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The role of gut leakage and immune cell miss-homing on gut dysbiosis-induced lung inflammation in a DSS mice model
Publication Year: 2025 Source: PLoS One PMID: 40435188 DOI: 10.1371/journal.pone.0324230
BACKGROUND: Inflammatory Bowel Disease (IBD), encompassing Crohn's disease and ulcerative colitis, affects millions globally, with extraintestinal manifestations (EIMs) occurring in 25-40% of patients. Among these, respiratory complications are of particular concern, yet the immunologic and physiologic mechanisms underlying gut-lung interactions remain poorly understood. The gut-lung axis (GLA) describes bi-directional communication …
Long-term in vivo monitoring of transplanted mesenchymal stromal cells in colitis mice with magnetic particle imaging
Publication Year: 2025 Source: EBioMedicine PMID: 40435720 DOI: 10.1016/j.ebiom.2025.105775
BACKGROUND: The successful development of mesenchymal stromal cells (MSCs)-based therapeutic strategies in inflammatory bowel disease (IBD) hinges on the ability to assess the influence of the administration route, while also tracking the cells' in vivo location, distribution, and long-term viability. Moreover, understanding the biological fate of these cells-particularly their activation, …
Unlocking the healing power of Jinhua white tea fermented by Eurotium cristatum using the unique "flowering" technology: A promising ally against inflammatory bowel disease
Publication Year: 2025 Source: Food Res Int PMID: 40436588 DOI: 10.1016/j.foodres.2025.116555
White tea (WT) has been reported to confer various health benefits, but its role in inflammatory bowel disease (IBD) has not been fully investigated. Jinhua white tea (JWT), produced using the unique "flowering" technology by Eurotium cristatum, enhancing the flavor and quality of WT. Whether this new technology provides better …
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity
Publication Year: 2025 Source: Nat Commun PMID: 40436823
Tissue-resident macrophages (TRM) are critical for mammalian organismal development and homeostasis. Here we report that with-no-lysine 1 (WNK1) controls myeloid progenitor fate, with Csf1r(iCre)-mediated Wnk1 deletion in mice (WNK1-deficient mice) resulting in loss of TRMs and causing perinatal mortality. Mechanistically, absence of WNK1 or inhibition of WNK kinase activity disrupts …
Role and mechanism of gut microbiota-host interactions in the pathogenesis of Crohn's disease
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 40437310
BACKGROUND: Crohn's disease (CD) is a chronic, nonspecific inflammatory bowel disease with a poor prognosis. Despite its increasing incidence, curing CD remains challenging due to its complex etiology and unclear pathogenesis. METHODS: A comprehensive PubMed and Web of Science search was conducted using the keywords Crohn's disease, gut microbiota, dysbiosis, …
Dietary glucosamine supplement use and lower surgery risk in individuals with inflammatory bowel disease: a prospective Cohort Study
Publication Year: 2025 Source: Eur J Nutr PMID: 40437330 DOI: 10.1007/s00394-025-03705-x
PURPOSE: We aim to evaluate the association between the use of glucosamine, a widely used dietary supplement, and the risk of IBD-related surgery in a prospective cohort study. METHODS: We leveraged data from 6059 individuals with IBD from the UK Biobank. Habitual use, frequency of use, and the dose of …
Comparative efficacy of preventive vs. therapeutic resveratrol in modulating gut microbiota and alleviating inflammation in DSS-induced colitis
Publication Year: 2025 Source: BMC Immunol PMID: 40437375 DOI: 10.1186/s12865-025-00718-3
BACKGROUND: Inflammatory bowel disease (IBD) management remains challenging due to limited preventive strategies and the low bioavailability of therapeutic agents like resveratrol (RSV). While RSV exhibits anti-inflammatory properties, its preventive potential via gut microbiome modulation remains unexplored. METHODS: A murine colitis model was established using 2.5% DSS, with mice randomized …
Genetic and Microbial Analysis of Invasiveness for Escherichia coli Strains Associated With Inflammatory Bowel Disease
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 40437706 DOI: 10.1016/j.jcmgh.2024.101451
BACKGROUND & AIMS: The adherent-invasive Escherichia coli (AIEC) pathotype is implicated in inflammatory bowel disease (IBD) pathogenesis. AIEC strains are currently defined by phenotypic measurement of their pathogenicity, including invasion of epithelial cells. This broad definition, combined with the genetic diversity of AIEC across patients with IBD, has complicated the …
cGAS-STING dependent type I IFN protects against Leptospira interrogans renal colonization in mice
Publication Year: 2025 Source: bioRxiv PMID: 40501870
Leptospira interrogans is the major causative agent of leptospirosis. Humans, canines and livestock animals are susceptible to Leptospira species and can develop fulminant disease. Rodents serve as reservoir hosts in which the bacteria colonize the renal tubules and are excreted in the urine. The host immune response to Leptospira spp. …
TRIC-Based High-Throughput Screening Enables the Discovery of Small Molecule CD28 Binders
Publication Year: 2025 Source: bioRxiv PMID: 40501875 DOI: 10.1101/2025.05.27.656499
CD28 is a pivotal costimulatory receptor involved in T cell activation and immune regulation, positioning it as a key therapeutic target for inflammatory diseases, including inflammatory bowel disease (IBD). Despite its potential, small molecules targeting CD28 are still limited. To fill this gap, we developed a high-throughput screening (HTS) platform …
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