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TSP50 deficiency in neural stem cells aggravates colitis in mice by altering intestinal microbiome
Publication Year: 2025 Source: NPJ Biofilms Microbiomes PMID: 40461483 DOI: 10.1038/s41522-025-00737-3
Inflammatory bowel disease (IBD) is a complex disease characterized by persistent chronic inflammation of the gastrointestinal tract and periodic episodes. Despite the increasing number of related studies, the detailed pathogenesis of IBD has not been elucidated. In recent years, host-microbiota interactions in the pathogenesis of IBD have received extensive attention. …
Oral-gut axis in inflammation: periodontitis exacerbates ulcerative colitis via microbial dysbiosis and barrier disruption
Publication Year: 2025 Source: BMC Oral Health PMID: 40462053
BACKGROUND: Periodontitis is a chronic inflammatory disease, having significant impact on systemic conditions. Ulcerative colitis (UC) is a chronic relapsing inflammatory disorder of the intestines. Studies have suggested a potential association between periodontitis and UC. This study aims to elucidate the influence of periodontitis on the progression of UC and …
From gut inflammation to psychiatric comorbidity: mechanisms and therapies for anxiety and depression in inflammatory bowel disease
Publication Year: 2025 Source: J Neuroinflammation PMID: 40462068 DOI: 10.1186/s12974-025-03476-6
No Abstract
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms
Publication Year: 2025 Source: Cell Commun Signal PMID: 40462136 DOI: 10.1186/s12964-025-02264-2
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by epithelial barrier dysfunction, where in the cytoskeleton, especially actin microfilaments and intermediate filaments, has been extensively investigated for its critical role in maintaining the structural integrity of the epithelial barrier. However, the specific contribution of microtubules to this process remains unknown. METHODS: …
The duration of prior anti-tumor necrosis factor agents is associated with the effectiveness of vedolizumab in patients with ulcerative colitis: a real-world multicenter retrospective study
Publication Year: 2025 Source: Intest Res PMID: 40462299 DOI: 10.5217/ir.2024.00126
BACKGROUND/AIMS: Previous literature suggests that the response of patients with ulcerative colitis to vedolizumab may be affected by previous biologic therapy exposure. This real-world study evaluated vedolizumab treatment effectiveness in biologicnon- naive patients. METHODS: This was a multicenter, retrospective, observational chart review of records from 16 hospitals in Japan (December …
Inflammatory Bowel Disease and Risk of Rheumatoid Arthritis: A UK Biobank Cohort Study
Publication Year: 2025 Source: Int J Rheum Dis PMID: 40462314 DOI: 10.1111/1756-185X.70314
OBJECTIVES: Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are both prevalent inflammatory conditions within the population. Our objective was to explore the relationship between IBD and RA, while examining the role of inflammatory mediators in the observed association. METHODS: We used data from the UK Biobank, a population-based prospective …
Untwisting the plot: Resolving a misdiagnosis of Crohn's disease in an ulcerative colitis patient with a twisted J-pouch-A video vignette
Publication Year: 2025 Source: Colorectal Dis PMID: 40462349
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are two primary forms of inflammatory bowel disease, both characterized by chronic, relapsing inflammation of the gastrointestinal tract. Clinicians differentiate between CD and UC using a combination of clinical, endoscopic and histological findings. However, there are instances where the initial pathology is …
Potential therapeutic effects of ibudilast and retinoic acid against cuprizone-induced behavioral and biochemical changes in mouse brain
Publication Year: 2025 Source: Front Mol Neurosci PMID: 40462835 DOI: 10.3389/fnmol.2025.1567226
Ibudilast (IBD) is a new drug that has been released as treatment for multiple sclerosis (MS). Retinoic acid (RA), a metabolite of vitamin A, is known for its pro-regenerative and anti-inflammatory properties, therefore, it has been suggested as a supplementary treatment for MS. The objective of this study is to …
High-Throughput Human Gut Immune Co-Culture Model for Evaluating Inflammatory Bowel Disease Anti-Inflammatory Therapies
Publication Year: 2025 Source: bioRxiv PMID: 40462955 DOI: 10.1101/2025.05.14.654072
Current treatments for inflammatory bowel disease (IBD) are often ineffective long-term, as many patients ultimately become unresponsive to anti-inflammatory drugs. The need for improved therapeutics is urgent. Animal models utilized for drug development are limited by interspecies variability and poor translatability. However, most in vitro models lack the sophistication to …
Regulation of Epithelial HIF by Probiotic Escherichia coli
Publication Year: 2025 Source: bioRxiv PMID: 40463037 DOI: 10.1101/2025.05.14.654147
The gastrointestinal tract is home to trillions of microorganisms that interact with their host in profound ways, including regulation of immune, endocrine, and neurological functions. One mechanism by which these microbes interact with their eukaryotic host is through the generation of short-chain fatty acids (SCFAs), which are metabolized by the …
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