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Inter-rater Reliability and Accuracy of NBI Score for Activity Evaluation in Ulcerative Colitis
Publication Year: 2025 Source: Rev Recent Clin Trials PMID: 40619668
BACKGROUND: Colonoscopy is a critical tool for the management of Ulcerative Colitis (UC). In this study, we aim to explore the accuracy of Virtual Chromoendoscopy (VCE) using Narrow Banding Imaging (NBI), and magnification using Near Focus (NF) for a better definition of endoscopic inflammation grade in UC patients compared to …
Research trends and hotspots of nanomaterials in inflammatory bowel disease: a bibliometric analysis
Publication Year: 2025 Source: Nanomedicine (Lond) PMID: 40619849
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic and nonspecific gastrointestinal disorder, imposing significant physical, emotional, and economic burdens on patients. In recent years, nanomaterials have shown great potential in the management of IBD. This study employs bibliometric analysis to map global research trends and intellectual landscapes in nanomaterials application …
Traditional Chinese medicine and gut microbiota: biotransformation, interaction, and implications for chronic disease treatment
Publication Year: 2025 Source: Drug Metab Rev PMID: 40620235
The gut microbiota (GM), often regarded as a vital 'functional organ,' plays a crucial role in human physiological processes. GM is involved in substance metabolism, especially the biotransformation of pharmaceuticals. It modulates drug pharmacological activity and bioavailability through various metabolic pathways. Since traditional Chinese medicine (TCM) is primarily administered orally, …
A proposed comprehensive model of care for inflammatory bowel disease in Poland
Publication Year: 2025 Source: Prz Gastroenterol PMID: 40620300
Epidemiological data of the Polish healthcare model of care indicate that the current management of inflammatory bowel disease (IBD) requires improvements in clinical practice and service organization. Integrated care models for patients with IBD, particularly those centred on a multidisciplinary team, offer a promising approach to improving outcomes, reducing admissions, …
Markers of bacterial translocation as a possible indicator of subclinical inflammation in pediatric inflammatory bowel diseases patients
Publication Year: 2025 Source: Prz Gastroenterol PMID: 40620305
INTRODUCTION: Recently there has been significant progress in research on the pathogenesis of inflammatory bowel diseases (IBD). AIM: Our study aimed to assess selected markers of bacterial translocation in children with IBD in relationship to disease activity. MATERIAL AND METHODS: Lipopolysaccharides (LPS) - markers of bacterial translocation - and proinflammatory …
Sexual dysfunction in patients with inflammatory bowel disease
Publication Year: 2025 Source: Prz Gastroenterol PMID: 40620307
INTRODUCTION: Inflammatory bowel diseases (IBD) significantly influence sexual function due to their symptoms. The impact of the disease on sexuality and intimacy is a predominant concern for IBD patients, though data on sexual (SD) and erectile dysfunction (ED) and their determinants remain scarce. AIM: The aim of this study was …
A Randomized Controlled Pilot Study Evaluating the Safety and Efficacy of Nifuroxazide in Patients with Ulcerative Colitis
Publication Year: 2025 Source: Drug Des Devel Ther PMID: 40620467
BACKGROUND: The therapeutic potential of nifuroxazide in colitis has been explored in several experimental studies of ulcerative colitis (UC). AIM: To evaluate the efficacy of nifuroxazide in patients with UC. METHODS: Fifty patients with mild to moderate UC were randomly assigned into two groups (n = 25 each). The placebo …
Exploring the Causal Link Between Autoimmune Diseases and Pulmonary Arterial Hypertension: A Bidirectional Mendelian Randomization Study
Publication Year: 2025 Source: Glob Heart PMID: 40620598
BACKGROUND: Pulmonary arterial hypertension (PAH) is a severe vascular disorder with a multifactorial etiology, including potential genetic predispositions. Understanding the causal relationship between autoimmune diseases and the risk of developing PAH can inform clinical strategies for prevention and treatment. METHODS: We conducted a two-sample Mendelian Randomization (MR) analysis to evaluate …
Predictive value of long non-coding RNA DDX11-AS1 in inflammatory bowel disease and its effect on intestinal mucosal cell function
Publication Year: 2025 Source: Cent Eur J Immunol PMID: 40620651
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic and recurrent autoimmune condition. Numerous studies have reported that non-coding RNA, especially long non-coding RNA (lncRNA), plays a significant role in the regulation of IBD. This study sought to investigate the expression of lncRNA DDX11-antisense RNA 1 (DDX11-AS1) in IBD and its …
Identification of neutrophil extracellular trap-related biomarkers in ulcerative colitis based on bioinformatics and machine learning
Publication Year: 2025 Source: Front Genet PMID: 40620701
BACKGROUND: The incidence of ulcerative colitis (UC) is rapidly increasing worldwide, but existing therapeutics are limited. Neutrophil extracellular traps (NETs), which have been associated with the development of various autoimmune diseases, may serve as a novel therapeutic target for UC treatment. METHODS: Bioinformatics analysis was performed to investigate UC-related datasets …
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