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Plasma inflammation-related proteins associated with anxiety and depression disorders in IBD patients
Publication Year: 2025 Source: Sci Rep PMID: 40419679 DOI: 10.1038/s41598-025-03543-1
Up to 25-35% of patients with inflammatory bowel disease (IBD) suffer from anxiety or depression. Mood disorders are correlated with activated inflammatory response. However, changes of inflammation-related proteins in IBD patients with anxiety or depression disorders are still unclear. We aimed to depict the plasma proteomics characteristics of IBD patients …
Time to classify: a narrative and scoping review of the old and the new classifications of perianal Crohn's disease
Publication Year: 2025 Source: Tech Coloproctol PMID: 40419817
Perianal Crohn's disease (pCD) is a complex manifestation of Crohn's disease. Classifying this patient cohort for both clinical purposes and for inclusion into research trials is challenging but crucial in order to improve outcomes. This review provides an overview of historical classifications of both fistulising and non-fistulising pCD, including the …
Efficacy of polyphenols in adjuvant treating ulcerative colitis: A meta-analysis of randomized controlled trials
Publication Year: 2025 Source: Medicine (Baltimore) PMID: 40419878
BACKGROUND: The effectiveness and safety of polyphenols in treating ulcerative colitis remain controversial. This study aimed to evaluate the efficacy and safety of polyphenols in the treatment of ulcerative colitis. METHODS: This study followed the preferred reporting items for systematic reviews and meta-analyses 2020 guidelines. A systematic search was conducted …
Intestinal organoids in inflammatory bowel disease: advances, applications, and future directions
Publication Year: 2025 Source: Front Cell Dev Biol PMID: 40421006 DOI: 10.3389/fcell.2025.1517121
Inflammatory bowel disease (IBD), characterized by chronic gastrointestinal inflammation, is a significant global health challenge. Traditional models often fail to accurately reflect human pathophysiology, leading to suboptimal treatments. This review provides an overview of recent advancements in intestinal organoid technology and its role in IBD research. Organoids, derived from patient-specific …
Exploring shared pathogenic mechanisms and biomarkers in hepatic fibrosis and inflammatory bowel disease through bioinformatics and machine learning
Publication Year: 2025 Source: Front Immunol PMID: 40421012 DOI: 10.3389/fimmu.2025.1533246
BACKGROUND: The coexistence of hepatic fibrosis (HF) and inflammatory bowel disease (IBD) represents a significant clinical concern due to their poorly characterized shared pathogenic mechanisms. Current limitations in identifying common biomarkers for comorbid cases impede early dual diagnosis and therapeutic interventions. METHODS: Differentially expressed genes (DEGs) were screened, followed by …
Efficacy and safety of dual-targeted therapy for refractory inflammatory bowel disease: a retrospective case series from three tertiary general hospitals in China
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40421289 DOI: 10.3389/fmed.2025.1566828
AIM: Dual-targeted therapy (DTT) may offer a promising approach for treating refractory inflammatory bowel disease (IBD). The aim of this case series was to evaluate the safety and clinical response of DTT in clinical practice. METHODS: We retrospectively analyzed data from refractory inflammatory bowel disease (IBD) patients receiving dual-target therapy …
Urgent Colectomies for Cancer: Evaluating the Role of Specialized Colorectal Surgeons
Publication Year: 2025 Source: Cureus PMID: 40421349
Background Urgent colectomies constitute a significant portion of acute care surgery (ACS). While general surgeons (GS) typically perform colonic resections, more complex cases, particularly those involving colorectal cancer (CRC) and inflammatory bowel disease, may demand a higher level of expertise. This study examines the outcomes of CRC-related urgent colectomies with …
Obinutuzumab-Induced Inflammatory Bowel Disease-Like Colitis
Publication Year: 2025 Source: Case Rep Oncol PMID: 40421460 DOI: 10.1159/000545677
INTRODUCTION: Obinutuzumab, an anti-CD20 antibody, is widely used in the treatment of B-cell lymphomas. While diarrhea is a known side effect, obinutuzumab-induced inflammatory bowel disease (IBD)-like conditions are rarely reported. Here, we present a case of obinutuzumab-induced pancolitis. CASE PRESENTATION: A 69-year-old male with stage IV follicular lymphoma, treated with …
The fate of thiopurine metabolites after switching to low-dose thiopurine with allopurinol or thioguanine in IBD patients: A retrospective analysis
Publication Year: 2025 Source: Br J Clin Pharmacol PMID: 40421668 DOI: 10.1002/bcp.70112
AIMS: Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6-MMPR production and (sub)therapeutic 6-TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low-dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD patients with shunting metabolism. METHODS: …
Phenotypic Differences and Clinical Outcomes of South Asian Children With IBD: A Singapore-Malaysia Study From the Asian PIBD Registry Network
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40421670 DOI: 10.1111/jgh.17020
BACKGROUND AND AIM: Existing literature largely contrasts pediatric inflammatory bowel disease (PIBD) phenotypic differences and outcomes of South Asians (SAs) with Caucasians. No published comparative data exist between SAs and non-SAs within Asia-Pacific. We aim to validate these comparisons within Asia-Pacific, comparing SAs ("Indian," "Bangladeshi," "Nepali," "Pakistani," "Sri Lankan (Sinhalese/Tamil)," …
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