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Stool multiplex PCR assay versus conventional stool tests for detecting gastrointestinal infection as a cause for flare of inflammatory bowel disease
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 40377863 DOI: 10.1007/s12664-025-01773-9
BACKGROUND: In inflammatory bowel disease (IBD), a flare can be due to natural history of disease or due to gastrointestinal infection. Infection is conventionally diagnosed by stool microscopy and culture. Stool multiplex polymerase chain reaction (PCR) assay or Biofire(R) FilmArray((R)) GI Panel is a sensitive and rapid test for detecting …
Sexual functioning in patients with inflammatory bowel diseases (IBD): prevalence, predictors, and potential benefits of cognitive behavioral therapy (CBT)
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40378297 DOI: 10.1080/00365521.2025.2506141
OBJECTIVES: Patients with inflammatory bowel diseases (IBD) express concerns about their disease's effects on intimacy and sexuality. This study assessed sexual dysfunction in IBD patients and indirect beneficial effects of IBD-specific cognitive behavioral therapy (CBT) on improving sexual functioning over time. MATERIALS & METHODS: N = 118 patients participated in …
Investigating the effect of neuro-immune communication on immune responses in health and disease: Exploring immunological disorders
Publication Year: 2025 Source: Cell Immunol PMID: 40378510
Recent recognition of the intricate nervous-immune system interplay has prompted research into the specific cellular components involved in these interactions. Emerging evidence suggests that immune and neural cells collaborate within distinct units and act in concert to regulate tissue function and provide protection. These specialized neuro-immune cell units have been …
The intestinal functions of PXR and CAR
Publication Year: 2025 Source: Pharmacol Res PMID: 40378938 DOI: 10.1016/j.phrs.2025.107779
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are so-called xenobiotic nuclear receptors that play pivotal roles in xenobiotic metabolism and detoxification. Both receptors, highly expressed in the liver and intestine, also have endobiotic functions by regulating the homeostasis of endogenous chemicals. While their hepatic functions are well-documented, the …
Novel microbially transformed bile acids: Biosynthesis, structure, and function
Publication Year: 2025 Source: Pharmacol Res PMID: 40378940
The roles of gut microbiota and microbially modified bile acids in human health have become widely recognized. In the last five years, various microbially modified bile acids (e.g., proteinogenic amino-conjugated bile acids, polyamine-conjugated bile acids, neuroactive amine-conjugated bile acids, methylcysteamine-conjugated bile acids, acylated bile acids, dicarboxylic acid-conjugated bile acids, lithocholic …
Long-term outcomes after elective inguinal hernia mesh-repair in patients with inflammatory bowel disease
Publication Year: 2025 Source: Hernia PMID: 40407929 DOI: 10.1007/s10029-025-03362-3
BACKGROUND: Knowledge of long-term outcomes following elective inguinal hernia mesh-repair in patients with inflammatory bowel disease (IBD) remains limited. Pathophysiological differences between Crohn's disease (CD) and ulcerative colitis (UC) may influence mesh-related complications and recurrence risk. The primary objective was to assess the reoperation risk for mesh-related complications, and secondarily, …
Cannabidiol as an immune modulator: A comprehensive review
Publication Year: 2025 Source: Saudi Pharm J PMID: 40407987
Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has emerged as a promising therapeutic agent due to its diverse pharmacological properties, including potent anti-inflammatory, neuroprotective, and immunomodulatory effects. CBD modulates immune responses, including the regulation of T cell activity, induction of macrophage apoptosis, suppression of pro-inflammatory cytokines, and modulation …
Protocol for the decellularization of human intestinal tissue from patients with inflammatory bowel disease
Publication Year: 2025 Source: STAR Protoc PMID: 40408251 DOI: 10.1016/j.xpro.2025.103829
Decellularization of the human intestine in patients with inflammatory bowel disease (IBD) provides an experimental platform for the investigation of the bowel extracellular matrix (ECM). Here, we present a protocol for removing cellular components from the IBD intestinal tissue while preserving its structure and ECM components. We describe steps for …
Real-world safety assessment of Ixekizumab based on the FDA Adverse Event Reporting System (FAERS)
Publication Year: 2025 Source: PLoS One PMID: 40408459
BACKGROUND: Ixekizumab, a monoclonal antibody targeting IL-17A, is approved for psoriasis (PsO) and psoriatic arthritis (PsA). While clinical trials demonstrate its efficacy, real-world safety insights remain critical due to limitations in detecting rare or delayed adverse events (AEs). METHODS: This study analyzed 28,889 ixekizumab-associated AE reports from the first quarter …
Tri-culture model of intestinal epithelial cell, macrophage, and bacteria for the triggering of inflammatory bowel disease on a microfluidic device
Publication Year: 2025 Source: Eur J Cell Biol PMID: 40409019 DOI: 10.1016/j.ejcb.2025.151495
Inflammatory bowel disease (IBD) involves gastrointestinal inflammation, due to intestinal epithelial barrier destruction caused by excessive immune activation. Conventional cell culture systems do not provide a model system that can recapitulate the complex interactions between epithelial cells, immune cells, and intestinal bacteria. To address this, we developed a microfluidic device …
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