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Outcomes Following Colectomy at For-Profit Hospitals: A National Analysis

Publication Year: 2025 Source: Am Surg PMID: 40375540

BackgroundOne of the most commonly performed operations in the US, colectomy remains associated with a substantial incidence of postoperative complications. While there is increasing recognition that hospital for-profit financial structure may be linked with variation in morbidity, the impact of care at for-profit (FP) hospitals on outcomes following colectomy remains …

A Multicenter Observational Study Comparing Survival of Pugs and Dogs of Other Breeds With Protein-Losing Enteropathy

Publication Year: 2025 Source: J Vet Intern Med PMID: 40375559

BACKGROUND: Protein-losing enteropathy (PLE) in dogs often carries a guarded prognosis, and it is unclear if survival differs among breeds. HYPOTHESIS/OBJECTIVES: Survival of pugs with PLE is shorter than that of other breeds of dogs with PLE. ANIMALS: Forty-seven pugs and 148 dogs of other breeds were diagnosed with PLE …

Enteric glia promotes the survival of CD4 and CD8 T cells in plexitis: a new player in Crohn's disease recurrence?

Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 40375619

The accumulation of immune cells in and around enteric ganglia, called plexitis, is associated with postoperative recurrence in Crohn's disease. Interaction between T cells and enteric glia is increased at the proximal resection margin in patients with Crohn's disease who suffer from postoperative recurrence. However, little is known about the …

The Positive Immunohistochemical Staining of Cytomegalovirus in Colon Biopsy Samples Suggests That the Viral DNA Load in qPCR Is High

Publication Year: 2025 Source: Int J Surg Pathol PMID: 40375791 DOI: 10.1177/10668969251339808

Background and AimImmunohistochemistry (IHC) and/or polymerase chain reaction (PCR) are essential for confirming active cytomegalovirus (CMV) infection in patients with inflammatory bowel disease (IBD). A definitive cut-off has not yet been established; however, Roblin et al suggested a viral load threshold of > 250 viral copies/mg of tissue. In this …

Evolving Trends in Pediatric Inflammatory Bowel Disease Management in Japan: A Decade of Nationwide Data

Publication Year: 2025 Source: JGH Open PMID: 40375856 DOI: 10.1002/jgh3.70175

AIMS: This study aimed to investigate the trends in pediatric inflammatory bowel diseases (IBD) management in Japan over the past decade. METHODS: We retrospectively analyzed data from Japan's nationwide database from 2012 to 2022. Patients aged </= 15 years diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) were included. …

Research Participation in Inflammatory Bowel Disease Studies: What Do Patients Want?

Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40375979 DOI: 10.1093/crocol/otaf016

BACKGROUND: We aimed to determine patient perspectives on inflammatory bowel disease (IBD) research participation and potential changes related to the COVID pandemic experience. METHODS: Participants of the population-based University of Manitoba IBD Research Registry were surveyed March 2022 to March 2023. The survey inquired about views on IBD research participation …

Kurarinone ameliorates intestinal mucosal inflammation via regulating T cell immunity

Publication Year: 2025 Source: Front Immunol PMID: 40375985 DOI: 10.3389/fimmu.2025.1587479

BACKGROUND: Inflammatory bowel disease (IBD) has become an increasingly significant global health concern, imposing substantial economic and psychological burdens on society and public health systems. Herbal medicines, which have shown promise in alleviating IBD symptoms and promoting remission through mechanisms such as immune regulation and anti-inflammatory effects, are gaining increasing …

Environmental footprint of a colonoscopy procedure: Life cycle assessment

Publication Year: 2025 Source: Endosc Int Open PMID: 40376020

BACKGROUND AND STUDY AIMS: Gastroenterology is a specialty that has evolved rapidly over time, especially in terms of advancements in endoscopic procedures. However, these advancements also present challenges, given the substantial resource demands associated with endoscopy procedures. Numerous actions could be taken to develop a resilient healthcare system that consumes …

Dietary patterns and inflammatory bowel disease: a global assessment of eight nutrients by region, gender, and socioeconomic status

Publication Year: 2025 Source: Front Nutr PMID: 40376039 DOI: 10.3389/fnut.2025.1570634

BACKGROUND: This study examines global intake patterns of eight dietary components associated with inflammatory bowel disease (IBD): fruits, non-starchy vegetables, processed meats, unprocessed red meats, saturated fats, monounsaturated fatty acids, omega-6 fatty acids, and dietary fiber. Consumption patterns were analyzed across demographic, geographic, and cultural dimensions, including region, sex, urban-rural …

JAK-STAT Signaling in Autoimmunity and Cancer

Publication Year: 2025 Source: Immunotargets Ther PMID: 40376194

The JAK-STAT pathway is an essential cell survival signaling that regulates gene expressions related to inflammation, immunity and cancer. Cytokine receptors, signal transducer and activator of transcription (STAT) proteins, and Janus kinases (JAKs) are the critical component of this signaling cascade. When JAKs are stimulated by cytokines, STAT phosphorylation, dimerization, …

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