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Discovery of novel N-(5-chloro-2,4-dimethoxyphenyl)-N-heterocyclic ketone analogs as potent anti-inflammatory agents against ulcerative colitis
Publication Year: 2025 Source: Bioorg Chem PMID: 40373559
As the incidence of ulcerative colitis (UC) has increased globally, there is a great unmet clinical need for efficacious, tolerable, and economical, orally administered drugs for its treatment. To help meet this need, we investigated anti-inflammatory small-molecule drugs with a novel structure, high activity, and high selectivity for the treatment …
A multilevel study on the genetic relationship between schizophrenia and inflammatory bowel disease
Publication Year: 2025 Source: Hum Immunol PMID: 40373620 DOI: 10.1016/j.humimm.2025.111330
BACKGROUND: Schizophrenia (SCZ) and Inflammatory Bowel Disease (IBD) represent significant clinical challenges, frequently co-morbid and potentially linked by a genetic correlation. However, the precise mechanism underlying this correlation remains elusive. METHODS: we utilized genome-wide association study (GWAS) data for SCZ and IBD to evaluate their genetic correlation. Initially, we performed …
Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection
Publication Year: 2025 Source: Immunity PMID: 40373771
The T300A substitution in ATG16L1 associated with Crohn's disease impairs autophagy, yet up to 50% of humans are heterozygous for this allele. Here, we demonstrate that heterozygosity for the analogous substitution in mice (Atg16L1(T316A)), but not homozygosity, protects against lethal Salmonella enterica Typhimurium infection. One copy of Atg16L1(T316A) was sufficient …
Advances in the polysaccharide derivatives for the treatment of inflammatory bowel disease: A review
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40373931 DOI: 10.1016/j.ijbiomac.2025.144192
The incidence of inflammatory bowel disease (IBD) is increasing worldwide and poses a huge economic burden. The disease is difficult to treat and prone to recurrence, which seriously affects the physical and mental health of patients. Several studies have shown that natural polysaccharides have significant advantages in IBD treatment. To …
Conventional treatment of hidradenitis suppurativa: Serving the "window of opportunity" concept
Publication Year: 2025 Source: Clin Dermatol PMID: 40373947
Hidradenitis suppurativa is a chronic, systemic, inflammatory skin disease characterized by inflammatory nodules, painful abscesses, and draining tunnels. It is associated with significant comorbidities, including inflammatory bowel disease, arthritis, pain, and a reduced quality of life. Unlike psoriasis or atopic dermatitis, it can progress from an inflammatory state to a …
Efficacy of digital health technologies in the management of inflammatory bowel disease: an umbrella review
Publication Year: 2025 Source: Lancet Digit Health PMID: 40374487 DOI: 10.1016/j.landig.2024.12.007
The use of digital health technology (DHT) is increasing worldwide. Clinical trials assessing available health tools for the management of patients with inflammatory bowel disease (IBD) are sparse, with limited evidence-based outcome data. In this umbrella review, we investigated the effectiveness of DHT in the care of patients with IBD …
A standardized technique for laparoscopic total colectomy in acute severe ulcerative colitis: a technical note
Publication Year: 2025 Source: Updates Surg PMID: 40374972
Ulcerative colitis (UC) often necessitates total colectomy in cases of medically refractory disease or complications, with over one-third of patients undergoing surgery despite advances in medical therapy. Standardization in colectomy techniques is crucial to improving surgical outcomes, enhancing reproducibility, and addressing variability in practices. This study revisits laparoscopic total colectomy, …
Oral health in inflammatory bowel disease: the overlooked impact and the potential role of salivary calprotectin
Publication Year: 2025 Source: BMC Oral Health PMID: 40375227 DOI: 10.1186/s12903-025-06064-5
BACKGROUND: Inflammatory Bowel Disease (IBD), a chronic condition characterized by gastrointestinal inflammation, is influenced by genetic and environmental factors. Emerging evidence suggests a "mouth-gut axis," with the oral cavity reflecting extra-intestinal manifestations of IBD. This study evaluated the oral health status of IBD patients and the potential of salivary calprotectin …
Bioinformatics analysis reveals shared molecular pathways for relationship between ulcerative colitis and primary sclerosing cholangitis
Publication Year: 2025 Source: Genomics Inform PMID: 40375266 DOI: 10.1186/s44342-025-00045-4
BACKGROUND: Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders, including ulcerative colitis (UC) and Crohn's disease, affecting the gastrointestinal tract and is associated with high morbidity and mortality. Accumulating evidence indicates that IBD not only impacts the gastrointestinal tract but also affects multiple extraintestinal organs, which may …
Endovascular Retrieval of Disconnected Tip From an Iliac Branch Device Stent Graft: A Case Report
Publication Year: 2025 Source: Ann Ital Chir PMID: 40375379 DOI: 10.62713/aic.3784
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