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Research trends and hotspots of metabolites and inflammatory bowel disease: a bibliometric analysis
Publication Year: 2025 Source: Front Microbiol PMID: 40365072 DOI: 10.3389/fmicb.2025.1548233
PURPOSE: The purpose of this study is to analyze the current research status and explore the relationship between metabolites and inflammatory bowel disease (IBD), providing insights for future research. METHODS: In this study, we retrieved publications on metabolites and IBD from the Web of Science Core Collection (WOSCC), covering the …
Natural history, immunological and genetic characteristics of preclinical inflammatory bowel disease (EARLY): study protocol for a prospective cohort study
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40365077 DOI: 10.1177/17562848251338647
BACKGROUND: The period prior to the diagnosis of inflammatory bowel disease (IBD), defined as the preclinical phase, has emerged as a potential target for disease modification strategies. Despite the relevance of an early diagnosis to the prognosis of the disease, only a limited number of patients are diagnosed during this …
Plasma Concentration of Calprotectin, but Not Serum Concentration, Is a Predictive Biomarker for Clinical Remission in Ulcerative Colitis
Publication Year: 2025 Source: Inflamm Intest Dis PMID: 40365553 DOI: 10.1159/000545722
INTRODUCTION: Fecal calprotectin is a validated biomarker for assessing disease activity in patients with inflammatory bowel disease (IBD). Blood calprotectin concentrations are correlated with disease activity in numerous immune-mediated inflammatory diseases. The aim of this study was to prospectively assess the diagnostic accuracy of plasma calprotectin as a potential biomarker …
Treatment of pruritus in primary sclerosing cholangitis: Analysis of the consortium for autoimmune liver disease registry
Publication Year: 2025 Source: Hepatol Commun PMID: 40366147
BACKGROUND: Cholestasis from primary sclerosing cholangitis (PSC) frequently causes pruritus. However, the prevalence of pruritus and its management have not been well studied. Investigating the Cholestatic Pruritus of Primary Sclerosing Cholangitis (ItCh-PSC) includes a retrospective medical record review to determine the prevalence, severity, and treatment patterns of pruritus. METHODS: Data …
Predicting ustekinumab treatment response in Crohn's disease using pre-treatment biopsy images
Publication Year: 2025 Source: Bioinformatics PMID: 40366737
MOTIVATION: Crohn's disease (CD) exhibits substantial variability in response to biological therapies such as ustekinumab (UST), a monoclonal antibody targeting interleukin-12/23. However, predicting individual treatment responses remains difficult due to the lack of reliable histopathological biomarkers and the morphological complexity of tissue. While recent deep learning methods have leveraged whole-slide …
Deep learning-based detection of bacterial swarm motion using a single image
Publication Year: 2025 Source: Gut Microbes PMID: 40366861 DOI: 10.1080/19490976.2025.2505115
Motility is a fundamental characteristic of bacteria. Distinguishing between swarming and swimming, the two principal forms of bacterial movement, holds significant conceptual and clinical relevance. Conventionally, the detection of bacterial swarming involves inoculating samples on an agar surface and observing colony expansion, which is qualitative, time-intensive, and requires additional testing …
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases
Publication Year: 2025 Source: MAbs PMID: 40367237
Tumor necrosis factor-alpha (TNFalpha) is a key pro-inflammatory cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, and neurodegenerative disorders such as Alzheimer's disease. Effective inhibition of TNFalpha is essential for mitigating disease progression and improving patient outcomes. In this study, we …
Assessing Gastrointestinal Awareness on TikTok: A Content Analysis of Colorectal Cancer, IBS, and IBD Narratives
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40367487 DOI: 10.14309/ajg.0000000000003539
INTRODUCTION: Social media platforms such as TikTok are major sources of health information but raise concerns about misinformation. METHODS: We conducted a content analysis of the top 200 TikTok videos on colorectal cancer, irritable bowel syndrome, and inflammatory bowel disease. Videos were categorized by content focus and narrator type. RESULTS: …
Qilian Jiechang Ning Alleviates TNBS-Induced Ulcerative Colitis in Mice and Segatella copri Outer Membrane Vesicle-Triggered Inflammation in Colon Epithelial Cells via the Caspase-1/11-GSDMD Pathways
Publication Year: 2025 Source: J Innate Immun PMID: 40367931
INTRODUCTION: Qilian Jiechang Ning (QJN), a traditional Chinese herbal formula, has demonstrated potential therapeutic effects in the treatment of ulcerative colitis (UC). This study aims to investigate the mechanism of QJN in the outer membrane vesicles (OMVs) of Segatella copri (S. copri)-induced colon epithelial cells and UC mice. METHODS: Transmission …
Too Old to Treat? Rethinking Steroid-sparing Therapy in Elderly-onset Inflammatory Bowel Disease
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40368133
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