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Immunogenicity and Efficacy of Subcutaneous Infliximab Monotherapy vs Combination Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40378993 DOI: 10.1016/j.cgh.2025.03.021
BACKGROUND & AIMS: Intravenous (IV) infliximab (IFX) combined with an immunomodulator (combination therapy) outperforms IV IFX monotherapy in terms of clinical, endoscopic, and immunogenicity outcomes in patients with inflammatory bowel disease (IBD). With the advent of subcutaneous (SC) IFX, which is associated with higher serum drug concentrations, it is essential …
Unraveling the Association between Apical Periodontitis and Inflammatory Bowel Disease Through Mendelian Randomization
Publication Year: 2025 Source: J Endod PMID: 40379237
INTRODUCTION: The objective of this investigation was to assess the genetic predispositions linking apical periodontitis to inflammatory bowel disease (encompassing ulcerative colitis [UC] and Crohn's disease [CD]). METHODS: Single nucleotide polymorphisms were used as instrumental variables, and the radial inverse-variance weighted method was utilized as the primary analytical approach. Steiger …
Author's reply: "Comment on "Italian validation of the IBD-disk tool for the assessment of disability in inflammatory bowel diseases""
Publication Year: 2025 Source: Dig Liver Dis PMID: 40379540 DOI: 10.1016/j.dld.2025.04.039
No Abstract
Factors associated with response to filgotinib and the prognostic power of faecal calprotectin for ulcerative colitis in the phase 2b/3 SELECTION trial
Publication Year: 2025 Source: Dig Liver Dis PMID: 40379541 DOI: 10.1016/j.dld.2025.04.036
BACKGROUND: Patients with moderately to severely active ulcerative colitis have distinct filgotinib response trajectories. AIMS: Evaluate factors associated with response to filgotinib over time. METHODS: Patients from SELECTION (NCT02914522) receiving filgotinib 200 mg (FIL200) or 100 mg (FIL100), or placebo were included. Factors associated with partial Mayo Clinic Score (pMCS) …
Diet-pathobiont interplay in health and inflammatory bowel disease
Publication Year: 2025 Source: Trends Microbiol PMID: 40379577 DOI: 10.1016/j.tim.2025.04.003
The intestinal microbiota plays a crucial role in maintaining host health by participating in various beneficial functions. However, under certain conditions, it can contribute to the development of inflammatory bowel disease (IBD) and other chronic inflammatory conditions. Importantly, not all commensal microbiota members are drivers of inflammation. A specific subset …
Weighing the Consequences: Can Patients with Inflammatory Bowel Disease Jump on the GLP-1 Bandwagon?
Publication Year: 2025 Source: Dig Dis Sci PMID: 40380015 DOI: 10.1007/s10620-025-09088-7
No Abstract
Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles in gastric cancer, colorectal cancer, and inflammatory bowel disease
Publication Year: 2025 Source: J Transl Med PMID: 40380167 DOI: 10.1186/s12967-025-06552-w
INTRODUCTION: Gastrointestinal disorders (GIDs) affect nearly 40% of the global population, with gut microbiome-metabolome interactions playing a crucial role in gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD). This study aims to investigate how microbial and metabolic alterations contribute to disease development and assess whether biomarkers identified …
Engineering the Future of Regenerative Medicines in Gut Health with Stem Cell-Derived Intestinal Organoids
Publication Year: 2025 Source: Stem Cell Rev Rep PMID: 40380985 DOI: 10.1007/s12015-025-10893-w
The advent of intestinal organoids, three-dimensional structures derived from stem cells, has significantly advanced the field of biology by providing robust in vitro models that closely mimic the architecture and functionality of the human intestine. These organoids, generated from induced pluripotent stem cells (iPSCs), embryonic stem cells (ESCs), or adult …
Evaluation of retinal and choroidal structures in patients with ulcerative colitis
Publication Year: 2025 Source: Int Ophthalmol PMID: 40381120
PURPOSE: To evaluate the macula, peripapillary retinal nerve fiber layer (RNFL) thickness, retinal layers, and choroidal vascularity index (CVI) in patients with ulcerative colitis (UC). METHODS: A total of 92 patients were included in this study, with 40 in the UC group and 52 in the control group. RNFL, retinal …
Calprotectin inhibition attenuates silica-induced lung fibrosis
Publication Year: 2025 Source: Inflammopharmacology PMID: 40381145
Respirable silica exposure adversely affects lung tissue immunopathology, triggering oxidative bursts in macrophages and neutrophils, releasing Damage-associated molecular patterns (DAMPs), including calprotectin proteins, S100A8, and S100A9. Calprotectin constitutes up to 45% of these innate immune cells, and serum levels of these alarmins correlate with inflammation, fibrosis, remodelling, and drug response …
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