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Gut microbiota as a mediator of cancer development and management: From colitis to colitis-associated dysplasia and carcinoma
Publication Year: 2025 Source: Biochim Biophys Acta Rev Cancer PMID: 40617308
Colitis-associated colorectal cancer (CAC) develops as a result of prolonged colitis in patients with inflammatory bowel disease. In recent years, the role of the gut microbiota in colitis-associated colorectal carcinogenesis has begun to be recognized. Specific microbes, such as enterotoxigenic Bacteroides fragilis, Fusobacterium nucleatum, and pks(+)Escherichia coli, promote carcinogenesis by …
Faecalibacterium prausnitzii Ameliorates DSS-Induced Colitis via Modulating Bile Acid Metabolism and Regulating FXR Signaling
Publication Year: 2025 Source: Dig Dis Sci PMID: 40617891
BACKGROUND: Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with a globally increasing incidence. Faecalibacterium prausnitzii (F. prausnitzii) is known for its anti-inflammatory and immunomodulatory properties. However, the mechanisms by which gut microbiota and bile acid metabolism contribute to the therapeutic effects of F. prausnitzii in colitis remain …
Sonographic Transmural Induction Outcomes Across Advanced Therapies in Crohn's Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40618289
PURPOSE: Intestinal ultrasound (IUS) is increasingly being used to evaluate induction efficacy in both clinical practice and clinical trials. We aimed to quantify the rates of induction IUS transmural (TM) remission and response across advanced therapies (AT) in Crohn's disease (CD). METHODS: Single-center retrospective review of patients with CD initiating …
Rectosigmoid endometriosis, a rare cause of lower GI bleeding in a premenopausal woman: Case report
Publication Year: 2025 Source: Int J Surg Case Rep PMID: 40618668
INTRODUCTION AND IMPORTANCE: Endometriosis is a common gynecological condition where endometrial-like tissue grows outside the uterus, often affecting the ovaries, peritoneum, and pelvic ligaments. Sigmoid endometriosis is a rare manifestation that can present with nonspecific gastrointestinal symptoms, often mimicking conditions like irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD), …
Relationship between bone marrow fat fraction and risk of anaemia in patients with Crohn's disease: a cross-sectional study based on chemical shift-encoded magnetic resonance imaging (CSE-MRI)
Publication Year: 2025 Source: Clin Radiol PMID: 40618680
AIM: To investigate the relationship between anaemia and bone marrow fat fraction (BMFF) based on chemical shift-encoded magnetic resonance imaging (CSE-MRI) in Crohn's disease (CD) patients. MATERIALS AND METHODS: A total of 103 patients with CD and 67 healthy volunteers were enrolled in this study. Differences in BMFF, red blood …
RONS clearing TePt @ sodium carboxymethyl cellulose nanozymes for chronic enteritis therapy
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40618809
Chronic enteritis is a prevalent inflammatory disease that can progress to acute enteritis and even intestinal cancer if not promptly treated. This inflammation is often associated with the overproduction of reactive oxygen and nitrogen species (RONS), which disrupt the cellular redox homeostasis and induce significant damage to cells and tissues. …
Efficacy of etrasimod in ulcerative colitis: analysis of ELEVATE UC 52 and ELEVATE UC 12 by baseline endoscopic severity
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40618942
BACKGROUND AND AIMS: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate (S1P)(1,4,5) receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). In this post hoc analysis, induction and maintenance efficacy of etrasimod 2 mg vs placebo were assessed by baseline Mayo endoscopic subscore (ES) in ELEVATE …
Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial growth factor receptor 2 pathway in inflammatory bowel disease
Publication Year: 2025 Source: J Adv Res PMID: 40619121
OBJECTIVES: Immune-driven inflammatory angiogenesis is a crucial component in the pathogenesis of inflammatory bowel disease (IBD). Nevertheless, the underlying mechanisms are still poorly understood. This study aims to investigate the role of Transglutaminase 2 (TGM2) in inflammatory angiogenesis in IBD and its potential as a therapeutic target and biomarker. METHODS: …
Synergistic effects of oral exclusive enteral nutrition and biologics in induction therapy for adult Crohn's disease: A real-world observational study
Publication Year: 2025 Source: Dig Liver Dis PMID: 40619317
BACKGROUND: Exclusive enteral nutrition (EEN) is recommended as first-line induction therapy for pediatric Crohn's disease (CD), but its use in adults, especially alongside biologics, is limited. This study evaluated the effectiveness of a structured oral EEN approach combined with biologics as induction therapy in adult active CD. METHODS: A total …
The prevalence of polypharmacy increases with age among patients with inflammatory bowel disease: A nationwide cohort study
Publication Year: 2025 Source: Br J Clin Pharmacol PMID: 40619646
AIMS: Polypharmacy is common in adult patients with inflammatory bowel disease (IBD). This study aims to quantify medication prescriptions and estimate the risk of polypharmacy over time in older adults with IBD. METHODS: In a nationwide cohort of adult incident IBD patients from 1 April 1996, to 31 December 2019, …
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