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Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation
Publication Year: 2025 Source: bioRxiv PMID: 40501986 DOI: 10.1101/2025.05.24.655923
Intestinal epithelial damage and impaired repair are hallmarks of ulcerative colitis (UC), even after inflammation resolves. Intestinal stem cells (ISCs) can retain stable epigenetic changes after inflammation, highlighting the potential for long-lived epithelial memory in the gut. Inflammatory injury in barrier tissues induces epigenetic memory in epithelial stem cells, and …
A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis
Publication Year: 2025 Source: bioRxiv PMID: 40502184 DOI: 10.1101/2025.05.31.657160
Colitis-associated cancer (CAC) arises from a complex interplay between host and environmental factors, including the gut microbiome. Since ulcerative colitis (UC), a significant risk factor for CAC, is rising in prevalence worldwide, an integrative approach is essential to identify potential triggers linking inflammation to cancer. In the present study, we …
Visnagin treatment attenuates DSS-induced colitis by regulating inflammation, oxidative, stress, and mucosal damage
Publication Year: 2025 Source: Front Vet Sci PMID: 40502390
Ulcerative colitis (UC), is a chronic inflammatory bowel disease characterized by recurrent episodes of inflammation and ulceration of the colonic mucosa. This study aimed to explore the therapeutic potential effects of visnagin (VIS), a natural furanochromone using a murine model, focusing on tight junction protein expression, oxidative stress, apoptosis and …
Beyond the Bowel: Novel Comorbidity Patterns in Inflammatory Bowel Disease from the All of Us Research Program
Publication Year: 2025 Source: medRxiv PMID: 40502561 DOI: 10.1101/2025.06.01.25328740
BACKGROUND: Inflammatory bowel disease (IBD) manifests systemically, yet most comorbidity studies rely on predominantly European populations. The All of Us Research Program enables investigation across demographically diverse groups. METHODS: We matched 5,094 IBD patients 1:4 with controls by age, gender, and race, analyzing comorbidities using logistic regression with Mantel-Haenszel adjustment. …
SPC: a SPectral Component approach to address recent population structure in genomic analysis
Publication Year: 2025 Source: medRxiv PMID: 40502608 DOI: 10.1101/2025.06.04.25328990
Population structure is a well-known confounder in statistical genetics, particularly in genome-wide association studies (GWAS), where it can lead to inflated test statistics and spurious associations. Traditional methods, such as principal components (PCs), commonly used to adjust for population structure, are limited in capturing fine-scale, non-linear patterns that arise from …
Milk-derived exosomes exert anti-inflammatory activity in lipopolysaccharide-induced RAW264.7 cells by modulating the TLR4/NF-κB and PI3K/AKT signaling pathways
Publication Year: 2025 Source: Exp Ther Med PMID: 40502622
Inflammation is a protective response that occurs when the body is injured and is a primary pathological process that occurs in certain diseases, such as inflammatory bowel diseases, osteoarthritis and acute lung injury. Milk-derived exosomes (M-Exos) contain various physiologically active substances related to immunity. These substances can act on cells …
Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure
Publication Year: 2025 Source: Res Sq PMID: 40502773 DOI: 10.21203/rs.3.rs-6557500/v1
Unresolved tissue damage is a common feature of Inflammatory Bowel Disease (IBD) that facilitates disease progression. Here, we showed that high animal fat diets (HFD), an environmental risk factor associated with IBD pathogenesis, suppress intestinal macrophage production of critical tissue repair responses after damage. This includes reduced IL-23 production, which …
Terminal Ileal Endometriosis Masquerading as Crohn's Disease: A Rare Cause of Small Bowel Obstruction and Perforation in a Middle-Aged Woman
Publication Year: 2025 Source: Eur J Case Rep Intern Med PMID: 40502945
Endometriosis is a chronic inflammatory condition affecting 5-10% of women of reproductive age, most commonly involving pelvic organs. Gastrointestinal endometriosis, particularly at the terminal ileum, is rare and can clinically mimic other conditions such as Crohn's disease, posing significant diagnostic challenges. We report the case of a 45-year-old woman with …
Statins and the Risk of Colorectal Cancer in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Gastroenterology Res PMID: 40503187 DOI: 10.14740/gr2028
BACKGROUND: Statins are reported to reduce colorectal cancer (CRC) risk in the general population, but their effect on individuals with inflammatory bowel disease (IBD) remains uncertain. We aimed to evaluate the relationship between statin use and CRC risk in patients with IBD. METHODS: A comprehensive review of the literature was …
Evaluating the Impact of Co-Existent Inflammatory Bowel Disease on Hospital-Based Outcomes Among Patients With Acute Pancreatitis: An Analysis of the 2020 National Inpatient Sample Database
Publication Year: 2025 Source: Gastroenterology Res PMID: 40503190 DOI: 10.14740/gr2024
BACKGROUND: Inflammatory bowel disease (IBD) has been associated with increased risk of developing pancreatitis. We analyzed data from the National Inpatient Sample (NIS) with the aim of evaluating the outcomes of acute pancreatitis (AP) in patients with co-existent Crohn's disease (CD) or ulcerative colitis (UC). METHODS: This was a cross-sectional …
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