Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction
Publication Year: 2025 Source: Mol Cell PMID: 40614706
Necroptosis is a pro-inflammatory, lytic cell death executed by a pseudokinase mixed lineage kinase-like protein MLKL. Upon necroptosis induction by various inflammatory signals, MLKL is phosphorylated by receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and translocates from the cytosol to the plasma membrane, causing membrane disruption and the release of damage-associated molecular …
Development and validation of peripheral blood DNA methylation signatures to predict response to biological therapy in adults with Crohn's disease (EPIC-CD): an epigenome-wide association study
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 40614748
BACKGROUND: Biological therapeutics are widely used in Crohn's disease, with evidence of efficacy from randomised trials and real-world experience. Primary non-response is a common, poorly understood problem. We aimed to assess blood methylation as a predictor of response to adalimumab, vedolizumab, or ustekinumab in patients with Crohn's disease. METHODS: This …
Aptamer-chitosan modified chlorogenic acid derived nanoparticles for enhancing target treatment in diarrhea-predominant irritable bowel syndrome
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40615011
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common chronic non-organic gastrointestinal disorder often associated with low-grade intestinal inflammation that disrupts gut function. However, current therapies remain inadequate for achieving sustained symptom relief. In this study, chlorogenic acid-derived carbon nanoparticles (CHA CNs), synthesized via a hydrothermal method, were further encapsulated within …
Dietary Patterns and Incident Chronic Constipation in Three Prospective Cohorts of Middle- and Older-aged Adults
Publication Year: 2025 Source: Gastroenterology PMID: 40615053
BACKGROUND AND AIMS: Current literature on diet-constipation associations is limited by small sample sizes and cross-sectional designs. We aimed to comprehensively examine the associations between five dietary patterns, their components, and incident constipation. METHODS: In three large cohorts, the Nurses' Health Study (NHS), NHSII, and the Health Professional Follow-up Study …
Mendelian randomization analysis reveals causal associations between autoimmune diseases and female infertility risk
Publication Year: 2025 Source: Reprod Toxicol PMID: 40615097
BACKGROUND: Infertility is viewed as a significant social challenge globally. Numerous observational studies have documented the link between autoimmune diseases (ADs) and female infertility, yet the underlying cause remained unclear. The primary objective of this study was to ascertain the causal connection between ADs and female infertility. METHOD: We evaluated …
Evaluation of a virtual reality-directed brain-gut behavioural treatment inpatient program for patients with inflammatory bowel disease: protocol for a pilot feasibility trial
Publication Year: 2025 Source: BMJ Open PMID: 40615149
INTRODUCTION: Pain is one of the most bothersome symptoms that affects patients with inflammatory bowel disease (IBD) but is often inadequately treated. Inadequate pain control in the inpatient setting not only impacts patients' experience but increases opioid use and hospital length of stay. Opioids are often considered first-line treatment for …
NAT10-mediated acetylation of NIK mRNA in B cells promotes IgA production
Publication Year: 2025 Source: EMBO Rep PMID: 40615576
The regulation of IgA expression is crucial for maintaining mucosal immune homeostasis, providing a vital defense mechanism against pathogens at mucosal surfaces. However, the intricate mechanisms governing IgA class-switch recombination and its dysregulation in diseases such as inflammatory bowel disease remain a significant challenge in the field. Our study delves …
Oral Microcapsule Chromocolonoscopy With Patent Blue V Improves Adenoma Detection Safely and Effectively
Publication Year: 2025 Source: United European Gastroenterol J PMID: 40616371
BACKGROUND AND OBJECTIVE: Chromocolonoscopy significantly improves polyp/adenoma detection rates (PDR/ADR). However, its integration into routine clinical practice is hindered by its cumbersome mode of application. The objective was to develop an oral nutritional grade delivery system and to assess its efficacy for colonic release, mucosal staining and PDR/ADR as a …
Psoas muscle CT radiomics-based machine learning models to predict response to infliximab in patients with Crohn's disease
Publication Year: 2025 Source: Ann Med PMID: 40616584
BACKGROUND: Crohn's disease (CD) is a chronic inflammatory bowel disease, with infliximab (IFX) commonly used for treatment. However, no clinically applicable model currently exists to predict the response of patients with CD to IFX therapy. Given the strong association between sarcopenia and IFX treatment outcomes, this study developed computerized tomography …
FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in inflammatory bowel disease-induced bone loss
Publication Year: 2025 Source: Cell Rep PMID: 40616843
The gut-bone axis is critical for body homeostasis, but bone loss often complicates inflammatory bowel disease (IBD) with unclear mechanisms. Here, we found that IBD mice showed reduced bone formation, with bone marrow mesenchymal stromal cells (BMSCs) favoring adipogenesis over osteogenesis. Altered N(6)-methyladenosine (m(6)A) modifications of BMSCs were confirmed in …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide