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SHERLOCK, a novel CRISPR-Cas13a-based assay for detection of infectious bursal disease virus
Publication Year: 2025 Source: J Virol Methods PMID: 40368251 DOI: 10.1016/j.jviromet.2025.115185
Infectious bursal disease (IBD) is an extremely contagious viral infection that primarily affects young chicks, leading to significant economic losses in the poultry industry. The disease is caused by a double-stranded RNA virus of the genus Avibirnavirus, family Birnaviridae, namely, the infectious bursal disease virus (IBDV). Unfortunately, current methods for …
Incorporating zinc coordination driven nanozyme into chitosan and hyaluronic acid based nanoplatform for scavenging H(2)S/ROS in managing inflammatory bowel disease
Publication Year: 2025 Source: Carbohydr Polym PMID: 40368544 DOI: 10.1016/j.carbpol.2025.123501
Inflammatory bowel disease (IBD) causes damage to patients, and therapy remains a crucial challenge owing to the presence of excessive reactive oxygen species (ROS) and hydrogen sulfide (H(2)S) in colonic inflammatory circulation. Herein, we report a shikonin (SK) and zinc (Zn) driven coordination nanozyme (SK-Zn, S-Z), which effectively scavenged ROS …
Targeting symbionts by apolipoprotein L proteins modulates gut immunity
Publication Year: 2025 Source: Nature PMID: 40369072
The mammalian gut harbours trillions of commensal bacteria that interact with their hosts through various bioactive molecules(1,2). However, the mutualistic strategies that hosts evolve to benefit from these symbiotic relationships are largely unexplored. Here we report that mouse enterocytes secrete apolipoprotein L9a and b (APOL9a/b) in the presence of microbiota. …
Magnetic resonance enterography to predict subsequent disabling Crohn's disease in newly diagnosed patients (METRIC-EF)-multivariable prediction model, multicentre diagnostic inception cohort
Publication Year: 2025 Source: Eur Radiol PMID: 40369265
OBJECTIVES: Magnetic resonance enterography (MRE) is a first-line investigation to diagnose Crohn's disease (CD), but its role for prognostication is unknown. Accordingly, we assessed the predictive ability of prognostic models including MRE scores (MRE Global Score (MEGS), simplified MR Index of Activity (sMARIA), and Lemann index (LI)) against models using …
[Study on activation mechanism of SGCs in representation along the distribution of stomach meridian in IBS-D mice]
Publication Year: 2025 Source: Zhongguo Zhen Jiu PMID: 40369914
OBJECTIVE: To explore the peripheral neural mechanism underlying representation along the distribution of stomach meridian induced by intestinal inflammatory reaction using diarrhea predominant-irritable bowel syndrome (IBS-D) mice. METHODS: Among 62 healthy male C57BL/6 mice of clean grade, 12 mice were randomly selected and divided into a control group and a …
[Effects of electroacupuncture at changbing fang on autophagy of colonic cells and gut microbiota in ulcerative colitis of rats]
Publication Year: 2025 Source: Zhongguo Zhen Jiu PMID: 40369923
OBJECTIVE: To observe the effects of electroacupuncture (EA) at changbing fang (prescription for intestinal disease) on autophagy of colonic cells and gut microbiota in rats with ulcerative colitis (UC), and to explore the mechanism of EA in the treatment of UC. METHODS: Thirty-two SD male rats were randomly divided into …
Real-World Effectiveness and Safety of Vedolizumab in Patients ≥ 70 Versus < 70 Years With Ulcerative Colitis: Multicenter Retrospective Study
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40370285
BACKGROUND AND AIM: Vedolizumab (VDZ) is often used in older patients with ulcerative colitis (UC) in clinical practice; however, real-world evidence is still limited, including in those with late-onset UC. METHODS: This post hoc analysis of a multicenter, retrospective, observational chart review, enrolling 370 patients with UC receiving VDZ between …
Upadacitinib as Rescue Therapy in a Pregnant Patient With IBD
Publication Year: 2025 Source: ACG Case Rep J PMID: 40370416 DOI: 10.14309/crj.0000000000001701
Upadacitinib is an oral Janus kinase inhibitor approved to treat moderate-to-severe ulcerative colitis. Studies have shown that upadacitinib is highly effective, though use has been limited in certain populations due to concerns of side effects. Outside of animal studies and rare case reports, there are little data for the safety …
Potential applications and mechanisms of natural products in mucosal-related diseases
Publication Year: 2025 Source: Front Immunol PMID: 40370438
The mucosal barrier serves as a crucial defense against external pathogens and allergens, being widely distributed across the respiratory, gastrointestinal, urogenital tracts, and oral cavity. Its disruption can lead to various diseases, including inflammatory bowel disease, asthma, urinary tract infections, and oral inflammation. Current mainstream treatments for mucosa-associated diseases primarily …
Gut microbiota - bidirectional modulator: role in inflammatory bowel disease and colorectal cancer
Publication Year: 2025 Source: Front Immunol PMID: 40370465 DOI: 10.3389/fimmu.2025.1523584
The gut microbiota is a diverse ecosystem that significantly impacts human health and disease. This article focuses on how the gut microbiota interacts with inflammatory bowel diseases and colorectal tumors, especially through immune regulation. The gut microbiota plays a role in immune system development and regulation, while the body's immune …
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