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Gut feeling: understanding the endometriosis-digestive link to enhance patient care and symptom control
Publication Year: 2025 Source: Curr Opin Obstet Gynecol PMID: 40459422
PURPOSE OF REVIEW: Endometriosis is a chronic inflammatory condition that frequently presents with gastrointestinal (GI) symptoms that overlap with disorders such as irritable bowel syndrome, inflammatory bowel disease, and gastroparesis, leading to diagnostic delays. Recent research highlights the intricate relationship between endometriosis and gut health, including the role of microbiota, …
CRAC channels and patho-physiology of peripheral organ systems
Publication Year: 2025 Source: Biochem Soc Trans PMID: 40459545
A rise in cytosolic Ca2+ is used as a key signalling messenger in eukaryotic cells. The Ca2+ signal drives life and death and controls myriad responses in between. Inherent in the use of such a multifarious signal is the danger of disease, arising from dysregulated Ca2+ signalling. One ancient, highly …
Three-Dimensional-Printed Models and Shared Decision-Making: A Cluster Randomized Clinical Trial
Publication Year: 2025 Source: JAMA Netw Open PMID: 40459895
IMPORTANCE: Patients undergoing surgery report a lack of involvement in health care decisions and increased anxiety. Three-dimensional (3D)-printed models serve as educational tools to encourage patient engagement, reduce anxiety levels, and aid understanding. OBJECTIVE: To determine the impact of 3D-printed anatomic models on shared decision-making (SDM) and patient anxiety during …
Safety of biologic therapy in kidney and liver transplant recipients with systemic inflammatory diseases: a real-world study from Israel
Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 40459901
OBJECTIVES: Safety is a concern for solid-organ transplant (SOT) recipients with systemic inflammatory diseases (SID) treated with biologic therapy. This study evaluated the safety of biologic therapy in SOT recipients with SID. METHODS: This retrospective study between 2000-2024 included 20 biologic-treated SOT recipients with SID matched to 56 SOT recipients …
Breastfeeding and Health Outcomes for Infants and Children
Publication Year: 2025 Source: Breastfeeding and Health Outcomes for Infants and Children PMID: 40460216
OBJECTIVES: To review the evidence on the association between breastfeeding and infant and child health outcomes, including the extent to which these associations vary by the intensity, duration, mode, and source of breastmilk consumption. In this review, breastfeeding refers to feeding breastmilk whether directly from the breast or other means …
Elevated CXCL1 expression contributes to the development of pediatric Crohn's disease and serves as a diagnostic marker: A reanalysis based on the integrative bioinformatics
Publication Year: 2025 Source: Cytokine PMID: 40460502
PURPOSE: Pediatric Crohn's disease (PCD), which is a severe illness impacting the physical health of children. Nevertheless, there is still a lack of highly efficient diagnostic markers. Here, we aim to develop efficient diagnostic and treatment approaches, gaining a deeper understanding of the molecular mechanisms and potential targets causing PCD. …
Forensic SNP genealogy inference using whole genome sequencing data of varying depths
Publication Year: 2025 Source: Forensic Sci Int Genet PMID: 40460754 DOI: 10.1016/j.fsigen.2025.103296
High-density single nucleotide polymorphism (SNP) genotyping data at varying depths were obtained through whole genome sequencing (WGS). The accuracy of genotyping was evaluated, and methods for forensic SNP genealogy inference using WGS data were explored. The impact of sequencing depth on the accuracy of forensic genealogy inference was also assessed. …
Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis
Publication Year: 2025 Source: Med PMID: 40460824
BACKGROUND: Fecal microbiota transplantation (FMT) is an emerging treatment for ulcerative colitis (UC), but the impact of prebiotic fiber on FMT efficacy for UC is unclear. We performed a randomized, double-blind, placebo-controlled clinical trial to examine the efficacy of FMT with and without dietary fiber supplementation in patients with UC. …
Rosacea and Its Potential Role in the Development of Irritable Bowel Syndrome: Insights From the Korean National Health Insurance Service-National Sample Cohort
Publication Year: 2025 Source: J Korean Med Sci PMID: 40461142
BACKGROUND: Rosacea is a chronic inflammatory skin disease. Recent studies have indicated its impacts on systemic health beyond dermatological symptoms. The gut-skin axis theory, which explores the interaction between gastrointestinal and skin health, may explain the influence of rosacea on gastrointestinal disorders. This study investigates the potential link between rosacea …
[Pathogenesis and treatment of "inflammation cancer transformation" of ulcerative colitis based on "Kenang" theory]
Publication Year: 2025 Source: Zhongguo Zhong Yao Za Zhi PMID: 40461238
Ulcerative colitis(UC) is a recurrent, chronic, nonspecific inflammatory bowel disease. The longer the course of the disease, the higher the risk of cancerization. In recent years, the incidence and mortality rates of colon cancer in China have been increasing year by year, seriously threatening the life and health of patients. …
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