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A complex role of chromogranin A and its peptides in inflammation, autoimmunity, and infections
Publication Year: 2025 Source: Front Immunol PMID: 40370467 DOI: 10.3389/fimmu.2025.1567874
Chromogranin A (CgA), mostly known as a nonspecific neuroendocrine tumor marker, was the first glycoprotein from the granin family characterized as a prohormone for various bioactive peptides including vasostatin I/II (VS-I, VS-II), catestatin (CST), chromofungin (CHR), pancreastatin (PST), WE-14, and others. CgA and its derivatives present various functions, often antagonistic, …
Unveiling the Cuproptosis in Colitis and Colitis-Related Carcinogenesis: A Multifaceted Player and Immune Moderator
Publication Year: 2025 Source: Research (Wash D C) PMID: 40370501 DOI: 10.34133/research.0698
Cuproptosis represents a novel mechanism of cellular demise characterized by the intracellular buildup of copper ions. Unlike other cell death mechanisms, its distinct process has drawn considerable interest for its promising applications in managing inflammatory bowel disease (IBD) and colorectal cancer (CRC). Emerging evidence indicates that copper metabolism and cuproptosis …
Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40370726 DOI: 10.3389/fmed.2025.1542953
BACKGROUND: Inflammatory Bowel Disease (IBD) is a chronic, idiopathic inflammatory disorder of the intestines. Oxymatrine (OMT) is a naturally active substance found in the desiccated roots of Sophora flavescens. It possesses anti-tumor, antiviral, and anti-inflammatory properties. In recent years, its therapeutic role in IBD has gradually been discovered. This review …
IDO1 induced macrophage M1 polarization via ER stress-associated GRP78-XBP1 pathway to promote ulcerative colitis progression
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40370742
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder distinguished by alternating phases of remission and exacerbation. Restoring immune balance through the modulation of M1 macrophage polarization represents a potentially valuable therapeutic strategy for UC. Indoleamine 2,3-dioxygenase-1 (IDO1) has been shown to contribute to macrophage plasticity, but its role in …
Diagnostic Value of Fecal Lactoferrin in Differentiating Inflammatory Bowel Disease From Irritable Bowel Syndrome: A Comparative Study in a Bangladeshi Cohort
Publication Year: 2025 Source: Cureus PMID: 40370884 DOI: 10.7759/cureus.82187
Background Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) share overlapping symptoms, making differentiation challenging. IBD, which includes ulcerative colitis (UC) and Crohn's disease (CD), involves chronic inflammation requiring long-term management, whereas IBS is a functional gastrointestinal disorder without organic pathology. Fecal lactoferrin, a biomarker of intestinal inflammation, has …
Idiopathic Spontaneous Pneumomediastinum in an Active Patient With Crohn's Disease
Publication Year: 2025 Source: Cureus PMID: 40370918 DOI: 10.7759/cureus.82256
Spontaneous pneumomediastinum (SPM) is a rare complication of inflammatory bowel disease (IBD), often associated with colonic perforations or procedural interventions. This report details a case of a 30-year-old female with ileocolonic Crohn's disease (CD) presenting with idiopathic SPM during an acute CD flare while on prolonged corticosteroid therapy. Imaging confirmed …
Racial disparity in inflammatory bowel disease-related complications: a nationwide cohort study
Publication Year: 2025 Source: Ann Gastroenterol PMID: 40371211 DOI: 10.20524/aog.2025.0958
BACKGROUND: Racial disparities in inflammatory bowel disease (IBD)-related complications are increasingly recognized, yet nationwide data remain limited. This study examined racial differences in IBD-related complications across diverse patient populations. METHODS: We analyzed data from the Nationwide Inpatient Sample 2016-2021, on over 1.7 million weighted hospitalizations for IBD. Adults with Crohn's …
The War in Gaza and Barriers to Inflammatory Bowel Disease Care
Publication Year: 2025 Source: JGH Open PMID: 40371236 DOI: 10.1002/jgh3.70184
OBJECTIVES: Stress is associated with inflammatory bowel disease (IBD) development and exacerbation. We evaluated the impact of the war in Gaza on Israeli IBD patients and related barriers to IBD care. METHODS: Adult IBD patients were blindly enrolled to complete a patient-reported-outcome electronic questionnaire assessing symptoms, hospitalizations, medications, psychosocial factors, …
Post-marketing safety of anakinra and canakinumab: a real-world pharmacovigilance study based on FDA adverse event reporting system
Publication Year: 2025 Source: Front Pharmacol PMID: 40371323
BACKGROUND: Anakinra and canakinumab are two FDA-approved IL-1 blockers indicated for the treatment of multiple autoinflammatory diseases, yet their safety has not been comprehensively analyzed. We aimed to assess the safety signals associated with anakinra and canakinumab by conducting a pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS) …
Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice
Publication Year: 2025 Source: Front Pharmacol PMID: 40371345
BACKGROUND: Resveratrol, a naturally occurring polyphenolic compound found in grapes, berries, and traditional medicinal plants like Polygonum cuspidatum, has been used for centuries in traditional medicine systems for its anti-inflammatory, antioxidant, and cardioprotective properties. Ulcerative colitis (UC), a chronic inflammatory bowel disease, is characterized by intestinal barrier disruption due to …
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