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Zanthoxylum bungeanum-Derived Nanobiotics for Effective Against Ulcerative Colitis in Mouse Model
Publication Year: 2025 Source: Int J Nanomedicine PMID: 40416729
INTRODUCTION: Growing research is devoted to the development of plant-derived products as new therapeutic drugs to reduce side effects. Plant-derived exosome-like nanoparticles (ELNs) have shown promising potential in the treatment of colitis. METHODS: As a proof of concept, the efficacy of ELNs from edible Zanthoxylum bungeanum (ZbELNs) in protecting macrophages …
Anti-Infection Efficacy, Osteogenesis Potential, and Biocompatibility of 3D Printed PLGA/Nano-Hydroxyapatite Porous Scaffolds Grafted with Vancomycin/DOPA/rhBMP-2 in Infected Rabbit Bone Defects
Publication Year: 2025 Source: Int J Nanomedicine PMID: 40416730 DOI: 10.2147/IJN.S514978
BACKGROUND: Given the limitations of traditional therapies, the treatment of infected bone defects (IBD) remains a great challenge. It is urgent to find a novel method that can simultaneously eradicate infection and promote new bone formation. With the increasing application of personalized scaffolds in orthopedics, novel biomaterials with both antibacterial …
Empagliflozin as treatment in glycogen storage disease type IB patients
Publication Year: 2025 Source: Mol Genet Metab Rep PMID: 40416752 DOI: 10.1016/j.ymgmr.2025.101226
BACKGROUND: Glycogen Storage Disease Ib (GSD Ib) is a disease that associates both neutropenia and neutrophil dysfunction, thereby causing recurrent infections and inflammatory bowel disease (IBD). As of now, the standard treatment of these complications has been the administration of granulocyte-stimulating factor (GCSF). However, recent studies have found that the …
Takotsubo Cardiomyopathy With an Unusually High Troponin Level Post-laparotomy for Small Bowel Obstruction Secondary to Adhesions in a Patient Presenting With Pelvic Inflammatory Disease
Publication Year: 2025 Source: Cureus PMID: 40416914
Pelvic inflammatory disease (PID) triggering adhesion-related small bowel obstruction (SBO) is rare. The occurrence of Takotsubo cardiomyopathy (TCM) with an unusually high level of troponin I in the clinical course presents a unique diagnostic challenge. We report the case of a female patient in her 40s who had repeatedly presented …
Insights Into Cell Therapies for Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastroenterol Hepatol (N Y) PMID: 40416917
No Abstract
Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects
Publication Year: 2025 Source: Front Immunol PMID: 40416976 DOI: 10.3389/fimmu.2025.1558845
INTRODUCTION: Inflammatory bowel disease (IBD) is a complex immune-mediated condition, and biologics are the most commonly used drugs for its treatment. However, there are still cases of ineffective treatment. B-cell lymphoma 6 (Bcl6), a transcriptional suppressor, is known to have regulatory effects on multiple immune-associated cell subsets. FX1, a novel …
Colorectal Cancer Screening using Immunochemical Faecal Occult Blood Testing (iFOBT) in Urban-Poor Communities in Cheras, Malaysia: A Cross-Sectional Study
Publication Year: 2025 Source: Malays J Med Sci PMID: 40417191
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers globally, with the immunochemical faecal occult blood test (iFOBT) frequently used for population level screening. This study evaluated CRC screening uptake among urban-poor individuals aged 40-65, assessed their knowledge of CRC risk factors and symptoms before and after an …
Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus
Publication Year: 2025 Source: Open Med (Wars) PMID: 40417313 DOI: 10.1515/med-2025-1189
OBJECTIVE: We explored the causal relationship between pancreatitis and various autoimmune diseases using bidirectional Mendelian randomization (MR). METHODS: We collected genome-wide association study summary data for four pancreatitis types and five autoimmune diseases to conduct our bidirectional MR analysis. The primary analysis was performed using the inverse variance weighted (IVW) …
Impact of a 10-week multimodal stress management and lifestyle modification program on stress response and immune function in Crohn's disease: a mixed-methods approach using the Trier Social Stress Test
Publication Year: 2025 Source: Brain Behav Immun Health PMID: 40417396
One of the major factors for deterioration and relapse in inflammatory bowel diseases is chronic (psychological) stress. Aim of the present study was to compare the reaction of N = 33 patients with Crohn's disease that either participated in a multimodal stress management and lifestyle modification program (n = 19) …
Spatial immune profiling of Crohn's disease fistula carcinomas-defining a distinct cancer subtype
Publication Year: 2025 Source: J Crohns Colitis PMID: 40417996
BACKGROUND AND AIMS: Fistula formation is a common and debilitating complication in Crohn's disease (CD). CD-associated fistula carcinomas (Fi-Cas), though rare, pose diagnostic and prognostic challenges. This study aims to identify disease-defining immune cell subsets in CD-associated Fi-Cas. METHODS: The study included tissue samples from 10 CD patients with Fi-Cas, …
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