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Dietary Interventions and Oral Nutritional Supplementation in Inflammatory Bowel Disease: Current Evidence and Future Directions
Publication Year: 2025 Source: Nutrients PMID: 40507145 DOI: 10.3390/nu17111879
BACKGROUND: Nutritional management has become an integral part of Inflammatory Bowel Disease (IBD) care, with growing evidence supporting specific dietary interventions alongside pharmacologic therapy. However, clinical guidance remains fragmented due to heterogeneous study designs and variable endpoints. OBJECTIVES: This review critically examines the current evidence on dietary strategies and oral …
JAK Inhibitors and Risk of Cancer in IBD Patients
Publication Year: 2025 Source: Cancers (Basel) PMID: 40507276 DOI: 10.3390/cancers17111795
Janus kinase inhibitors, including tofacitinib, filgotinib, and upadacitinib, have emerged as effective therapeutic options for the management of inflammatory bowel diseases (IBDs). By targeting the JAK-STAT signaling pathway, these agents modulate immune responses and reduce inflammation. However, concerns regarding the potential risk of malignancy associated with their use have gained …
Multicenter Evaluation of the First Validated German-Language Fatigue Questionnaire for Patients with Chronic Inflammatory Bowel Diseases
Publication Year: 2025 Source: J Clin Med PMID: 40507380 DOI: 10.3390/jcm14113618
Background: Patients with inflammatory bowel disease (IBD) often suffer from extra-intestinal manifestations in addition to intestinal symptoms. One of these is fatigue. Fatigue is described as persistent tiredness with episodes of sudden energy loss, which cannot be relieved by rest or sleep and has a huge impact on quality of …
A Review of the Influence of Prebiotics, Probiotics, Synbiotics, and Postbiotics on the Human Gut Microbiome and Intestinal Integrity
Publication Year: 2025 Source: J Clin Med PMID: 40507435
OBJECTIVE: This review aims to comprehensively evaluate the current evidence on the role of prebiotics, probiotics, synbiotics, and postbiotics-collectively referred to as "biotics"-in modulating the human gut microbiota and enhancing intestinal epithelial integrity. FINDINGS: Biotics exert their beneficial effects through several mechanisms, including by promoting the growth of beneficial microbes, …
Diagnosing Ulcerative Colitis: Should We Go Beyond the Surface?
Publication Year: 2025 Source: J Clin Med PMID: 40507452
Ulcerative colitis is a chronic inflammatory bowel disease characterized by continuous mucosal inflammation of the large bowel. However, by conducting a literature search, it emerges that, although being considered a primary mucosal disorder in a subset of patients, the inflammatory process may extend beyond the mucosal surface. For this reason, …
Clinical and Genetic Characteristics of Pediatric Patients with Inflammatory Bowel Disease Transitioning to Adult Medicine: A Single-Center Ten-Year Experience
Publication Year: 2025 Source: J Clin Med PMID: 40507500 DOI: 10.3390/jcm14113741
Background/Objectives: Inflammatory bowel diseases (IBDs) comprise a group of chronic idiopathic disorders, including ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis (IC). Complex genetic factors, in addition to environmental triggers, have been shown to play a fundamental role in the pathogenesis of IBD, contributing to disease susceptibility. The transition …
Adherence to Exercise Training Within a Multimodal Prehabilitation Program: An Exploratory Study of Influencing Factors
Publication Year: 2025 Source: J Clin Med PMID: 40507576 DOI: 10.3390/jcm14113813
Background/Objectives: The real impact of prehabilitation in the healthcare setting is controversial due to the efficacy-effectiveness gap. The effectiveness of prehabilitation in real-world scenarios has been associated with program attrition and adherence. This study aimed to identify factors influencing adherence to a multimodal prehabilitation program for patients undergoing major surgery. …
Assessing Highly Processed Food Consumption in Patients with Inflammatory Bowel Disease: Application of the German Screening Questionnaire (sQ-HPF)
Publication Year: 2025 Source: J Clin Med PMID: 40507581 DOI: 10.3390/jcm14113819
Background/Objectives: The consumption of highly processed foods (HPFs) is increasing on a global scale, and these foods have been associated with non-communicable diseases (NCDs). In particular, the consumption of HPFs has been associated with the intensification of inflammatory responses, with these foods being implicated in the exacerbation of chronic inflammatory …
Changes in Medical Management of Inflammatory Bowel Disease and Reducing Surgical Risk: Investigating Causality Through the Bradford-Hill Criteria
Publication Year: 2025 Source: J Clin Med PMID: 40507591 DOI: 10.3390/jcm14113824
Background: Inflammatory bowel diseases (IBDs) are chronic progressive conditions, and their management has evolved over time, not only in the number of available medications but also in therapeutic strategies, resulting in a paradigm shift from treat-on-flare to treat-to-target, with the ultimate goal of modifying disease course. Several studies have shown …
Resilience and Self-Care in Patients with Inflammatory Bowel Disease: A Multicentre Cross-Sectional Study in Outpatient Settings
Publication Year: 2025 Source: J Clin Med PMID: 40507629 DOI: 10.3390/jcm14113868
Background/Objectives: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), significantly affects patients' quality of life. Resilience and self-care are vital for disease management, yet their relationship with IBD remains underexplored. This study investigates how self-care behaviours influence resilience in patients with IBD, taking into account sociodemographic …
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