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cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products
Publication Year: 2025 Source: Front Nutr PMID: 40621423
Digestive diseases remain a major challenge to public health systems globally. Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon gene (STING) play important roles in innate immunity as well as inflammatory responses. Dysregulation of the cGAS-STING pathway has been demonstrated to be an important pathogenetic mechanism in diverse gastrointestinal diseases. …
Biomarker discovery for non-invasive diagnosis of inflammatory bowel disease using blood transcriptomics
Publication Year: 2025 Source: Front Immunol PMID: 40621466
INTRODUCTION: Colonoscopy remains the gold standard for diagnosing inflammatory bowel disease (IBD) even though it is an invasive and costly procedure. To enable non-invasive diagnosis, we aimed to identify blood-based transcriptomic biomarkers that specifically distinguish IBD from healthy and inflammatory controls. METHODS: Public microarray and RNA-seq datasets from whole blood …
Quantitative and qualitative assessment of diet and its association with disease activity in pediatric ulcerative colitis
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40621635
OBJECTIVES: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with increasing global prevalence, particularly in newly industrialized countries. While diet has been implicated in disease pathogenesis, its role in modifying clinical outcomes remains unclear. This study aimed to evaluate dietary intake and habits in pediatric UC patients and assess …
Management of pediatric inflammatory bowel diseases in limited-resource settings: A position paper from the Paediatric IBD Porto Group of ESPGHAN
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40621690
OBJECTIVE: Pediatric inflammatory bowel diseases (PIBDs), despite being more prevalent in westernized nations, show an increasing incidence worldwide. Accurate evaluation, diagnosis, therapy, and monitoring are mandatory for the adequate management of patients, as is a sensible use of expensive resources, which may be limited in some parts of the world. …
The total gut mucosal and fecal bacterial load increases in successful treatment of inflammatory bowel disease with infliximab
Publication Year: 2025 Source: Microbiol Spectr PMID: 40621920
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory gastrointestinal disorders linked to genetic predisposition and environmental factors. The gut microbiota, composed of various microorganisms, plays a crucial role in IBD, as reduced anaerobic bacteria and short-chain fatty acid (SCFA) producers are associated with …
A Population-Based Assessment of Physical Activity and Exercise in Persons With IBD
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 40622220
GOALS/BACKGROUND: We aimed to assess the physical activity (PA) and exercise profiles of persons with IBD, their limitations in undertaking PA/exercise, and how PA correlates with active disease and fatigue in a Canadian population-based sample. STUDY: A cross-sectional survey study was undertaken by participants in the University of Manitoba IBD …
Trends in Substance Use Disorder Among Hospitalized Patients With Inflammatory Bowel Disease: An 11-Year Nationwide Study
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 40622248
GOALS: We described the temporal trend of substance use disorder (SUD) and SUD subtypes among patients hospitalized with inflammatory bowel disease (IBD), accounting for readmissions within the calendar year. BACKGROUND: One in six patients with IBD is estimated to have a concomitant SUD. SUD has had mounting morbidity and mortality …
Novel Autologous Regulatory T-Cell Therapy Ameliorates DSS-Induced Colitis in Humanized Mice
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40622253
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with a complex immune-mediated pathogenesis. The efficacy of human-specific cellular immunotherapies and biological medications cannot be accurately evaluated using traditional murine IBD models. Therefore, a humanized mouse model of IBD is necessary. Regulatory T cells (Tregs) are critical for maintaining …
Infection of Mice with Cryptococcus neoformans to Evaluate Its Dissemination to the Central Nervous System
Publication Year: 2025 Source: Methods Mol Biol PMID: 40622533
Cryptococcus neoformans has strong tropism for the central nervous system (CNS), causing meningoencephalitis that is fatal without treatment. While several factors are implicated in its ability to cross the blood-brain barrier (BBB), the mechanisms driving CNS entry remain unclear. Mouse models of cryptococcosis, including strains such as C57BL/6 J, A/J, …
Cryptococcus neoformans and Microglia In Vitro Interaction as a Tool to Study Central Nervous System Infection
Publication Year: 2025 Source: Methods Mol Biol PMID: 40622534
This chapter presents in vitro protocols for studying interactions between Cryptococcus neoformans and microglial cells. These phagocytes are a critical component of the central nervous system's immune response to C. neoformans, the most common fungal agent of meningoencephalitis worldwide. Given its severity and high incidence in immunocompromised patients, understanding the …
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