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Designing a Unique Medical Student Workshop to Provide Early Exposure to Careers in Gastroenterology and Hepatology
Publication Year: 2025 Source: Cureus PMID: 40519417 DOI: 10.7759/cureus.84135
Background Medical students have limited knowledge of the subspecialties and procedural components within Gastroenterology (GI)/Hepatology (Hep). We crafted an interactive session to provide medical students with a broader understanding of the career paths in GI/Hep through perspectives from faculty and simulations. Methodology We conceptualized and organized the workshop in March …
Opioid Withdrawal Misdiagnosed as a Crohn's Flare
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 40519994
INTRODUCTION: There is an increased incidence of opioid use disorder (OUD) originating from prescription misuse. Diagnosing OUD remains challenging, particularly in patients with multiple medical comorbidities where other potential etiologies may cause overlapping symptoms. CASE PRESENTATION: This report highlights a 28-year-old male with Crohn's disease (CD) with recurrent hospitalizations of …
ITLN1 exacerbates Crohn's colitis by driving ZBP1-dependent PANoptosis in intestinal epithelial cells through antagonizing TRIM8-mediated CAPN2 ubiquitination
Publication Year: 2025 Source: Int J Biol Sci PMID: 40520022
Background: This study aimed to investigate the mechanisms by which PANoptosis of intestinal epithelial cells (IECs) promotes Crohn's disease (CD) progression. Methods: Single-cell RNA sequencing (scRNA-seq) was performed on inflamed and uninflamed colon tissues from patients with CD. The biological functions of intelectin-1 (ITLN1) in inflammation and PANoptosis were verified …
Comparing microsatellites and single nucleotide polymorphisms to evaluate genetic structure and diversity in wolverines (Gulo gulo) across Alaska and western Canada
Publication Year: 2025 Source: J Mammal PMID: 40520355 DOI: 10.1093/jmammal/gyae151
The Wolverine (Gulo gulo) is a cold-adapted species of conservation interest because it is sensitive to human development, disturbance, exploitation, and climate warming. Wolverine populations have been studied across much of their distributional range to evaluate patterns of genetic diversity, genetic structure, and gene flow. Little population structure has been …
Role of medico-administrative database in the selection of the target population in colorectal cancer screening program
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40520451
BACKGROUND: Colorectal cancer (CRC) screening in average-risk populations requires filtering a target population based on medical information in population-based CRC screening programs (CRCSP). This study describes the level of consensus in medical exclusion practice and the role of the medico-administrative databases (MADB) in accurately targeting the eligible individuals for CRCSP …
The gut virome in association with the bacteriome in gastrointestinal diseases and beyond: roles, mechanisms, and clinical applications
Publication Year: 2025 Source: Precis Clin Med PMID: 40520768
The gut virome, an essential component of the intestinal microbiome, constitutes approximately 0.1% of the total microbial biomass but contains a far greater number of particles than bacteria, with phages making up 90%-95% of this virome. This review systematically examines the developmental patterns of the gut virome, focusing on factors …
The Autonomic Nervous System in Acupuncture for Gastrointestinal Dysmotility: From Anatomical Insights to Clinical Medicine
Publication Year: 2025 Source: Int J Med Sci PMID: 40520904
The expanding knowledge on the involvement of the autonomic nervous system in regulating digestive tract homeostasis is shedding new light on the therapeutic potential of acupuncture. This review aims to evaluate the effectiveness and autonomic nervous system associated mechanisms of acupuncture in gastrointestinal dysmotility in both laboratory and clinical settings, …
Chronic Intestinal Inflammation and Microbial Dysbiosis Are Associated With Female Reproductive Outcomes in a Mouse Model of Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40520922
BACKGROUND AND AIMS: The mechanism for increased infertility and adverse pregnancy outcomes in women with active inflammatory bowel disease is unknown. We aimed to create a murine model of chronic gut inflammation to study the pathogenesis of reproductive outcomes in inflammatory bowel disease. METHODS: Chronic intestinal inflammation was induced with …
Peptide GTSFTTTAER From Rapana venosa Alleviates TNBS-Induced Inflammatory Bowel Disease in a Zebrafish Model via Multi-Pathway Regulation
Publication Year: 2025 Source: Food Sci Nutr PMID: 40521083 DOI: 10.1002/fsn3.70427
Inflammatory bowel disease (IBD) is a refractory chronic intestinal disease caused by immune dysfunction, with an unknown pathogenesis. In this study, the peptide GTSFTTTAER was isolated from Rapana venosa for treatment of IBD for the first time. We examined its protective effects on a zebrafish model of 2,4,6-trinitrobenzene sulfonic acid …
Pathologic Rate of Cancer After Surgery for Dysplasia Detected on Chromoendoscopy for Inflammatory Bowel Disease
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40521124 DOI: 10.1093/crocol/otaf032
INTRODUCTION: The objective of the study was to investigate the characteristics of patients who underwent surgery for dysplasia detected during chromoendoscopy (CE) surveillance for inflammatory bowel disease (IBD) and the incidence of cancer in the surgical specimen. METHODS: A retrospective review of medical records of all patients with dysplasia on …
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