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Cascade Magnetic Hyperthermia Therapy for Biofilm Eradication and Bone Regeneration via Dual Osteoimmuno-regulation
Publication Year: 2025 Source: ACS Nano PMID: 40465864 DOI: 10.1021/acsnano.5c04595
Infected bone defects (IBDs) treatment presents a great challenge in current orthopedics due to the complex nature of these defects, and the diversified demands involving infection control and subsequent bone regeneration. Current-available treatments often fail to address these multifaceted needs effectively. Herein, we propose a cascade magnetic hyperthermia therapy (cMHT) …
Illuminating prospects of probiotic Akkermansia muciniphila in intestinal inflammation and carcinogenesis
Publication Year: 2025 Source: Microbiol Res PMID: 40466419
Akkermansia muciniphila (A. muciniphila) is portrayed as an advantageous enteric bacterium with a particular property of mucin utilization. Emerging data suggest A. muciniphila can reshape gut chronic inflammation, enhance intestinal epithelial tight junctions, and sensitize toll-like receptors 2 (TLR2) and TLR4 to restrain the infiltrating cytotoxic T lymphocytes and macrophages. …
Influencing factors on detection rate of granuloma in Crohn's disease: A retrospective analysis
Publication Year: 2025 Source: Pathol Res Pract PMID: 40466578
BACKGROUND: The detection of non-caseating granulomas in histopathological analysis is a key criterion for Crohn's disease (CD) diagnosis. The low frequency of granuloma identification poses a significant challenge to early and accurate diagnosis. This study aims to identify factors affecting granuloma detection rate in CD patients, as well as assess …
Buzhongyiqi granules in ulcerative colitis Therapy: Integrated chemical composition, pharmacodynamic validation, and IL-6/STAT3 axis regulation
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40466879
ETHNOPHARMACOLOGICAL RELEVANCE: Buzhongyiqi Granules (BZYQ), a classical herbal formulation derived from Pi Wei Lun, is traditionally used to regulate Qi and blood circulation while enhancing immune function, particularly for gastrointestinal disorders. However, its protective effects and mechanisms on ulcerative colitis (UC) remain unclear. AIM OF THE STUDY: This study aimed …
An Often-Forgotten Complication of Upadacitinib
Publication Year: 2025 Source: Gastroenterology PMID: 40466975
No Abstract
DUOX2-mediated gut barrier dysfunction: a preclinical mechanism in IBD pathogenesis?
Publication Year: 2025 Source: Gut PMID: 40467103 DOI: 10.1136/gutjnl-2025-335565
No Abstract
Dehydrodiisoeugenol targets NOD2 exerting dual effects against colitis and colorectal cancer: a double-edged sword
Publication Year: 2025 Source: Mol Med PMID: 40468178
Dehydrodiisoeugenol (DEH) is a primary benzofuran-type neolignan isolated from the Chinese herbal medicine nutmeg, which is used in the treatment of gastrointestinal diseases. This study aims to observe the dual therapeutic effects of DEH on DSS-induced ulcerative colitis (UC) and colorectal cancer (CRC), with a focus on exploring the molecular …
Predictive accuracy of fecal calprotectin in assessing clinical activity and disease severity in patients with Ulcerative Colitis and Crohn's disease
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40468181 DOI: 10.1186/s12876-025-04035-2
BACKGROUND: Inflammatory bowel disease (IBD) is an idiopathic disorder characterized by repeated relapses and remissions. Endoscopy, the gold standard for diagnosis and monitoring of these patients is time consuming, expensive, and invasive. Hence, faecal calprotectin (FCP) has been suggested as marker to determine the degree of intestinal inflammation and predict …
Association of Vitiligo With Autoimmune Disorders: A Bidirectional Two-Sample and Summary-Based Mendelian Randomization Study
Publication Year: 2025 Source: J Cosmet Dermatol PMID: 40468464
No Abstract
Lack of Efficacy of Concomitant 5-Aminosalicylic Acid With Vedolizumab in Inflammatory Bowel Disease: A Large-Scale Administrative Database Analysis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40468574
No Abstract
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