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Disclosing Inflammatory Bowel Disease: A Systematic Review and Meta-Synthesis Exploring the Experience of, and Barriers and Facilitators to, Self-Disclosure
Publication Year: 2025 Source: J Clin Psychol Med Settings PMID: 40457133 DOI: 10.1007/s10880-025-10079-z
Due to its invisible nature, individuals must make decisions around self-disclosing Inflammatory Bowel Disease (IBD). Existing reviews have explored stigma as a barrier to disclosing IBD; however, other factors potentially affecting disclosure decisions have not been recently reviewed. The current review sought to synthesise qualitative papers exploring the experiences of …
Global, regional, and national burden of inflammatory bowel disease in persons aged 60-89 years from 1992 to 2021
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40457222 DOI: 10.1186/s12876-025-04042-3
BACKGROUND: The global burden of inflammatory bowel disease (IBD) is increasing, but detailed data on older adults remain scarce. OBJECTIVE: This study describes trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of IBD among individuals aged 60-89 years from 1992 to 2021 at global, regional, and national levels, …
MDA5 variants trade antiviral activity for protection from autoimmune disease
Publication Year: 2025 Source: BMC Med Genomics PMID: 40457382 DOI: 10.1186/s12920-025-02171-y
Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studies (GWAS). MDA5 loss-of-function variants have also been reported to increase the risk of inflammatory bowel disease (IBD). Whether these associations are linked …
Exploring the genetic basis between inflammatory bowel disease and venous thromboembolism
Publication Year: 2025 Source: Thromb J PMID: 40457427 DOI: 10.1186/s12959-025-00745-5
BACKGROUND: The elevated prevalence of venous thromboembolism (VTE) among individuals diagnosed with inflammatory bowel disease (IBD) necessitates thorough investigation. Analyzing the genetic association mechanisms between these conditions is essential for comprehending their concurrent manifestation. METHODS: Using genome-wide association study (GWAS) datasets for IBD and VTE, we applied a comprehensive approach …
Correction to "Oral Administration of Bioactive Nanoparticulates for Inflammatory Bowel Disease Therapy by Mitigating Oxidative Stress and Restoring Intestinal Microbiota Homeostasis"
Publication Year: 2025 Source: Mol Pharm PMID: 40457573
No Abstract
Long-term disease course of ulcerative colitis in a prospective European population-based inception cohort-an Epi-IBD cohort study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40457747 DOI: 10.1093/ecco-jcc/jjaf089
BACKGROUND AND AIMS: The Epi-IBD cohort is a population-based inception cohort of patients with inflammatory bowel disease from 22 European centers. The aim was to assess the 10-year disease course of patients with ulcerative colitis (UC) across Europe. METHODS: Patients were followed prospectively from the time of diagnosis in 2010 …
Efficacy and safety probiotics as adjuvant treatment for Crohn's disease: a meta-analysis of randomized controlled trials
Publication Year: 2025 Source: Curr Res Food Sci PMID: 40458119
Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by periods of remission and relapse. Probiotics have been suggested as potential therapeutic agents for managing CD, but their effects on clinical outcomes remain unclear. This meta-analysis aimed to evaluate the efficacy and safety of probiotics in patients with CD. …
Bile acid-mediated gut-liver axis crosstalk: the role of nuclear receptor signaling in dynamic regulation of inflammatory networks
Publication Year: 2025 Source: Front Immunol PMID: 40458398 DOI: 10.3389/fimmu.2025.1595486
Bile acids (BAs) are critical mediators of metabolic and immune regulation, influencing both liver and intestinal function. Their homeostasis, maintained through the enterohepatic circulation, is pivotal for immune-metabolic balance. BAs activate key receptors, including Farnesoid X Receptor (FXR) and TGR5, to modulate inflammation. FXR exerts anti-inflammatory effects by suppressing NF-kappaB …
Technical note: Reducing dextran sodium sulfate (DSS) interference with gene-expression quantification in a mouse model of colitis
Publication Year: 2025 Source: J Anim Sci PMID: 40458848
Gene expression analysis via reverse transcription quantitative real-time polymerase chain reaction (qPCR) can be inhibited by various substances, including dextran sodium sulfate (DSS), a chemical commonly used to induce intestinal inflammation in animal models. Ensuring elimination and reduction of qPCR interference in tissues from laboratory animals following oral administration of …
The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis
Publication Year: 2025 Source: Biosci Rep PMID: 40459411 DOI: 10.1042/BSR20253205
Inflammatory bowel disease (IBD) is a gastrointestinal disorder characterised by elevated colonic neutrophil extracellular traps (NETs), which are associated with disease severity. Formation of NETs is primarily driven by peptidyl arginine deaminase IV (PAD4) and other enzymes including myeloperoxidase (MPO) and neutrophil elastase. The present study evaluated the effect of …
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