Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Outcomes of intended temporary stomas in Crohn's disease (INTESTINE study): international, multicentre, retrospective study
Publication Year: 2025 Source: BJS Open PMID: 40454941
BACKGROUND: Patients with ileocolic Crohn's disease often require surgery that can result in temporary stoma formation. Stomas are associated with a morbidity and can negatively impact quality of life. This study aimed to investigate the short-term (6-month) and mid-term (18-month) outcomes of intended temporary stomas in patients with Crohn's disease. …
IL-17A inhibitor-induced ulcerative colitis treated with an anti-IL-23 antibody
Publication Year: 2025 Source: Clin J Gastroenterol PMID: 40455166
Interleukin-17 (IL-17) has been suggested to have a protective effect on the intestinal mucosa. The administration of an anti-IL-17 receptor monoclonal antibody has been associated with the onset of inflammatory bowel disease. We present a case of ulcerative colitis caused by secukinumab, an anti-IL-17 receptor A monoclonal antibody, that was …
Gastrointestinal Manifestations of Common Variable Immunodeficiency: A Mentored Review
Publication Year: 2025 Source: Dig Dis Sci PMID: 40455348
BACKGROUND: Common variable immunodeficiency (CVID) is an umbrella term for numerous primary immunodeficiency syndromes characterized by B-cell, and sometimes T-cell, impairment. While CVID is commonly associated with recurrent sinopulmonary infections, gastrointestinal (GI) disease-often presenting atypically due to immune dysregulation-can significantly the increase morbidity and mortality of those affected. OBJECTIVES: This …
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Publication Year: 2025 Source: J Vis Exp PMID: 40455679 DOI: 10.3791/68034
Ulcerative colitis (UC) is a globally prevalent and refractory disease that imposes a substantial socioeconomic burden, with no universally effective treatment currently available. Traditional Chinese medicine (TCM) demonstrated promising therapeutic potential in UC management, particularly through the application of Chinese herbal retention enema, which is gaining increasing international recognition. This …
Cancer incidence in patients with ulcerative colitis naïve to or treated with thiopurine and targeted therapies-a cohort study 2007 to 2022 with comparison to the general population
Publication Year: 2025 Source: J Crohns Colitis PMID: 40455688
BACKGROUND: Cancer incidence data including absolute risk differences are needed for clinical risk communication to patients receiving modern-day treatments for ulcerative colitis (UC). METHODS: We linked nationwide Swedish health registers and assessed incident cancers in patients with UC in 2007-2022. We computed age-stratified incidence rates (IRs), IR differences, and hazard …
Safety and efficacy of the anti-TL1A monoclonal antibody tulisokibart for Crohn's disease: a phase 2a induction trial
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 40456235
BACKGROUND: TNF-like cytokine 1A (TL1A) is a key mediator of inflammation and fibrosis. The efficacy and safety of the anti-TL1A monoclonal antibody tulisokibart as induction treatment was assessed in adults with moderately to severely active Crohn's disease with a history of insufficient response, loss of response, or intolerance to conventional …
Piperine Improves DSS-Induced Colitis in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota
Publication Year: 2025 Source: Phytother Res PMID: 40456559 DOI: 10.1002/ptr.8491
Inflammatory bowel disease (IBD) is a global health concern with limited therapeutic options. Previous studies have demonstrated that piperine exhibited anti-inflammatory effects both in vitro and in vivo. However, its potential to ameliorate colitis in mice through modulation of gut microbiota has not been explored. This study aimed to investigate …
Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD
Publication Year: 2025 Source: Nat Commun PMID: 40456745 DOI: 10.1038/s41467-025-60233-2
Inflammatory bowel diseases (IBDs) are chronic disorders involving dysregulated immune responses. Despite the role of disrupted host-microbial interaction in the pathophysiology of IBD, the underlying metabolic principles are not fully understood. We densely profiled microbiome, transcriptome and metabolome signatures from longitudinal IBD cohorts before and after advanced drug therapy initiation …
Prioritizing inflammatory bowel disease
Publication Year: 2025 Source: Nat Rev Gastroenterol Hepatol PMID: 40457014
No Abstract
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch
Publication Year: 2025 Source: Nat Immunol PMID: 40457062 DOI: 10.1038/s41590-025-02166-y
Succinate levels are increased in inflammatory bowel disease (IBD), but its role in disease pathogenicity remains unknown. Here we showed that succinate promoted colitis in mice by reducing the expression of FOXP3 and increasing the expression of interleukin-17 in regulatory T (T(reg)) cells. Succinate selectively reduced the expression of 2-oxoglutarate …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide