniculitis and its varied presentations and the importance of considering …
Correction: Mechanism underlying the role of the circRNA OMA1/miR-654-3p/RAF1 axis in children with inflammatory bowel disease
Publication Year: 2025 Source: Cytotechnology PMID: 40453924
[This corrects the article DOI: 10.1007/s10616-025-00703-z.].
Characterization of immunosuppression of genotype A2dB1 variant infectious bursal disease virus isolated in Malaysia using specific pathogen-free and commercial broiler chickens
Publication Year: 2025 Source: Vet World PMID: 40453937 DOI: 10.14202/vetworld.2025.799-807
BACKGROUND AND AIM: Infectious bursal disease (IBD) is an immunosuppressive disease caused by the IBD virus (IBDV), which adversely affects poultry vaccination programs. The novel variant IBDV (nvIBDV) has recently emerged in various regions, including Malaysia, raising concerns about its immunosuppressive potential and impact on Newcastle disease (ND) vaccination. This …
Diet's impact on gut microbial assemblage in health and disease
Publication Year: 2025 Source: J Clin Invest PMID: 40454482
The gut microbiome has been linked to everything from human behavior to athletic performance to disease pathogenesis. And yet, few universal truths have emerged regarding how the microbiome exerts its effects or responds to the host environment except for one: gut microbiota are exquisitely sensitive to human diets. What we …
Genome-wide Association Studies of the Pathogenic Sphingosine-1-Phosphate Gene in Ulcerative Colitis
Publication Year: 2025 Source: Endocr Metab Immune Disord Drug Targets PMID: 40454507
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that can lead to malignancies over time. Sphingosine-1-phosphate (S1P) receptor signaling affects lymphocyte trafficking and vascular integrity, influencing intestinal inflammation. This study aimed to identify S1P-related key genes in UC. METHODS: Differentially expressed genes (DEGs) between the UC and control …
Chitosan-Supported Molecularly Imprinted Polypyrrole@MoSe(2) Nanosheet-Based Bioinspired Electrochemical Sensor for Improved Quantification of Gut Microbiota-Derived Hippuric Acid
Publication Year: 2025 Source: ACS Appl Bio Mater PMID: 40454614
Hippuric acid (HA) is a well-known gut microbiota-derived metabolite involved in the development of various diseases such as chronic kidney disease, Chron's disease, and inflammatory bowel disease. HA being one of the most commonly found metabolites in gut microbiota is an important analyte considered for establishing an efficient, quick, sensitive, …
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