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Infliximab may contribute to remit rapidly progressive of IgA nephropathy secondary to Crohn's disease: A case report
Publication Year: 2025 Source: Technol Health Care PMID: 40371441 DOI: 10.1177/09287329251340770
BackgroundIgA nephropathy (IgAN) is a glomerulonephritis characterized by IgA deposition in the mesangial of the glomerulus, and it is the most common glomerulonephritis. However, many patients with inflammatory bowel disease (IBD) also have secondary IgAN. Compared with primary IgAN, the secondary IgAN may be more complex. Many novel therapies, such …
Cardiovascular Health, Genetic Susceptibility, and the Risk of Incident Autoimmune Disorders in the UK Biobank: A Prospective Cohort Study
Publication Year: 2025 Source: J Am Heart Assoc PMID: 40371604
BACKGROUND: Autoimmune diseases are closely linked to cardiovascular diseases. This study aimed to assess the relationship between cardiovascular health (CVH) defined by Life's Essential 8 (LE8), genetic predisposition, and the risk of 19 autoimmune disorders. METHODS AND RESULTS: A total of 247 660 participants without prior autoimmune diseases from the …
Promoting mucosal healing by targeting TMEM219-dependent intestinal epithelial stem cell defects in inflammatory bowel disease
Publication Year: 2025 Source: J Clin Invest PMID: 40371644 DOI: 10.1172/JCI192640
Inflammatory Bowel Diseases (IBD), including Crohn's disease and ulcerative colitis, pose challenges due to their complex pathophysiology and high prevalence. Despite advances in immune-targeted therapies, a substantial number of patients fail to achieve mucosal healing, highlighting the need for alternative therapeutic strategies. In this issue of the JCI, D'Addio et …
TMEM219 signaling promotes intestinal stem cell death and exacerbates colitis
Publication Year: 2025 Source: J Clin Invest PMID: 40371646 DOI: 10.1172/JCI185783
Mechanisms by which mucosal regeneration is abrogated in inflammatory bowel disease (IBD) are still under investigation, and a role for an intestinal stem cell (ISC) defect is now emerging. Herein, we report an abnormal ISC death that occurs in Crohn's disease, which exacerbates colitis, limits ISC-dependent mucosal repair, and is …
Virome drift in ulcerative colitis patients: faecal microbiota transplantation results in minimal phage engraftment dominated by microviruses
Publication Year: 2025 Source: Gut Microbes PMID: 40371968
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent colonic inflammation. Standard treatments focus on controlling inflammation but remain ineffective for one-third of patients. This underscores the need for alternative approaches, such as fecal microbiota transplantation (FMT), which transfers healthy donor microbiota to patients. The role of viruses …
The Place of Appendicectomy in Inflammatory Bowel Disease-A Review
Publication Year: 2025 Source: ANZ J Surg PMID: 40372363 DOI: 10.1111/ans.70157
The aetiology and pathophysiology of inflammatory bowel disease (IBD) are not completely understood; however, a dysregulated intestinal immune system appears key to its pathogenesis. It has been suggested that the appendix is central to nurturing the enteric mucosal system due to its production of lymphoid products and that an appendicectomy …
Therapeutic effect of Faecalibacterium longum CM04-06 on DSS-induced ulcerative colitis in mice
Publication Year: 2025 Source: J Appl Microbiol PMID: 40372371 DOI: 10.1093/jambio/lxaf119
AIMS: This study explores the impact of Faecalibacterium longum CM04-06 on inflammatory bowel disease (IBD) by regulating gut microbiota in mice. METHODS AND RESULTS: We reanalyzed the distribution of the CM04-06 genome in the metagenome of the IBD cohort and observed a significantly higher abundance of CM04-06 in healthy individuals …
Impact of preoperative use of biologics on 30-day surgical morbidity and mortality in patients with Crohn's disease undergoing ileocolectomy: National Surgical Quality Improvement Program database analysis
Publication Year: 2025 Source: Updates Surg PMID: 40372650
Preoperative use of biologics has been inconsistently reported to be associated with increased frequency of infectious and surgical anastomotic complications in inflammatory bowel disease patients. We aimed to evaluate the rates of 30-day postoperative morbidity and mortality in Crohn's disease patients exposed preoperatively to biologics. Data were collected from the …
Correction to: Post-Discharge Outcomes of Elderly Patients Hospitalized for Inflammatory Bowel Disease Flare Complicated by Clostridioides difficile Infection
Publication Year: 2025 Source: J Crohns Colitis PMID: 40372820
No Abstract
Impact of Clostridioides difficile Infection on the Outcome of Severe Flare of Ulcerative Colitis
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 40372989 DOI: 10.1097/MCG.0000000000002196
BACKGROUND: Clostridioides difficile infection (CDI) and acute severe ulcerative colitis (ASUC) are both independently associated with poor outcome. The impact of CDI on the outcome of severe flare of ulcerative colitis is not studied. In the current study, we assess the impact of CDI on the outcome of ASUC. METHODS: …
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