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Curcumin-QingDai Combination as Treatment for Crohn's Disease: A Case Report
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 40503450
INTRODUCTION: Curcumin and QingDai (QD, indigo) are two herbal extracts used in traditional medicine. A combination of curcumin with QD (CurQD) was reported to be effective in ulcerative colitis, but its effectiveness in Crohn's disease (CD) is unknown. We report on the use of CurQD for the treatment of CD. …
Fecal gut microbiota and amino acids as noninvasive diagnostic biomarkers of Pediatric inflammatory bowel disease
Publication Year: 2025 Source: Gut Microbes PMID: 40503566 DOI: 10.1080/19490976.2025.2517828
BACKGROUND AND AIMS: Fecal calprotectin (FCP) has limited specificity as diagnostic biomarker of pediatric inflammatory bowel disease (IBD), leading to unnecessary invasive endoscopies. This study aimed to develop and validate a fecal microbiota and amino acid (AA)-based diagnostic model. METHODS: Fecal samples from a discovery cohort (de novo IBD and …
Enhancing β-carotene bioavailability and protective effects for dextran sodium sulfate-induced colitis with sesame protein hydrolysate nanoparticles
Publication Year: 2025 Source: J Sci Food Agric PMID: 40503639 DOI: 10.1002/jsfa.14438
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic condition marked by recurring intestinal inflammation, leading to symptoms such as fatigue, diarrhea, and weight loss. Current treatments are limited, highlighting the need for new therapeutic strategies. beta-Carotene (BC), a natural antioxidant, has potential in managing colitis, but its low bioavailability limits …
Mechanistic insights into PFOS-induced inflammatory bowel disease: a network toxicology and molecular docking study
Publication Year: 2025 Source: Int J Surg PMID: 40503787 DOI: 10.1097/JS9.0000000000002638
OBJECTIVE: Perfluorooctanesulfonic acid (PFOS), a persistent environmental pollutant, is implicated in immune dysregulation. Rising inflammatory bowel disease (IBD) incidence parallels environmental contamination, yet PFOS's role in gut inflammation remains unclear. Its immunotoxicity may disrupt intestinal homeostasis via barrier dysfunction or cytokine imbalance, but molecular targets and pathways linking PFOS to …
Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice
Publication Year: 2025 Source: J Crohns Colitis PMID: 40503970 DOI: 10.1093/ecco-jcc/jjaf096
BACKGROUND AND AIMS: Inhibiting gamma-secretase mediated Notch signaling has been explored as a potential treatment for Alzheimer's disease and cancer. However, clinical trials have revealed that this approach can lead to side effects, such as gut inflammation. Notch signaling has been shown to be a key mediator of intestinal epithelial …
Real-time optical diagnosis of dysplasia with endocytoscopy in inflammatory bowel disease
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40503971
A 60-year-old male with ileocolic Crohn's disease diagnosed 36 years earlier (Montreal Classification: A2, L3, B1) underwent a surveillance colonoscopy. The examination revealed an 11 mm flat lesion in the transverse colon, presenting as a reddish plaque with indistinct borders under white light. Narrow band imaging (NBI) showed a regular …
Ischemic bowel disease characterized by colorectal mucosal necrosis induced by cardiac arrest
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40503973
The patient was a 60-year-old male. He developed impaired consciousness after drinking alcohol more than 20 days ago and was found 12 hours later to have an altered level of consciousness with vomiting. The vomit was brown in color. Cardiopulmonary resuscitation (CPR) was performed immediately after calling the emergency number …
Post-traumatic ileal stenosis: a rare entity not to be confused with Crohn's disease
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40503976
A 57-year-old woman with a history of polytrauma due to a car accident in March 2023 presented to de Emergency Room one month after this episode with subocclusive symptoms. CT scan revealed a 10cm proximal ileum segment as the reason of the subocclusion. This segment presented wall thickening, vascular engorgement, …
Interobserver variability of endoscopic scores and their subsections in Crohn's disease: a single-center prospective study
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40503977 DOI: 10.17235/reed.2025.10923/2024
BACKGROUND AND AIMS: Accurate endoscopic assessment in Crohn's disease (CD) is crucial, influencing treatment decisions and prognosis. However, endoscopic scores are complex and not easily applicable in routine practice. This study aimed to assess interobserver reproducibility of CDEIS, SES-CD and their subsections, in inflammatory bowel disease (IBD) experts and non-experts, …
Lovastatin alleviates DSS-induced colitis by modulating macrophage polarization via the PPARγ-NF-κB pathway
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40505233 DOI: 10.1016/j.intimp.2025.115068
Lovastatin, a pleiotropic cholesterol-lowering statin, possesses anti-inflammatory and immunomodulatory properties, yet its role in inflammatory bowel disease (IBD) remains unclear. This study investigates the anti-inflammatory effects of lovastatin in a dextran sulfate sodium (DSS)-induced colitis mouse model. We hypothesized that lovastatin alleviates colitis by modulating macrophage polarization via the PPARgamma-NF-kappaB …
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