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Twenty Years of Disease Modifying Anti-Inflammatory Bowel Disease Drug Use Preceding Colectomy for Refractory Inflammatory Bowel Disease-Associated Colitis
Publication Year: 2025 Source: Dis Colon Rectum PMID: 40391725 DOI: 10.1097/DCR.0000000000003826
BACKGROUND: Disease modifying anti-inflammatory bowel disease drugs (DMAIDs), such as infliximab, have altered treatment of inflammatory bowel disease. Despite increasing availability of disease modifying anti-inflammatory bowel disease drugs, many individuals with inflammatory bowel disease still require surgical resection and the role of disease modifying anti-inflammatory bowel disease drugs in delaying …
Editorial: Getting to the Heart of the Matter in IBD
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40391742 DOI: 10.1111/apt.70177
No Abstract
Editorial: Getting to the Heart of the Matter in IBD-Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40391754 DOI: 10.1111/apt.70201
No Abstract
Serum biomarkers of collagen remodeling are associated with intestinal fibrosis and differentiate stenotic from luminal Crohn's disease patients: a pre- and post-resection longitudinal study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40391838
BACKGROUND AND AIMS: Crohn's disease (CD) is characterized by progressive intestinal transmural damage, including fibrosis and strictures, which impair quality of life and require surgical intervention. No anti-stricture therapies are available, and no accurate biomarkers have been validated allowing prediction of strictures. Collagen fragments synthesis and remodeling show potential as …
Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease
Publication Year: 2025 Source: Elife PMID: 40392591 DOI: 10.7554/eLife.101932
Inflammatory bowel disease (IBD) is a chronic and relapsing immune-mediated disorder characterized by intestinal inflammation and epithelial injury. The underlying causes of IBD are not fully understood, but genetic factors have been implicated in genome-wide association studies, including CTLA-4, an essential negative regulator of T cell activation. However, establishing a …
The impact of a multi-species probiotic supplementation on clinical symptoms and biochemical factors in patients with irritable bowel syndrome: a randomised controlled trial
Publication Year: 2025 Source: Arch Physiol Biochem PMID: 40392916
Background: Intestinal inflammation and oxidative stress contribute to the pathophysiology of irritable bowel syndrome (IBS). This clinical trial investigated the effects of a probiotic supplementation on symptom severity and quality of life (QOL) in IBS patients. Methods: Forty-six IBS patients were randomised to receive either a multi-species probiotic or placebo …
A rapid accurate approach to inferring pedigrees in endogamous populations
Publication Year: 2025 Source: Genetics PMID: 40393068 DOI: 10.1093/genetics/iyaf094
Accurate reconstruction of pedigrees from genetic data remains a challenging problem. Many relationship categories (e.g. half-sibships versus avuncular) can be difficult to distinguish without external information. Pedigree inference algorithms are often trained on European-descent families in urban locations. Thus, existing methods tend to perform poorly in endogamous populations for which …
Faecalibacterium Prausnitzii extracellular vesicles regulating macrophage differentiation via homologous recombination repair in colitis model
Publication Year: 2025 Source: Microbiol Res PMID: 40393169 DOI: 10.1016/j.micres.2025.128217
Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation influenced by the depletion of beneficial gut microbiota, a critical factor in disease onset and progression. This study investigates the therapeutic potential of extracellular vesicles (EVs) derived from Faecalibacterium prausnitzii (F.p EVs), a commensal bacterium whose reduction is linked to IBD. …
Impact of ultra-processed foods on human health: A comprehensive review of genomic instability and molecular mechanisms
Publication Year: 2025 Source: Nutrition PMID: 40393283
In this review the nexus between genomic instability and human health is investigated, emphasizing the rising consumption of ultra-processed foods (UPFs). Introducing the NOVA food classification system, we explore the significant surge in UPF consumption over the past 3 decades and its correlation with heightened mortality rates. This exploration extends …
Converting indoprofen to moderate selective COX-2 inhibitors: Design, synthesis and biological evaluation
Publication Year: 2025 Source: Bioorg Chem PMID: 40393356
Moderate COX-2 inhibitors with favorable safety profiles might benefit the treatment of ulcerative colitis. Herein, biochemical differences between COX-1 and COX-2 enzymes were exploited to identify a strategy for converting the nonsteroidal anti-inflammatory drug indoprofen into moderately selective COX-2 inhibitors through the installation of amides (7a-7y) and sulfonamides (8a-8g) at …
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