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AMP-Activated Protein Kinase mediates the anti-inflammatory and antioxidant effects of Ceiba speciosa and Ceiba insignis in a rat model of ulcerative colitis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 40389087
ETHNOPHARMACOLOGICAL RELEVANCE: Genus Ceiba, (Malvaceae) encompasses 200 species that naturally thrive in tropical and subtropical regions worldwide as West Africa, South Asiam Mexico, Central America, South America, the Bahamas and the Caribbean. Ceiba speciosa (A.St.-Hil.) Ravenna (CS) and Ceiba insignis (Kunth) P.E.Gibbs & Semir (CI) were traditionally used for treatment …
Inflammatory bowel disease, age of its onset and incident psychiatric disorders: The role of post-IBD lifestyle and medications
Publication Year: 2025 Source: J Affect Disord PMID: 40389176 DOI: 10.1016/j.jad.2025.119420
BACKGROUND: Individuals with inflammatory bowel disease (IBD) are at an increased risk to developing psychiatric disorders (PDs). However, the age of onset patterns for IBD-related PDs and the role of post-IBD lifestyle on the risk of subsequent PDs remain unclear. METHODS: 394,851 PD-free participants at baseline from the UK Biobank …
Prophylactic administration of overproducing-abscisic acid Bacillus licheniformis attenuated DSS-induced colitis in mice by regulating the gut microbiota and immune activity
Publication Year: 2025 Source: BMC Microbiol PMID: 40389822 DOI: 10.1186/s12866-025-03988-4
BACKGROUND: Inflammatory bowel disease (IBD) involves the complex interplay among the mucosal barrier, microbiota, immunity and genetic factors. There are currently no satisfactory treatments for IBD. Administration of the probiotic Bacillus licheniformis (Bl) can improves colitis by regulating the gut microbiota. The phytohormone abscisic acid (ABA) treatment has favorable effects …
Effect of pemafibrate in reducing intestinal long-chain fatty acid absorption and hepatic fibrosis in metabolic dysfunction-associated steatohepatitis rats
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40389836
BACKGROUND: Pemafibrate helps regulate fatty acid dynamics in the liver, potentially preventing metabolic dysfunction-associated steatohepatitis (MASH). However, its effect on intestinal long-chain fatty acid (LCFA) metabolism in MASH remains unclear. Thus, we aimed to examine the influence of pemafibrate on intestinal LCFA metabolism and hepatic fibrosis in a MASH rat …
[Study on the underlying autonomic nervous mechanism of electroacupuncture in improving colonic inflammation in mice with chronic ulcerative colitis]
Publication Year: 2025 Source: Zhen Ci Yan Jiu PMID: 40390614
OBJECTIVES: To observe the effect of electroacupuncture (EA) at "Tianshu" (ST25) on colonic inflammatory response in mice with ulcerative colitis (UC), so as to explore its underlying mechanisms in anti-inflammatory. METHODS: In the first part of this study, 36 male C57BL/6J mice were randomly divided into normal, model, and EA …
Tailoring therapy to the individuals of Crohn's disease
Publication Year: 2025 Source: Sci Prog PMID: 40390651
For decades, increasing incidence and prevalence of Crohn's disease (CD) have attracted more attention. Some severe complications such as perforations, fistulas, and abscesses have significantly impaired patients' quality of life. Though the emergence of biologic agents has improved disease course and prognosis to a great extent, different disease manifestations and …
Restoring Prostacyclin/PGI2-PTGIR signaling alleviates intestinal fibrosis in Crohn's disease via fibroblast-specific YAP/TAZ inhibition
Publication Year: 2025 Source: J Crohns Colitis PMID: 40390655
BACKGROUND AND AIMS: Intestinal obstruction caused by fibrosis is a common and serious complication of Crohn's disease (CD). Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motifs (TAZ), the transcriptional effectors of the Hippo signaling pathway, have emerged as key drivers of intestinal fibrosis. Systematic inhibition of YAP/TAZ failed to …
The angiotensin receptor blocker, losartan, reduces inflammation and fibrosis, and prevents relapse of fibrosis after steroid-induced remission, in mice prone to Crohn's disease-like ileitis
Publication Year: 2025 Source: J Crohns Colitis PMID: 40390697
BACKGROUND AND AIMS: The renin-angiotensin system (RAS) is known to modulate fibrosis, which is a common complication of ileal Crohn's disease. We tested the efficacy of losartan, an angiotensin receptor blocker, to treat intestinal fibrosis in relevant preclinical models of Crohn's-like disease. METHODS: Effector molecules of the RAS were mined …
Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease
Publication Year: 2025 Source: Front Immunol PMID: 40391223 DOI: 10.3389/fimmu.2025.1600838
INTRODUCTION: Inflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology. The exploration of novel intervention strategies remains a key scientific issue that is urgently needed for IBD treatment. The hygiene hypothesis has led researchers to notice that worm infections …
Correction to: Identification of the M2 Macrophage-associated Gene THBS2 as a Predictive Marker for Inflammatory Cancer Transformation
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40391572
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