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Apixaban Versus Enoxaparin for Venous Thromboembolism Prophylaxis in Colorectal Surgery
Publication Year: 2025 Source: J Surg Res PMID: 40505290
INTRODUCTION: Guidelines recommend postoperative venous thromboembolism (VTE) prophylaxis in colorectal cancer patients, as well as others at high risk of VTE. However, compliance, especially with injectable prophylaxis strategies remains challenging for patients and providers. Here, we evaluate the efficacy of apixaban versus enoxaparin in patients undergoing colorectal surgery (CRS) for …
Development and validation of a novel Endoscopic ulcer Activity Score for Evaluation of Crohn's Disease (EASE-CD) using data from two randomised controlled trials
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 40505666
BACKGROUND: Endoscopy is essential for measuring luminal disease activity in Crohn's disease. Existing indices for evaluating endoscopic Crohn's disease activity are only modestly correlated with clinical disease activity, contain items with ambiguous definitions and poor interobserver reliability, and do not have validated thresholds for defining clinically relevant changes. To address …
A new endoscopic paradigm: evaluating the EASE-CD score for Crohn's disease
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 40505667 DOI: 10.1016/S2468-1253(25)00127-X
No Abstract
Regulatory TCRαβ(+) Double Negative T Cells Suppress γδ T Cells and Alleviate Colitis
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 40505772
BACKGROUND AND AIMS: Inflammatory bowel disease arises from dysregulated immune activations triggered by a myriad of factors. The maintenance of immune tolerance within the intestinal milieu and the suppression of inflammatory responses remain the most efficacious strategies for alleviating enteritis. Regulatory TCRalphabeta(+) double-negative T (DNT) cells play pivotal roles in …
Janus kinase (JAK) inhibitor-induced acne in inflammatory bowel disease - an international, multicenter, retrospective cohort study
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40505791 DOI: 10.1016/j.cgh.2025.04.031
No Abstract
Innate immunity of the gut epithelium: Blowing in the WNT?
Publication Year: 2025 Source: Mucosal Immunol PMID: 40505889
Intestinal epithelial cells need to be able to launch a quick and adequate immune response against pathogens, while tolerating commensals. This delicate balance requires a tight control over the activation of the NFkappaB and Interferon pathways to prevent chronic inflammation. Simultaneously, intestinal stem cell maintenance and differentiation are strictly regulated …
Treatment targeting pediatric inflammatory bowel disease-associated anemia: experience from a single tertiary center
Publication Year: 2025 Source: Clin Exp Pediatr PMID: 40506048 DOI: 10.3345/cep.2025.00640
BACKGROUND: Iron deficiency (ID) and iron deficiency anemia (IDA) are common complications of pediatric inflammatory bowel disease (IBD). Owing to questions regarding optimal iron formulation, dosage, route of administration, and safety, these complications are frequently overlooked and undertreated, negatively impacting patient development and quality of life. PURPOSE: To assess the …
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight
Publication Year: 2025 Source: Behav Brain Funct PMID: 40506791 DOI: 10.1186/s12993-025-00283-0
BACKGROUND: In addition to classical gastrointestinal symptoms, patients with inflammatory bowel disease (IBD) often exhibit neurological manifestations, such as mood disorders and cognitive dysfunctions, which are frequently overlooked. However, the potential pathogenesis of IBD-related encephalopathy remains unclear, and few studies have explored the influence of interactions between the gut microbiota …
Diagnostic Methods and Biomarkers in Inflammatory Bowel Disease
Publication Year: 2025 Source: Diagnostics (Basel) PMID: 40506875 DOI: 10.3390/diagnostics15111303
Inflammatory bowel disease (IBD) refers to a chronic inflammatory condition involving the GI tract that includes Crohn's disease (CD) and ulcerative colitis (UC). These conditions are believed to arise in genetically predisposed individuals who develop an exaggerated immune response to the intestinal microbiota. A timely and accurate diagnosis of IBD …
The Association Between Fast Food Consumption and Inflammatory Bowel Disease: A Case-Control Study and Meta-Analysis
Publication Year: 2025 Source: Nutrients PMID: 40507107 DOI: 10.3390/nu17111838
Background: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic conditions influenced by various factors, including diet. This study examined the association between fast food consumption and IBD risk through a case-control study and a meta-analysis of epidemiological evidence. Methods: We analyzed data from a …
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