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Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt peroxisome proliferator-activated receptor alpha
Publication Year: 2025 Source: Cell Commun Signal PMID: 40414852 DOI: 10.1186/s12964-025-02249-1
BACKGROUND: Conjugated bile acids (CBAs) induced metabolic dysfunction-associated steatotic liver disease (MASLD) through activating sphingosine-1-phosphate receptor 2 (S1PR2). However, the precise mechanisms have not been fully understood. METHODS: We established a link between CBAs and MASLD in IBD patients with high SphK2 and Villin-SphK2TG mice. Villin-SphK2TG mice were fed high-fat …
Association of the TNFRSF1B-rs1061622 variant with nonresponse to infliximab in ulcerative colitis
Publication Year: 2025 Source: Sci Rep PMID: 40414945 DOI: 10.1038/s41598-025-02463-4
For severe forms of ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), biological therapies, including tumor necrosis factor inhibitors (anti-TNF), are often used. However, these drugs have a high variability in treatment response. Multiple factors, such as genetic variants, can affect this variability. The goal of the study was …
Antisense to human CD39 dysregulates immune metabolism in inflammatory bowel disease
Publication Year: 2025 Source: Cell Mol Immunol PMID: 40415115 DOI: 10.1038/s41423-025-01295-6
Defective CD39 levels contribute to an imbalance between Tregs and Th17 effectors in inflammatory bowel disease (IBD). CD39 initiates an ATP hydrolysis cascade that culminates with the generation of adenosine, an immune metabolite that is key to tissue homeostasis. Human CD39 is regulated by an endogenous antisense RNA (CD39-AS) that …
EXPRESS: Cardiovascular Disease in Inflammatory Bowel Disease Pathophysiology and Risk Factors: A Review
Publication Year: 2025 Source: J Investig Med PMID: 40415193 DOI: 10.1177/10815589251346966
Inflammatory Bowel Disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic systemic immune dysregulated disorders affecting the gastrointestinal tract that often have extraintestinal manifestations. Limited data exists on the cardiovascular (CV) implications of IBD, but a higher prevalence of cardiovascular disease (CVD) has been observed compared to …
Symptomatic from Clostridioides difficile or symptomatic from inflammatory bowel disease: Highlighting diagnostic challenges
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40415398
No Abstract
Screening for Clostridioides difficile in asymptomatic children with inflammatory bowel disease: Are they really asymptomatic?
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 40415400
No Abstract
Clostridium Butyricum 337279 shapes the gut microbiota to attenuate metabolic disorder in diet-induced obese mice
Publication Year: 2025 Source: Front Microbiol PMID: 40415947
AIMS: Obesity is one of the important challenges to public health worldwide. Dysbiotic intestinal microbiota is a key factor in the onset and progression of obesity and related diseases. Short chain fatty acids (SCFAs) derived from butyricogenic bacteria has beneficial effects on obesity. Clostridium Butyricum 337279 (C.B), one of the …
Overcoming Challenges in Electronic Health Record Use in Inflammatory Bowel Disease Care
Publication Year: 2025 Source: Gastroenterol Hepatol (N Y) PMID: 40416307
Electronic health record (EHR) systems were introduced to enhance patient data accessibility and improve care. However, in gastroenterology, particularly in the management of inflammatory bowel disease (IBD), EHRs often place a significant burden on providers. Provider burnout is a growing issue, with EHR tasks such as extensive clinical review, in-basket …
What Is Moderate to Severe Inflammatory Bowel Disease?
Publication Year: 2025 Source: Gastroenterol Hepatol (N Y) PMID: 40416309
No Abstract
Iron modulates barrier integrity and stem cell function of small intestine during experimental colitis
Publication Year: 2025 Source: Front Nutr PMID: 40416374 DOI: 10.3389/fnut.2025.1545956
BACKGROUND: Ulcerative colitis (UC) brings inconvenience to many patients with inflammatory bowel disease (IBD). Although colonic pathology is widely investigated, little attention has been paid to the disorders in small intestine of UC. In this study, we investigated the impairments of UC to small intestine and further explored how iron …
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